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1.
J Am Geriatr Soc ; 64(10): 1988-1995, 2016 10.
Article in English | MEDLINE | ID: mdl-27627675

ABSTRACT

OBJECTIVES: To measure short-term changes in physical and cognitive function and emotional well-being of older adults receiving intensive chemotherapy for acute myeloid leukemia (AML). DESIGN: Prospective observational study. SETTING: Single academic institution. PARTICIPANTS: Individuals aged 60 and older with newly diagnosed AML who received induction chemotherapy (N = 49, mean age 70 ± 6.2, 56% male). MEASUREMENTS: Geriatric assessment (GA) was performed during inpatient examination for AML and within 8 weeks after hospital discharge after induction chemotherapy. Measures were the Pepper Assessment Tool for Disability (activity of daily living, instrumental activity of daily living (IADL), mobility questions), Short Physical Performance Battery (SPPB), grip strength, Modified Mini-Mental State examination, Center for Epidemiologic Studies Depression Scale, and the Distress Thermometer. Changes in GA measures were assessed using paired t-tests. Analysis of variance models were used to evaluate relationships between GA variables and change in function over time. RESULTS: After chemotherapy, IADL dependence worsened (mean 1.4 baseline vs 2.1 follow-up, P < .001), as did mean SPPB scores (7.5 vs 5.9, P = .02 for total). Grip strength also declined (38.9 ± 7.7 vs 34.2 ± 10.3 kg, P < .001 for men; 24.5 ± 4.8 vs 21.8 ± 4.7 kg, P = .007 for women). No significant changes in cognitive function (mean 84.7 vs 85.1, P = .72) or depressive symptoms (14.0 vs. 11.3, P = .11) were detected, but symptoms of distress declined (5.0 vs 3.2, P < .001). Participants with depressive symptoms at baseline and follow-up had greater declines in SPPB scores those without at both time points. CONCLUSIONS: Short-term survivors of intensive chemotherapy for AML had clinically meaningful declines in physical function. These data support the importance of interventions to maintain physical function during and after chemotherapy. Depressive symptoms before and during chemotherapy may be linked to potentially modifiable physical function declines.


Subject(s)
Activities of Daily Living/psychology , Cognition/physiology , Depression , Induction Chemotherapy , Leukemia, Myeloid, Acute , Aged , Depression/diagnosis , Depression/etiology , Depression/prevention & control , Female , Geriatric Assessment/methods , Humans , Induction Chemotherapy/adverse effects , Induction Chemotherapy/methods , Induction Chemotherapy/psychology , Leukemia, Myeloid, Acute/diagnosis , Leukemia, Myeloid, Acute/drug therapy , Leukemia, Myeloid, Acute/physiopathology , Leukemia, Myeloid, Acute/psychology , Male , Mental Health , Middle Aged , Mobility Limitation , Patient Discharge , Physical Examination/methods , Prospective Studies , Survivors
2.
Support Care Cancer ; 22(12): 3235-42, 2014 Dec.
Article in English | MEDLINE | ID: mdl-25011520

ABSTRACT

PURPOSE: Improvement in survival of pediatric acute lymphoblastic leukemia (ALL) has increased the attention to quality of life (QoL) . QoL is impaired during maintenance treatment, but little is known about QoL during induction therapy. Identification of patients with poor QoL during induction will provide opportunities for early interventions, and may subsequently improve future QoL. This national multi-center study aimed to assess QoL and its determinants during ALL induction treatment. METHODS: Proxy reports of the Child Health Questionnaire (CHQ) and the PedsQL cancer version were collected. Child, treatment, and parental characteristics were analyzed as potential determinants in a multiple regression model. RESULTS: One hundred thirty parents of children participated (response rate 82 %), median child age was 5.7 years and 48 % were female. QoL, as measured with the CHQ, was significantly lower than the norm, the effect sizes were large, and the differences were clinically relevant. Physical QoL was more often affected than psychosocial QoL. Regression models could be constructed for 4/ 10 CHQ scales and 6/ 8 PedsQL cancer scales, accounting for 7 to 36 % of the variance in scores. Impaired QoL was most often associated with older children, girls, and time since diagnosis. Also, father respondents seem to have a lower QoL perception compared to mother respondents although this needs to be confirmed in future research. CONCLUSIONS: Specific counseling for subsets of patients with a higher risk of low QoL during the early phases of therapy is warranted.


Subject(s)
Child Care , Induction Chemotherapy , Parents/psychology , Precursor Cell Lymphoblastic Leukemia-Lymphoma , Quality of Life , Age of Onset , Child , Child Care/methods , Child Care/organization & administration , Child Care/psychology , Child, Preschool , Female , Humans , Induction Chemotherapy/methods , Induction Chemotherapy/psychology , Longitudinal Studies , Male , Needs Assessment , Neoadjuvant Therapy , Netherlands/epidemiology , Precursor Cell Lymphoblastic Leukemia-Lymphoma/epidemiology , Precursor Cell Lymphoblastic Leukemia-Lymphoma/psychology , Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy , Prospective Studies , Proxy , Risk Factors , Sex Factors , Surveys and Questionnaires
3.
J Clin Psychol Med Settings ; 20(1): 13-24, 2013 Mar.
Article in English | MEDLINE | ID: mdl-22739660

ABSTRACT

An acute leukemia diagnosis can be an extremely stressful experience for most patients. Posttraumatic growth (PTG) is positive psychological change experienced following a struggle with highly challenging life circumstances. The current study is the first longitudinal investigation of predictors of PTG and distress in adult acute leukemia patients undergoing induction chemotherapy. Findings suggest that these patients report PTG, and levels of PTG appear to increase over the weeks following leukemia diagnosis and induction chemotherapy. Variables associated with higher total PTG scores over time included greater number of days from baseline, younger age, and greater challenge to core beliefs. Variables associated with higher distress included greater number of days from baseline, greater perceived cancer threat, higher symptom severity, and lower spiritual well-being. Results underscore the critical role that examination of one's core beliefs may play in the development of PTG over time.


Subject(s)
Induction Chemotherapy/psychology , Leukemia, Myeloid, Acute/drug therapy , Leukemia, Myeloid, Acute/psychology , Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy , Precursor Cell Lymphoblastic Leukemia-Lymphoma/psychology , Quality of Life/psychology , Resilience, Psychological , Stress Disorders, Post-Traumatic/diagnosis , Stress Disorders, Post-Traumatic/psychology , Academic Medical Centers , Acute Disease , Adaptation, Psychological , Adolescent , Adult , Aged , Aged, 80 and over , Consolidation Chemotherapy/psychology , Culture , Defense Mechanisms , Female , Humans , Longitudinal Studies , Male , Middle Aged , Mood Disorders/diagnosis , Mood Disorders/psychology , North Carolina , Patient Readmission , Personality Inventory/statistics & numerical data , Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis , Psychometrics , Sick Role , Young Adult
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