ABSTRACT
The research was performed in 55 male chinchilla rabbits. For the first time the effect of metabolic preparations "citoflavin" and "neoton" of the protein-lipid spectrum of blood was studied in experimental diffuse purulent peritonitis. The development of diffuse purulent peritonitis caused negative changes in blood lipid-transport system which resulted in a decreased blood protein level and high density lipoproteins (HDL) and growth of triglycerides. In the HDL phospholipid spectrum the pathological changes are characterized by an increased lisophosphotide content and compensatory growth of the level of poliglycerophosphatides. A comparative analysis has shown that both preparations possess unidirectional action which is more pronounced in "citoflavin" than in "neoton".
Subject(s)
Flavin Mononucleotide , Inosine Diphosphate , Laparotomy , Lipid Metabolism/drug effects , Niacinamide , Peritoneal Lavage , Peritonitis , Phosphocreatine , Succinates , Animals , Biological Transport/drug effects , Combined Modality Therapy , Drug Combinations , Drug Monitoring/methods , Flavin Mononucleotide/administration & dosage , Flavin Mononucleotide/pharmacokinetics , Infusions, Intravenous/methods , Inosine Diphosphate/administration & dosage , Inosine Diphosphate/pharmacokinetics , Male , Models, Animal , Niacinamide/administration & dosage , Niacinamide/pharmacokinetics , Peritonitis/metabolism , Peritonitis/physiopathology , Peritonitis/therapy , Phosphocreatine/administration & dosage , Phosphocreatine/pharmacokinetics , Protective Agents/administration & dosage , Protective Agents/pharmacokinetics , Rabbits , Research Report , Succinates/administration & dosage , Succinates/pharmacokinetics , Suppuration/metabolism , Suppuration/therapy , Time Factors , Treatment Outcome , Vitamins/administration & dosage , Vitamins/pharmacokineticsABSTRACT
Method of complex surgical treatment of inguinal hernia in children, basing on the early conduction of surgical correction of pathology, application of microsurgical technique of the operation conduction, using of pharmacologic defense of hematotesticular barrier and medicinal therapy of the man sexual gland ischemia, was elaborated and substantiated.
