ABSTRACT
Until very recently, intervertebral disc innervation was a subject of considerable debate. Nowadays, the introduction of inmunohistochemical techniques associated to specific antibodies and studies with retrograde tracers in nerves have allowed greater understanding of disc innervation in physiological and pathological conditions and also endings characteristics and their patterns of distribution in both situations. The existing controversies regarding structural basis of discogenic pain, have raised the interest of knowing the influence of innervation in back pain from discal origin and its characteristics. Today, we know that pathologic neoinnervation accompanying radial fissures is an important factor in the genesis of discogenic pain; within a complex mechanism in which other neurobiomechemical, inflammatory and biomechanical factors are involved.
Subject(s)
Back Pain/etiology , Intervertebral Disc/innervation , Adrenergic Fibers/physiology , Back Pain/physiopathology , Humans , Immunohistochemistry , Inflammation , Inflammation Mediators/physiology , Intervertebral Disc Displacement/embryology , Intervertebral Disc Displacement/etiology , Intervertebral Disc Displacement/physiopathology , Mechanoreceptors/physiology , Nerve Growth Factors/physiology , Nociceptors/physiology , Sensory Receptor Cells/physiologyABSTRACT
The AA. present a study on the relationship between the most common congenital malformation of the lumbosacral passage: the sacralization of L5 and lumbar disc hernia. The examination of 200 cases of lumbar disc hernia shows a sacralization incidence of 11.5%.
