ABSTRACT
BACKGROUND: Thyroid gland is a probable goal tissue for radiation-related injury. Occupational exposure to ionizing radiation leads to thyroid dysfunction and exposure to high dose may lead to thyroid carcinoma. OBJECTIVE: Evaluation of the role of Thyroid peroxidase antibody as a predictor for thyroid dysfunction among nurses and technicians in the radiology department in Mansoura Specialized Medical hospital (MSMH). SUBJECTS AND METHODS: Subjects were Nurses and technicians who are working in (MSMH) with persistent daily duty in the last 3 years and fulfilling the inclusion and exclusion criteria. All subjects included in the study were recruited in one month and divided into two groups; Group 1: 50 subjects who were working in radiology, coronary angiography and ERCP unit, Radiation -exposed group. Group 2: 33 subjects who were working in In-patient departments and in out- patient clinics and not exposed to any type of radiation. Non fasting blood sample was taken from all enrolled subjects for measurement of TSH and Anti-TPO. RESULTS: TPO was positively and significantly correlated to age, TSH, duration of radiology/ y (r=0.388, 0.364, 0.342respectively) p value <0.05. Roc curve was done to detect the sensitivity and specificity of TSH in relation to TPO that revealed the cutoff value of TSH > 1.69 with Sensitivity and Specificity. PPV, NPV and accuracy at cutoff >1.69 were 70.6%, 51.5%, 42.8%, 77.3% and 58%. CONCLUSION: Working personnel with positive anti TPO and their TSH levels are more than 1.69 associated with symptoms of hypothyroidism, a trial of treatment is mandatory to relieve symptoms.
Subject(s)
Autoantigens/blood , Health Personnel , Hospitals, Special , Iodide Peroxidase/blood , Iron-Binding Proteins/blood , Occupational Exposure/adverse effects , Radiation Injuries/blood , Thyroid Diseases/blood , Adult , Autoantibodies/blood , Autoantibodies/radiation effects , Autoantigens/radiation effects , Cross-Sectional Studies , Egypt/epidemiology , Female , Humans , Iodide Peroxidase/radiation effects , Iron-Binding Proteins/radiation effects , Male , Middle Aged , Predictive Value of Tests , Radiation Exposure/adverse effects , Radiation Injuries/diagnosis , Thyroid Diseases/epidemiology , Young AdultABSTRACT
Exposure to ionized radiation in childhood has been recognized as a risk factor for the development of thyroid cancer and possibly for other thyroid disorders. However, the effects of neonatal radiation exposure on thyroid morphology and functions have never been explored despite its potential importance. One-week-old male Wistar rats were subjected to cervical X-irradiation at 6 and 12 Gy. Animals were examined at the ages of 2, 8 and 18 weeks old. For comparison, 8-week-old rats were cervically X-irradiated at the same doses. Thyroid histology was examined by computer-assisted microscopy to measure areas of colloid and epithelium of thyroid follicles as well as epithelial heights. In rats that received cervical X-irradiation at 1 week old, the colloid size of thyroid follicles decreased at the age of 8 weeks old in a radiation-dose dependent manner. This morphological change was persistently found at 18 weeks old. There were no significant differences in serum total T3 or T4 levels among the groups. Serum TSH levels increased significantly in 8-week-old rats neonatally X-irradiated. Thyroglobulin (Tg) mRNA and protein expressions were significantly decreased in the neonatally-irradiated group while thyroid peroxidase mRNA express increased at 18 weeks old. None of these changes were observed in the rats X-irradiated at 8 weeks old. In conclusion, our results clearly demonstrated that neonatal rat thyroid was sensitive to ionized radiation, developing specific morphological changes characterized by smaller thyroid follicles along with changes in serum TSH levels and Tg expressions in the thyroid tissue.
Subject(s)
Iodide Peroxidase/radiation effects , Thyroglobulin/radiation effects , Thyroid Gland/radiation effects , Thyrotropin/radiation effects , Thyroxine/radiation effects , Triiodothyronine/radiation effects , X-Rays , Age Factors , Animals , Animals, Newborn , Blotting, Western , Dose-Response Relationship, Radiation , Iodide Peroxidase/genetics , Iodide Peroxidase/metabolism , Male , Neck , RNA, Messenger/metabolism , RNA, Messenger/radiation effects , Radiation Dosage , Rats , Rats, Wistar , Reverse Transcriptase Polymerase Chain Reaction , Thyroglobulin/genetics , Thyroglobulin/metabolism , Thyroid Gland/metabolism , Thyroid Gland/pathology , Thyrotropin/metabolism , Thyroxine/metabolism , Triiodothyronine/metabolismABSTRACT
The effects of external acute irradiation at dose 1.0 Gy on biologic, haematologic and metabolic changes in blood of alloxan-induced diabetic rats were studied. It was found that the deterioration of diabetic animals occurs in different terms after irradiation exposure, resulting in considerable body weight decrease, well-marked hyperglycemia, abrupt falling of leukocytic system parameters, intensification energetic processes of extant lymphocytes, imbalance of lipid metabolism and thyroid state, as well as significant inhibition of 5'-deiodinase activity in liver tissue.
