Subject(s)
Bronchography , Foreign-Body Reaction/chemically induced , Granuloma, Foreign-Body/chemically induced , Iodopyridones/adverse effects , Lung Diseases/chemically induced , Lung Diseases/diagnostic imaging , Propyliodone/adverse effects , Granuloma, Foreign-Body/pathology , Humans , Lung/pathology , Lung Diseases/pathologySubject(s)
Antibodies, Fungal/analysis , Asthma/chemically induced , Cladosporium/immunology , Contrast Media/adverse effects , Immunoglobulin E/analysis , Iodopyridones/adverse effects , Mitosporic Fungi/immunology , Propyliodone/adverse effects , Pulmonary Eosinophilia/chemically induced , Bronchography , Humans , Male , Middle Aged , Pulmonary Alveoli/diagnostic imagingABSTRACT
Thyroid function was studied in 27 subjects who underwent bronchography with propyliodone (18-70 ml, containing 30% of organic iodine). Sustained elevations of serum non-hormonal iodine were observed, indicating that significant amounts of propyliodone were absorbed from the bronchial tree and also that elimination may take several weeks. During the period of anaesthesia, there was an increase in thyroxine-binding globulin and all thyroid hormones which was transient and probably reflected vascular response to the anaesthetic. T4-T3 conversion was inhibited with a nadir of T3 and a peak of rT3 occurring on the 2nd day after propyliodone exposure. FT4 increased gradually during the 2 weeks after bronchography, but remained within the normal range. 6 out of the 27 patients developed pathologic T4 levels, 3 elevated T3 levels, and 2 an abnormal response to thyrotropin-releasing hormone; these changes might have been confused with hyperthyroidism. None of the patients developed clinical thyrotoxicosis; however, in patients with autonomous thyroid tissue, the same precautions should be taken with propyliodone as with other iodine-containing agents which are known to induce hyperthyroidism in this situation.
Subject(s)
Bronchography/adverse effects , Iodopyridones/adverse effects , Propyliodone/adverse effects , Thyroid Gland/physiology , Adult , Blood Proteins/metabolism , Female , Humans , Iodine/blood , Male , Middle Aged , Thyrotropin-Releasing Hormone , Thyroxine/blood , Thyroxine-Binding Proteins/metabolism , Time Factors , Triiodothyronine/blood , Triiodothyronine, Reverse/bloodABSTRACT
Severe reactions to oily propyliodone are rare. Side-effects are usually mild and self-limiting. Three cases are reported of early pulmonary reactions, the cause of which may be a chemical pneumonitis or possibly an allergic response to one of the components of the contrast medium. There was a good response to corticosteroid therapy in all three patients.
Subject(s)
Iodopyridones/adverse effects , Lung Diseases/chemically induced , Oils/adverse effects , Plant Oils , Propyliodone/adverse effects , Adult , Bronchography , Female , Humans , Lung Diseases/diagnostic imaging , Male , Peanut OilABSTRACT
Cerebral embolization of an aqueous solution of propyliodone (Dionosil) occurred during selective bronchographic studies following a fiberoptic bronchoscopic procedure with transbronchial biopsy in a patient undergoing investigation of a pulmonary lesion. The embolization resulted in a grand mal seizure and transient neurologic deficits. This potential complication has not been previously reported. We suggest that selective bronchographic studies be avoided when the transbronchial biopsy is associated with endobronchial bleeding.
