Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 32.265
Filter
1.
JMIR Aging ; 7: e53141, 2024 May 30.
Article in English | MEDLINE | ID: mdl-38825851

ABSTRACT

Background: During COVID-19 lockdowns, older adults' engagement in daily activities was severely affected, causing negative physical and mental health implications. Technology flourished as a means of performing daily activities in this complex situation; however, older adults often struggled to effectively use these opportunities. Despite the important role of older adults' social environments-including their families and health professionals-in influencing their technology use, research into their unique perspectives is lacking. Objective: This study aimed to explore the daily activity performance, health, and technology use experiences of healthy independent Israeli adults (aged ≥65 years) during COVID-19 from a 3-dimensional perspective: older adults, older adults' family members, and health professionals. Methods: Nine online focus groups, averaging 6-7 participants per group, were conducted with older adults, family members, and health professionals (N=59). Data were analyzed using thematic analysis and constant comparative methods. Results: The intertwining of daily activity performance and health emerged as a central theme, with differences between the groups. Older adults prioritized their self-fulfilling routines based on motivation and choice, especially in social-familial activities. In contrast, family members and health professionals focused on serious physical and mental health COVID-19-related consequences. A consensus among all three groups revealed the meaningful role of technology use during this period in bridging functional limitations. Participants delved into technology's transformative power, focusing on the need for technology to get engaged in daily activities. Conclusions: This study illustrates the profound interplay between daily activity performances, physical and mental health, and technology use, using a 3-dimensional approach. Its focus on technology's uses and benefits sheds light on what older adults need to increase their technology use. Interventions for improving digital activity performance can be tailored to meet older adults' needs and preferences by focusing on motivational and preference-related activities.


Subject(s)
Activities of Daily Living , COVID-19 , Focus Groups , Humans , COVID-19/psychology , COVID-19/epidemiology , Aged , Male , Female , Activities of Daily Living/psychology , Israel/epidemiology , Aged, 80 and over , Family/psychology , Health Personnel/psychology , Mental Health , Health Status
2.
J Med Virol ; 96(6): e29709, 2024 Jun.
Article in English | MEDLINE | ID: mdl-38828947

ABSTRACT

This study evaluated the epidemiological and clinical characteristics of human metapneumovirus (hMPV) infection among hospitalized patients with acute respiratory infections during 2015-2021 and assessed the impact of the coronavirus disease 2019 pandemic on hMPV infection. A single-center, retrospective cohort study was performed, including pediatric and adult patients with laboratory-confirmed hMPV. Of a total of 990 patients, 253 (25.6%), 105 (10.6%), 121 (12.2%), and 511 (51.6%) belonged to age groups 0-2, 3-17, 18-59, and ≥60 years, respectively. The highest percentage (23.0%) of patients were hospitalized during 2019 and the lowest (4.7%) during 2020. Patients < 18 years experienced high rates of comorbidities (immunodeficiencies: 14.4% and malignancies: 29.9%). Here, 37/39 (94.9%) of all bronchiolitis cases were diagnosed in patients < 2 years, whereas more patients in older age groups were diagnosed with pneumonia. A greater proportion of hMPV patients diagnosed with viral coinfection (mostly respiratory syncytial virus and adenovirus) were <18 years. The highest percentages of intensive care unit admissions were recorded among patients < 18 years. Our findings demonstrate that hMPV is an important cause of morbidity in young children and a possibly underestimated cause of morbidity among older adults.


Subject(s)
COVID-19 , Coinfection , Hospitalization , Metapneumovirus , Paramyxoviridae Infections , Humans , Retrospective Studies , Metapneumovirus/isolation & purification , Paramyxoviridae Infections/epidemiology , Paramyxoviridae Infections/virology , Israel/epidemiology , Middle Aged , Child , Male , Adult , Female , Infant , Adolescent , Child, Preschool , Hospitalization/statistics & numerical data , Young Adult , COVID-19/epidemiology , COVID-19/virology , Aged , Coinfection/epidemiology , Coinfection/virology , Infant, Newborn , Respiratory Tract Infections/epidemiology , Respiratory Tract Infections/virology , Comorbidity , Aged, 80 and over , SARS-CoV-2
3.
Psychol Aging ; 39(3): 324-336, 2024 May.
Article in English | MEDLINE | ID: mdl-38829343

ABSTRACT

Judging the perspective of others often requires ignoring one's own accessible knowledge. Aging increases reliance on the most available knowledge and may decrease the adjustment of this knowledge to adopt another perspective. Using a dominant language also decreases control demands, while using a nondominant language promotes deliberation. We examined whether aging and language dominance shape the way in which individuals judge someone else's interpretation of ambiguous messages. Russian-Hebrew bilinguals (N = 237, ages 19-80) read 20 ambiguous messages and judged how a recipient would interpret them. Half of the texts contained information that suggested that the message was sincere, and half of the texts contained information that implied that the message was sarcastic. This information was available only to the participant and should not have affected the recipient's interpretation. An egocentric bias emerged in both languages since participants could not ignore their own knowledge when judging the recipient's perspective. Aging was associated with a greater bias, but the results were similar in both languages. A second study included 60 younger (ages 18-39) and 62 older (ages 60-80) Israeli-born participants, who performed the same task as well as a flanker task (i.e., judging the direction of a central arrow flanked by congruent and incongruent distractors). Age interacted with the egocentric bias, but there was no correlation between the flanker effect and perspective judgment. Thus, decreased inhibition, as measured by the flanker task, cannot account for the egocentric bias. We suggest that the findings reflect difficulty in overriding highly accessible information, especially in older age. (PsycInfo Database Record (c) 2024 APA, all rights reserved).


Subject(s)
Aging , Judgment , Multilingualism , Humans , Aged , Adult , Middle Aged , Female , Male , Young Adult , Aged, 80 and over , Aging/psychology , Aging/physiology , Adolescent , Israel , Russia , Social Perception
4.
PeerJ ; 12: e17425, 2024.
Article in English | MEDLINE | ID: mdl-38832036

ABSTRACT

We report new data on non-indigenous invertebrates from the Mediterranean Sea (four ostracods and 20 molluscs), including five new records for the basin: the ostracods Neomonoceratina iniqua, Neomonoceratina aff. mediterranea, Neomonoceratina cf. entomon, Loxoconcha cf. gisellae (Arthropoda: Crustacea)-the first records of non-indigenous ostracods in the Mediterranean-and the bivalve Striarca aff. symmetrica (Mollusca). Additionally, we report for the first time Electroma vexillum from Israel, and Euthymella colzumensis, Joculator problematicus, Hemiliostraca clandestina, Pyrgulina nana, Pyrgulina microtuber, Turbonilla cangeyrani, Musculus aff. viridulus and Isognomon bicolor from Cyprus. We also report the second record of Fossarus sp. and of Cerithiopsis sp. cf. pulvis in the Mediterranean Sea, the first live collected specimens of Oscilla galilae from Cyprus and the northernmost record of Gari pallida in Israel (and the Mediterranean). Moreover, we report the earliest records of Rugalucina angela, Ervilia scaliola and Alveinus miliaceus in the Mediterranean Sea, backdating their first occurrence in the basin by 3, 5 and 7 years, respectively. We provide new data on the presence of Spondylus nicobaricus and Nudiscintilla aff. glabra in Israel. Finally, yet importantly, we use both morphological and molecular approaches to revise the systematics of the non-indigenous genus Isognomon in the Mediterranean Sea, showing that two species currently co-occur in the basin: the Caribbean I. bicolor, distributed in the central and eastern Mediterranean, and the Indo-Pacific I. aff. legumen, at present reported only from the eastern Mediterranean and whose identity requires a more in-depth taxonomic study. Our work shows the need of taxonomic expertise and investigation, the necessity to avoid the unfounded sense of confidence given by names in closed nomenclature when the NIS belong to taxa that have not enjoyed ample taxonomic work, and the necessity to continue collecting samples-rather than relying on visual censuses and bio-blitzes-to enable accurate detection of non-indigenous species.


Subject(s)
Bivalvia , Animals , Mediterranean Sea , Bivalvia/classification , Crustacea/classification , Mollusca/classification , Israel , Animal Distribution , Introduced Species
5.
J Am Assoc Nurse Pract ; 36(5): 262-269, 2024 May 01.
Article in English | MEDLINE | ID: mdl-38691658

ABSTRACT

BACKGROUND: There is an increasing demand for comprehensive geriatric care. Nurse practitioners (NPs), who undergo specialized training, are situated to provide such care. In Israel, the role of a geriatric nurse practitioner was introduced in the health care system 10 years ago. However, little is known about the rate of professional satisfaction and realization of full potential among these nurses. PURPOSE: The aims of this study are (1) to describe the geriatric NP workforce in Israel, (2) to measure the current geriatric scope of practice, and (3) to measure the geriatric NP satisfaction from their working environment. METHODOLOGY: For this cross-sectional study, a survey, comprising three sections relating to demographics, professional qualifications and scope of practice, and career satisfaction, was sent to 53 geriatric nurse practitioners in Israel who currently work as geriatric nurse practitioners. RESULTS: Forty-seven nurses participated in the survey. Almost 64% reported that they are satisfied with their position, and 72% reported that they are able to fulfill their full scope of practice. The mean score for scope of practice was 68.31 out of a possible score of 100. CONCLUSIONS: A number of qualifications were correlated with satisfaction at work, indicating that nurses tend to be more satisfied at work when they are able to fulfill their potential. IMPLICATIONS: Ensuring nurse practitioners' ability to realize their full potential should be a goal of the health care system. Interventions should be in place to encourage nurses to perform tasks related to their work, for which they are trained.


Subject(s)
Job Satisfaction , Nurse Practitioners , Humans , Israel , Nurse Practitioners/statistics & numerical data , Nurse Practitioners/psychology , Cross-Sectional Studies , Female , Surveys and Questionnaires , Adult , Male , Middle Aged , Scope of Practice , Geriatric Nursing/methods
6.
Am J Disaster Med ; 19(2): 175-178, 2024.
Article in English | MEDLINE | ID: mdl-38698516

ABSTRACT

On October 7, 2023, over 2,500 Hamas terrorists infiltrated Israel from Gaza and killed over 1,400 people and injured 2,800, resulting in the largest terrorist attack in Israel's history. Several models describe the principles of managing a mass casualty event. One of them is an Australian construct known as the six C's. While command, control, and coordination are familiar concepts, the six C's emphasize the importance of communication and community (consequences and community connection). We describe how two emergency departments in Israel-Assuta Ashdod and the Hadassah Medical Center-Ein Kerem-responded to this disaster in the context of the six C's.


Subject(s)
Disaster Planning , Mass Casualty Incidents , Terrorism , Humans , Israel , Disaster Planning/organization & administration , Emergency Service, Hospital/organization & administration , Emergency Medical Services/organization & administration
7.
PLoS One ; 19(5): e0302266, 2024.
Article in English | MEDLINE | ID: mdl-38701039

ABSTRACT

INTRODUCTION: Mothers faced an increased risk of adverse mental health outcomes during the COVID-19 pandemic compared to other populations. However, there is little data on the factors that placed mothers at increased risk of distress. AIMS: The present study explored a range of individual, familial, and environmental factors associated with psychological distress in mothers during the COVID-19 pandemic. METHOD: This repeated cross-sectional study was composed of a convenience sample of mothers who completed an online survey that included a demographic questionnaire, an emotion regulation questionnaire, and the Depression, Anxiety, and Stress scale. The survey was administered during the second and third lockdowns in Israel in 2020-2021. RESULTS: The study included 575 mothers (M age = 39). The findings of a hierarchical regression indicated that individual-level factors, composed of age and emotion regulation tendencies predicted psychological distress. The family-level factors of household income and number of children in the family also predicted distress. In terms of environmental-level factors, COVID-19-related media consumption and school status (open or closed) were also significant predictors of psychological distress. Importantly, the results showed that the most important predictors of psychological distress in mothers during the COVID-19 outbreak were school closures, household income, and the use of adaptive and maladaptive emotion regulation strategies. CONCLUSIONS: The findings highlight the intersection of individual, familial, and environmental factors in mothers' mental health during crises.


Subject(s)
COVID-19 , Mothers , Psychological Distress , Humans , COVID-19/epidemiology , COVID-19/psychology , Female , Adult , Mothers/psychology , Cross-Sectional Studies , Middle Aged , Surveys and Questionnaires , Stress, Psychological/epidemiology , Stress, Psychological/psychology , Israel/epidemiology , SARS-CoV-2/isolation & purification , Anxiety/epidemiology , Anxiety/psychology , Depression/epidemiology , Depression/psychology , Mental Health , Pandemics , Emotional Regulation
9.
Nat Commun ; 15(1): 3764, 2024 May 04.
Article in English | MEDLINE | ID: mdl-38704361

ABSTRACT

Crohn disease (CD) burden has increased with globalization/urbanization, and the rapid rise is attributed to environmental changes rather than genetic drift. The Study Of Urban and Rural CD Evolution (SOURCE, n = 380) has considered diet-omics domains simultaneously to detect complex interactions and identify potential beneficial and pathogenic factors linked with rural-urban transition and CD. We characterize exposures, diet, ileal transcriptomics, metabolomics, and microbiome in newly diagnosed CD patients and controls in rural and urban China and Israel. We show that time spent by rural residents in urban environments is linked with changes in gut microbial composition and metabolomics, which mirror those seen in CD. Ileal transcriptomics highlights personal metabolic and immune gene expression modules, that are directly linked to potential protective dietary exposures (coffee, manganese, vitamin D), fecal metabolites, and the microbiome. Bacteria-associated metabolites are primarily linked with host immune modules, whereas diet-linked metabolites are associated with host epithelial metabolic functions.


Subject(s)
Crohn Disease , Diet , Gastrointestinal Microbiome , Rural Population , Urban Population , Crohn Disease/microbiology , Crohn Disease/genetics , Humans , Male , Female , China/epidemiology , Adult , Israel/epidemiology , Metabolomics , Cohort Studies , Middle Aged , Feces/microbiology , Ileum/microbiology , Ileum/metabolism , Transcriptome , Young Adult
10.
Adv Life Course Res ; 60: 100614, 2024 Jun.
Article in English | MEDLINE | ID: mdl-38749369

ABSTRACT

Despite changes in women's status in recent decades in Arab-Palestinian society in Israel, marriage and motherhood still play a central role. Moreover, although the increase in the integration rates of young Arab-Palestinian women into the higher education system, as girls belonging to a minority group with traditional structures, they are expected to prioritize family and community expectations over personal aspirations. This study focuses on art projects of female Arab-Palestinian college students in Israel, which serve as a prism for detecting cultural perceptions of pathways to entering adulthood among this population today. These topics are central themes in the projects in question. Working on these projects forced the students to profoundly contemplate their life stage - being engaged or newly married and young mothers. The aim of the study was to decode the artworks in order to explore the students' feelings and thoughts on a topic rarely considered through the eyes of the young women themselves. The study provides a nuanced examination of the social processes that young educated Arab-Palestinian women experience in the current family structure. By analysing the projects using visual tools from semiotics and art history, along with verbal texts provided by the students, we assert that these projects serve as a crucial avenue for students' self-expression regarding topics seldom addressed. Even though the projects cannot be understood as critical of traditional gender expectations, we did find some interesting voices of unease regarding them. The move from their parents' home to their new one is widely described as difficult, where sadness and concern about the future are highly noticeable. In addition to accepting the stages of marriage and motherhood with joy and excitement, they also express fear and hesitation. This tension between fulfilling their expected roles and being unsure and hesitant about them exists in the projects. We claim that even if implicit and careful, these signs are important to recognize. However, it seems that higher education has failed to significantly undermine patriarchal and gender expectations.


Subject(s)
Arabs , Marriage , Mothers , Students , Humans , Female , Arabs/psychology , Israel , Marriage/psychology , Students/psychology , Mothers/psychology , Young Adult , Adult , Universities , Adolescent
11.
Viruses ; 16(5)2024 05 20.
Article in English | MEDLINE | ID: mdl-38793689

ABSTRACT

BACKGROUND AND AIMS: An increase in the number of cases of acute hepatitis of unknown origin (HUO) in children was observed in 2021. Adenovirus and adeno-associated virus 2 (AAV2) infections have been suggested as possible triggers. However, the potential etiology is still unclear. We aimed to characterize a cohort of children with HUO in Israel in view of the COVID-19 pandemic. METHOD: Demographics, clinical data, and laboratory results on the children compatible with the CDC criteria for HUO were collected by the established registry of the Ministry of Health. Available specimens were sent to the Central Virology Laboratory. RESULTS: A total of 39 children were included in the registry. A total of 20 were enrolled prospectively, in which human herpes virus 6 (HHV6) infection or reactivation was identified in 11/19, adenovirus was found in 4/19 of the cases, and AAV2 was detected in 2/16. Past COVID-19 exposure was recorded for 24/39 of the children. A total of 10 children underwent liver biopsy, and 8 were successfully treated with steroids and 2 underwent liver transplantation. CONCLUSIONS: The COVID-19 pandemic and the related containment measures combined with reactivation or active infection with other viruses could have been a trigger for the HUO outbreak. In our cohort, HHV6 was the most abundant finding.


Subject(s)
COVID-19 , SARS-CoV-2 , Humans , COVID-19/epidemiology , COVID-19/virology , Child , Female , Male , Child, Preschool , Infant , Israel/epidemiology , Adolescent , Herpesvirus 6, Human/physiology , Disease Outbreaks , Prospective Studies , Acute Disease/epidemiology , Pandemics
12.
Am J Mens Health ; 18(3): 15579883241253820, 2024.
Article in English | MEDLINE | ID: mdl-38794957

ABSTRACT

Being a man has been recognized as a salient risk factor for suicide. Adopting uncompromised masculine perceptions (i.e., conforming to the masculine gender role norms) may restrict emotional expressiveness in men, which, in turn, may contribute to depression and somatization symptoms. We examined the moderating role of psychological flexibility and alexithymia in the relationship of masculinity with depression and somatization symptoms. A sample of 119 men completed measures of masculinity, alexithymia (difficulty identifying and delivering subjective feelings), psychological flexibility, depression, and somatization symptoms in a cross-sectional design study. Psychological flexibility levels moderated the relationship between masculinity and depression symptoms: Masculinity contributed as positively associated with depression symptoms when psychological flexibility was low, but no such association was found at moderate or high levels of psychological flexibility. As a cognitive factor promoting adaptive emotional regulation, psychological flexibility might reduce depression symptoms among inflexible masculine men. Clinical implications relate to diagnosing at-risk subgroups and their treatment.


Subject(s)
Depression , Masculinity , Humans , Male , Israel , Adult , Cross-Sectional Studies , Depression/psychology , Young Adult , Middle Aged , Adaptation, Psychological , Surveys and Questionnaires , Affective Symptoms/psychology
13.
Harefuah ; 163(5): 327-330, 2024 May.
Article in Hebrew | MEDLINE | ID: mdl-38734949

ABSTRACT

INTRODUCTION: The number of medical cannabis licenses in Israel is increasing persistently (over 120,000 approved licenses in October 2022), reaching about 1.5% of adult population. Medical cannabis products are available in two main forms: inflorescence (administered by smoking or evaporation) and cannabis oil (administered sub-lingually). Data from the Israel ministry of health, regarding the split between these forms, show a major preference for inflorescence products over cannabis oils. This preference is increasing over time. This article reviews the main differences between the administration of these forms and their effects on the quality of treatment. It's conclusion is that for the most common cases of cannabis treatment, sublingual oils should be preferred and that the medical community has an important role in driving this change.


Subject(s)
Medical Marijuana , Humans , Medical Marijuana/administration & dosage , Israel , Cannabis , Plant Oils/administration & dosage , Administration, Sublingual , Adult , Marijuana Smoking/legislation & jurisprudence , Inflorescence , Drug Administration Routes
14.
Indian J Med Ethics ; IX(2): 130-135, 2024.
Article in English | MEDLINE | ID: mdl-38755772

ABSTRACT

This article looks at the October 2023 war on Gaza in the context of the effects of wars on healthcare systems. I will begin with a brief historical overview of the so-called Israeli-Palestinian conflict to clarify the special status of the Gaza Strip and the hostilities since October 7, 2023. This will be followed by a description of the major distinguishing characteristic of this war, namely, the systematic assault on the healthcare system. Finally, I will attempt to explain the conduct of this war using a necropolitical lens.


Subject(s)
Delivery of Health Care , Humans , Middle East , Israel , Arabs , Warfare , Armed Conflicts , Politics
15.
BMJ Paediatr Open ; 8(1)2024 May 15.
Article in English | MEDLINE | ID: mdl-38754896

ABSTRACT

OBJECTIVE: This study aims to examine the perspectives of neonatologists in Israel regarding resuscitation of preterm infants born at 22-24 weeks gestation and their consideration of parental preferences. The factors that influence physicians' decisions on the verge of viability were investigated, and the extent to which their decisions align with the national clinical guidelines were determined. STUDY DESIGN: Descriptive and correlative study using a 47-questions online questionnaire. RESULTS: 90 (71%) of 127 active neonatologists in Israel responded. 74%, 50% and 16% of the respondents believed that resuscitation and full treatment at birth are against the best interests of infants born at 22, 23 and 24 weeks gestation, respectively. Respondents' decisions regarding resuscitation of extremely preterm infants showed significant variation and were consistently in disagreement with either the national clinical guidelines or the perception of what is in the best interest of these newborns. Gender, experience, country of birth and the level of religiosity were all associated with respondents' preferences regarding treatment decisions. Personal values and concerns about legal issues were also believed to affect decision-making. CONCLUSION: Significant variation was observed among Israeli neonatologists regarding delivery room management of extremely premature infants born at 22-24 weeks gestation, usually with a notable emphasis on respecting parents' wishes. The current national guidelines do not fully encompass the wide range of approaches. The country's guidelines should reflect the existing range of opinions, possibly through a broad survey of caregivers before setting the guidelines and recommendations.


Subject(s)
Attitude of Health Personnel , Infant, Extremely Premature , Neonatologists , Resuscitation Orders , Humans , Israel , Infant, Newborn , Female , Male , Resuscitation Orders/ethics , Surveys and Questionnaires , Adult , Fetal Viability , Decision Making , Parents/psychology , Resuscitation , Neonatology , Gestational Age
17.
Harefuah ; 163(5): 295-297, 2024 May.
Article in Hebrew | MEDLINE | ID: mdl-38734942

ABSTRACT

INTRODUCTION: During the global outbreak of coronavirus disease 2019 pandemic, people sought ways to disinfect their domestic and public surroundings. One of the sanitation options included the usage of ultraviolet-C (UVC) lamps since UVC radiation has been shown to effectively inactivate the SARS-Coronavirus. UVC radiation may also be effective against the SARS-CoV-2 virus. Here we report four cases of bilateral photokeratitis due to the improper usage of UV lamps during the first outbreak of COVID-19 in Israel. METHODS: We collected 4 case reports from patients who were diagnosed with bilateral photokeratitis due to improper usage of UV lamps in their domestic environment from May to December 2020 during the first outbreak of COVID-19 in Israel. RESULTS: A total of four patients presented with signs and symptoms of bilateral photokeratitis after exposure to UV lamps. DISCUSSION: Acute exposure of UVC to the cornea may cause "burns", known as photokeratitis. The signs of photokeratitis usually appear a few hours after the exposure. Precautious steps to educate the population must include using protective eyewear in any exposure to UV light and avoiding the use of germicidal lamps in public locations with exposure to the population.


Subject(s)
COVID-19 , Keratitis , Ultraviolet Rays , Humans , Ultraviolet Rays/adverse effects , COVID-19/prevention & control , Male , Israel/epidemiology , Female , Keratitis/etiology , Middle Aged , Adult
18.
Harefuah ; 163(5): 321-322, 2024 May.
Article in Hebrew | MEDLINE | ID: mdl-38734947

ABSTRACT

INTRODUCTION: In his important article, Prof. G. Eshel describes the story of three Jewish physicians who returned to Nazi Germany to complete their MD thesis despite laws prohibiting Jewish students from German Universities. The three physicians completed their MD thesis examination with the help of three German Professors who supported them regardless of the laws banning Jewish students. The three physicians risked their lives by returning to Nazi Germany, as did the three professors who supported them. The three physicians returned to Palestine upon completion of the requirement for their medical licensing and continued to contribute to the medical system for many years in the State of Israel. The determination of the three Jewish physicians and their courage teaches us an important lesson on the motivation of young doctors to complete their education and practice medicine. The support of the German professors created some lights in the great darkness of the Nazi regime. Generations of physicians took a stand on non-medical issues and contributed to social justice and the wellbeing of individuals beyond medical care. We should all continue this legacy.


Subject(s)
Education, Medical , Jews , National Socialism , Physicians , National Socialism/history , Jews/history , Humans , Germany , History, 20th Century , Physicians/history , Education, Medical/history , Israel
19.
JAMA Netw Open ; 7(5): e2410721, 2024 May 01.
Article in English | MEDLINE | ID: mdl-38753331

ABSTRACT

Importance: Preterm children are at risk for neurodevelopment impairments. Objective: To evaluate the effect of a music therapy (MT) intervention (parent-led, infant-directed singing) for premature children during the neonatal intensive care unit (NICU) stay and/or after hospital discharge on language development at 24 months' corrected age (CA). Design, Setting, and Participants: This predefined secondary analysis followed participants in the LongSTEP (Longitudinal Study of Music Therapy's Effectiveness for Premature Infants and Their Caregivers) randomized clinical trial, which was conducted from August 2018 to April 2022 in 8 NICUs across 5 countries (Argentina, Colombia, Israel, Norway, and Poland) and included clinic follow-up visits and extended interventions after hospital discharge. Intervention: Participants were children born preterm (<35 weeks' gestation) and their parents. Participants were randomized at enrollment to MT with standard care (SC) or SC alone; they were randomized to MT or SC again at discharge. The MT was parent-led, infant-directed singing tailored to infant responses and supported by a music therapist and was provided 3 times weekly in the NICU and/or in 7 sessions across 6 months after discharge. The SC consisted of early intervention methods of medical, nursing, and social services, without MT. Main Outcome and Measures: Primary outcome was language development, as measured by the Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III) language composite score, with the remaining BSID-III composite and subscale scores as the secondary outcomes. Group differences in treatment effects were assessed using linear mixed-effects models using all available data. Results: Of 206 participants (103 female infants [50%]; mean [SD] GA, 30.5 [2.7] weeks), 51 were randomized to MT and 53 to SC at enrollment; at discharge, 52 were randomized to MT and 50 to SC. A total of 112 (54%) were retained at the 24 months' CA follow-up. Most participants (79 [70%] to 93 [83%]) had BSID-III scores in the normal range (≥85). Mean differences for the language composite score were -2.36 (95% CI, -12.60 to 7.88; P = .65) for the MT at NICU with postdischarge SC group, 2.65 (95% CI, -7.94 to 13.23; P = .62) for the SC at NICU and postdischarge MT group, and -3.77 (95% CI, -13.97 to 6.43; P = .47) for the MT group at both NICU and postdischarge. There were no significant effects for cognitive or motor development. Conclusions and Relevance: This secondary analysis did not confirm an effect of parent-led, infant-directed singing on neurodevelopment in preterm children at 24 months' CA; wide CIs suggest, however, that potential effects cannot be excluded. Future research should determine the MT approaches, implementation time, and duration that are effective in targeting children at risk for neurodevelopmental impairments and introducing broader measurements for changes in brain development. Trial Registration: ClinicalTrials.gov Identifier: NCT03564184.


Subject(s)
Infant, Premature , Music Therapy , Humans , Music Therapy/methods , Female , Male , Infant, Newborn , Infant , Intensive Care Units, Neonatal , Child, Preschool , Language Development , Longitudinal Studies , Child Development/physiology , Neurodevelopmental Disorders/prevention & control , Colombia , Norway , Israel
20.
Pharmacoepidemiol Drug Saf ; 33(6): e5817, 2024 Jun.
Article in English | MEDLINE | ID: mdl-38783416

ABSTRACT

PURPOSE: It has been suggested that statins may exert thermo-protective effects that can reduce mortality on hot days. We aimed to examine the relationship between statin adherence and mortality in days with high temperature. METHODS: Utilizing data from a prior historical new-user cohort study, we analyzed a cohort of 229 918 individuals within a state-mandated health provider in Israel who initiated statin therapy between 1998 and 2006. Adherence to statins was assessed through the mean proportion of days covered (PDC) with statins during the follow-up period. The study's primary outcome was all-cause mortality during hot days. RESULTS: During the study follow-up period, a total of 13 165 individuals (5.7%) died. In a multivariable model, a 10% increase in PDC with statins was associated with an HR of (0.85; 95% CI: 0.72-1.00) for deaths (n = 16) in extremely hot days (≥39°C). This association was numerically stronger compared to HR = 0.94 (0.93-0.94) in cooler days and displayed a significant difference between sexes. In males, the fully-adjusted HR for a 10% increase in PDC with statins was 0.66 (0.45-0.95), while in women, it was 0.98 (0.78-1.23). In contrast, no such effect modification was observed for death in cooler days. CONCLUSIONS: These findings align with earlier research, supporting the notion that adherence with statin treatment may be associated with a reduced risk of death during extremely hot days, particularly among men.


Subject(s)
Hot Temperature , Hydroxymethylglutaryl-CoA Reductase Inhibitors , Medication Adherence , Humans , Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use , Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage , Male , Female , Israel/epidemiology , Middle Aged , Medication Adherence/statistics & numerical data , Aged , Hot Temperature/adverse effects , Cohort Studies , Mortality/trends , Follow-Up Studies , Adult , Sex Factors
SELECTION OF CITATIONS
SEARCH DETAIL
...