Subject(s)
Carcinoma/genetics , Chromosomes, Human, Pair 9/genetics , Genetic Variation/genetics , Keratoacanthoma/genetics , Protein Serine-Threonine Kinases/genetics , Receptors, Transforming Growth Factor beta/genetics , Skin Diseases/genetics , Carcinoma/ethnology , Case-Control Studies , Germ-Line Mutation/genetics , Humans , Keratoacanthoma/ethnology , Patched Receptors , Polymorphism, Single Nucleotide/genetics , Receptor, Transforming Growth Factor-beta Type I , Receptors, Cell Surface/genetics , Scotland , Skin Diseases/ethnologyABSTRACT
BACKGROUND: This is the first incidence report of keratoacanthoma (KA) in a Japanese ethnic population. METHODS: The study was designed as a 5-year prospective incidence study using an island-wide survey of Japanese residents in Kauai, Hawaii, during the years 1983 through 1987. RESULTS: Eleven Japanese residents of Kauai, three men and eight women, had KA. The crude incidence is 22.1 per 100,000 Japanese Kauaiian population. Two thirds of the lesions were on the extremities. No recurrence was noted, but a nonmelanoma skin cancer developed in some patients. CONCLUSIONS: The incidence of KA in a Japanese ethnic population is not low. Ultraviolet light exposure must, in part, contribute to the development of KA. This is supported by fact that the incidence of KA in Japanese residents in Kauai is much higher than in Japan and that most of the KAS appear on exposed skin.
Subject(s)
Keratoacanthoma/ethnology , Aged , Aged, 80 and over , Female , Hawaii/epidemiology , Humans , Incidence , Japan/ethnology , Keratoacanthoma/epidemiology , Male , Middle Aged , Prospective StudiesABSTRACT
BACKGROUND: Non-melanoma skin cancer is the most common malignancy in the white population of the United States with an estimated 700,000 new cases each year. Regrettably, data on minority racial groups are either scarce or lacking entirely. METHODS: This study was designed as a 5-year prospective incidence study of non-melanoma skin cancer and keratoacanthoma by using an island-wide survey of Kauai's Filipino residents and covers the years of 1983 to 1987. RESULTS: Seven basal cell carcinoma (incidence: 12.3/100,000), one squamous cell carcinoma (incidence: 1.8/100,000) and four keratoacanthoma (incidence: 7/100,000) patients are reported. CONCLUSIONS: To the best of our knowledge, this is the first population-based incidence report on non-melanoma skin cancer and keratoacanthoma in this population.
Subject(s)
Bowen's Disease/ethnology , Bowen's Disease/epidemiology , Carcinoma, Basal Cell/ethnology , Carcinoma, Basal Cell/epidemiology , Carcinoma, Squamous Cell/ethnology , Carcinoma, Squamous Cell/epidemiology , Keratoacanthoma/ethnology , Keratoacanthoma/epidemiology , Skin Neoplasms/ethnology , Skin Neoplasms/epidemiology , Aged , Aged, 80 and over , Bowen's Disease/pathology , Carcinoma, Basal Cell/pathology , Carcinoma, Squamous Cell/pathology , Female , Hawaii , Humans , Incidence , Keratoacanthoma/pathology , Male , Middle Aged , Philippines/ethnology , Prospective Studies , Skin Neoplasms/pathologyABSTRACT
Standard microlymphocytic cytotoxic test was used in 43 cases of solitary keratoacanthoma. Increased incidence of HLA-B16 and HLA-B18 antigens was established. Presence of HLA-A2 was shown to adversely influence the course of the disease.
