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1.
Semin Dial ; 33(1): 5-9, 2020 01.
Article in English | MEDLINE | ID: mdl-31943368

ABSTRACT

Broadly defined public policy has been said to be whatever "governments choose to do or not to do" As applied to healthcare, public policy can be traced back to the 4000-year-old Code of Hammurabi. As it applies to dialysis care its history is barely 50 years old since national coverage for end-stage renal disease (ESRD) was legislated as Public Law 92-603 in 1972. As with most healthcare policy changes, it was a result of medical progress which had changed renal function replacement by dialysis from its rudimentary beginnings during the Second World War into an experimental acute life-saving procedure in the 1950s and to an established life-sustaining treatment for the otherwise fatal disease of uremia in the 1960s that was limited by its costs. Since 1973, the Medicare ESRD Program has saved the lives of thousands of individuals, a compassionate achievement that has come at increasing costs which have exceeded all estimates and evaded containment. Apart from cost containment, policy changes in dialysis care have been directed at improving its safety and adequacy. Some of the results of these changes are evident as one compares the outcomes and complications of dialysis encountered in the 1970s to those in the present; others, particularly those related to vascular access and hospitalization rates have improved modestly. This article recounts the historical background in which national coverage for dialysis care was developed, legislated and has evolved over the past 50 years.


Subject(s)
Delivery of Health Care/history , Health Policy/history , Kidney Failure, Chronic/history , Renal Dialysis/history , History, 20th Century , History, 21st Century , Humans , Kidney Failure, Chronic/therapy , United States
2.
Semin Dial ; 32(5): 396-401, 2019 09.
Article in English | MEDLINE | ID: mdl-30968459

ABSTRACT

In this essay, we describe the evolution of attitudes toward dialysis discontinuation in historical context, beginning with the birth of outpatient dialysis in the 1960s and continuing through the present. From the start, attitudes toward dialysis discontinuation have reflected the clinical context in which dialysis is initiated. In the 1960s and 1970s, dialysis was only available to select patients and concerns about distributive justice weighed heavily. Because there was strong enthusiasm for new technology and dialysis was regarded as a precious resource not to be wasted, stopping treatment had negative moral connotations and was generally viewed as something to be discouraged. More recently, dialysis has become the default treatment for advanced kidney disease in the United States, leading to concerns about overtreatment and whether patients' values, goals, and preferences are sufficiently integrated into treatment decisions. Despite the developments in palliative nephrology over the past 20 years, dialysis discontinuation remains a conundrum for patients, families, and professionals. While contemporary clinical practice guidelines support a person-centered approach toward stopping dialysis treatments, this often occurs in a crisis when all treatment options have been exhausted. Relatively little is known about the impact of dialysis discontinuation on the experiences of patients and families and there is a paucity of high-quality person-centered evidence to guide practice in this area. Clinicians need better insights into decision-making, symptom burden, and other palliative outcomes that patients might expect when they discontinue dialysis treatments to better support decision-making in this area.


Subject(s)
Kidney Failure, Chronic/history , Kidney Failure, Chronic/therapy , Patient-Centered Care/history , Renal Dialysis/history , Withholding Treatment/history , Attitude to Health , Decision Making , History, 20th Century , History, 21st Century , Humans , United States
4.
J Natl Med Assoc ; 111(4): 352-362, 2019 Aug.
Article in English | MEDLINE | ID: mdl-30777381

ABSTRACT

INTRODUCTION: The first successful kidney transplant in humans was performed in 1954. In the following 25 years, the biomedical, ethical, and social implications of kidney transplantation were widely discussed by both healthcare professionals and the public. Issues relating to race, however, were not commonly addressed, representing a "blind spot" regarding racial disparities in access and health outcomes. METHODS: Through primary sources in the medical literature and lay press, this paper explores the racial dynamics of kidney transplantation in the 1950-1970s in the United States as the procedure grew from an experimental procedure to the standard of care for patients in end-stage renal disease (ESRD). RESULTS & DISCUSSION: An extensive search of the medical literature found very few papers about ESRD, dialysis, or renal transplant that mentioned the race of the patients before 1975. While the search did not reveal whether race was explicitly used in determining patient access to dialysis or transplant, the scant data that exist show that African-Americans disproportionately developed ESRD and were underrepresented in these early treatment populations. Transplant outcome data in the United States failed to include race demographics until the late 1970s. The Social Security Act of 1972 (PL 92-603) extended Medicare coverage to almost all Americans with ESRD and led to a rapid increase in both dialysis and kidney transplantation for African-Americans in ESRD, but disparities persist today.


Subject(s)
Black or African American/statistics & numerical data , Healthcare Disparities/history , Kidney Failure, Chronic/ethnology , Kidney Transplantation/history , Black or African American/history , Dialysis , Health Services Accessibility/history , Healthcare Disparities/ethnology , History, 20th Century , Humans , Kidney Failure, Chronic/history , Kidney Failure, Chronic/surgery , Medicare/history , Medicare/legislation & jurisprudence , United States
5.
Adv Chronic Kidney Dis ; 25(6): 474-479, 2018 11.
Article in English | MEDLINE | ID: mdl-30527544

ABSTRACT

The history of chronic dialysis in the United States highlights the impact nephrology leaders have on improving kidney disease care. Belding Scribner and his Seattle team transformed end-stage renal disease from a fatal illness to a treatable condition with use of the first successful Scribner shunt in 1960. Advances in dialysis machines emerged from Les Babb and Richard Drake finding ways to treat more patients. Innovative nephrology leaders foster incremental change leading to the technically complex, life-sustaining treatments that are widely available to end-stage renal disease patients today. The Nephrology Oral History Project consists of interviews with patient, nurse, and nephrologist pioneers who have witnessed and contributed to these advancements in kidney disease care. This article includes Nephrology Oral History Project excerpts illustrating leadership contributions to dialysis machines, peritoneal dialysis catheters, and treatment best practices. In addition to individual contributions, improvements in treatment also come from patient and provider organizations leading the way and collectively advocating for change. Nephrology leaders continue to play a crucial role in improving dialysis outcomes and quality of life.


Subject(s)
Kidney Failure, Chronic/history , Leadership , Nephrology/history , Renal Dialysis/history , History, 20th Century , History, 21st Century , Humans , Kidney Failure, Chronic/therapy , United States
8.
Int J Artif Organs ; 40(7): 313-322, 2017 Jul 05.
Article in English | MEDLINE | ID: mdl-28685808

ABSTRACT

From its introduction in 1943 and until the late 1970s, hemodialysis (HD) has been a lengthy and cumbersome treatment administered by a few skilled physicians and technicians to a very limited number of terminal kidney patients. The technological innovations introduced over the years made HD a treatment administered and supervised by nursing personnel to a very large numbers of kidney patients, hopefully until recovery of kidney functions or kidney transplantation. In 2013, it is estimated that 2.250.00 kidney patients were treated worldwide, and their number is steadily increasing. Shortage of transplant kidneys and quality of current treatments has contributed to increasing the survival of HD patients. Today, it is not unusual to find patients who have been on HD for longer than twenty years. All this generated the feeling that performance of membranes and dialysis technology has reached its limit. Recently, the increasing economic burden of healthcare caused by people ageing and the increasing incidence of degenerative diseases (e.g. diabetes and cardiovascular diseases), and the economic crisis has pushed many governments and health insurances to cut resources for healthcare. The main consequence is that investments in research and development in HD have been significantly reduced. The question is whether there is indeed no need for innovation in HD.In this paper, it is discussed how the paradigm of HD has changed and what possibly are now the drivers for innovation in HD. A few ideas are proposed that could be developed by adapting existing technologies to the future needs of HD.


Subject(s)
Kidney Failure, Chronic/history , Kidney Transplantation/history , Renal Dialysis/history , Anniversaries and Special Events , Forecasting , History, 20th Century , History, 21st Century , Humans , Kidney Failure, Chronic/therapy , Kidney Transplantation/trends , Renal Dialysis/trends
9.
Tech Vasc Interv Radiol ; 20(1): 2-8, 2017 Mar.
Article in English | MEDLINE | ID: mdl-28279405

ABSTRACT

Dialysis vascular access management in the United States changed significantly after National Kidney Foundation-Kidney Disease Outcome Quality Initiative (NKF-KDOQI) clinical practice guidelines were first published in 1997. The Centers for Medicare and Medicaid Service adopted these guidelines and in collaboration with the End-Stage Renal Disease Networks established the Fistula First Breakthrough Initiative (FFBI) in 2003 to improve the rate of arteriovenous fistula use over arteriovenous graft and central venous catheter in the dialysis population. The implementation of guidelines and FFBI has led to a significant increase in the arteriovenous fistula use in the prevalent dialysis population. The guidelines are criticized for being opinion based and often impractical. Over the past 2 decades, the patient population undergoing dialysis has become older with complex comorbidities and challenges for creating an ideal vascular access. Advancing knowledge about access pathophysiology, improved treatment options, and improved process of care with team approach model point toward diminishing relevance of few of the existing guidelines. Moreover, several guidelines remain controversial and may be leading to clinical decisions that may be unfavorable to the patients. The review discusses the historical aspect of vascular access care in the United States and evolution of current practice standards and controversies surrounding few of these guidelines in the current time.


Subject(s)
Arteriovenous Shunt, Surgical/standards , Blood Vessel Prosthesis Implantation/standards , Catheterization, Central Venous/standards , Kidney Failure, Chronic/therapy , Practice Guidelines as Topic/standards , Renal Dialysis/standards , Aged , Arteriovenous Shunt, Surgical/adverse effects , Arteriovenous Shunt, Surgical/history , Blood Vessel Prosthesis Implantation/adverse effects , Blood Vessel Prosthesis Implantation/history , Catheterization, Central Venous/adverse effects , Catheterization, Central Venous/history , Female , Guideline Adherence/standards , History, 20th Century , History, 21st Century , Humans , Kidney Failure, Chronic/diagnosis , Kidney Failure, Chronic/epidemiology , Kidney Failure, Chronic/history , Male , Middle Aged , Patient Selection , Practice Patterns, Physicians'/standards , Renal Dialysis/history , Risk Factors , Treatment Outcome , United States/epidemiology
10.
Pediatr Res ; 81(1-2): 259-264, 2017 01.
Article in English | MEDLINE | ID: mdl-27732587

ABSTRACT

Successful renal transplantation is the optimal treatment for chronic kidney failure, but this was not always so for children. Beginning with the first kidney transplants in the 1950s, children experienced poorer patient and graft survival rates than adult patients. But over the last 6 decades, an improved understanding of the immune system which has steered pediatric multi-center clinical/pharmacokinetic and mechanistic studies that have sculpted our immunosuppression with markedly better patient and graft survivals. In addition, uniquely pediatric issues related to growth, development, neurocognitive maturation, increased complications from primary viral infections, and comorbid congenital/inherited disorders, are now diagnosed and effectively managed in these children. Refined pretransplant preparation (vaccinations for preventable diseases, attention to cognitive delays, effective dialysis and nutrition) improved donor selection, and more potent immunosuppression have all contributed to enhanced outcomes. Similarly, improvements in pediatric surgical techniques, postoperative care and better antiviral prophylaxis have all shortened hospitalizations and reduced morbidity. Today pediatric kidney transplant outcomes are markedly improved and younger children today experience better long-term graft survival than adults! While difficult problems remain, we have made tremendous progress and anticipate even more advances in the future of pediatric kidney transplantation.


Subject(s)
Kidney Failure, Chronic/surgery , Kidney Transplantation/history , Kidney Transplantation/methods , Nephrology/history , Child , Child, Preschool , Graft Survival , History, 20th Century , History, 21st Century , Humans , Immunosuppression Therapy , Immunosuppressive Agents/therapeutic use , Infant , Kidney Failure, Chronic/history , Kidney Transplantation/adverse effects , Survival Rate , Treatment Outcome
11.
Urologe A ; 55(10): 1353-1359, 2016 Oct.
Article in German | MEDLINE | ID: mdl-27518791

ABSTRACT

The history of kidney transplantation is a history of many unsuccessful efforts and setbacks, but also the history of perseverance, pioneering spirit, and steadfast courage. The first successful transplantation of a dog kidney was done by the Austrian Emerich Ullmann (1861-1937) in 1902. The kidney was connected to the carotid artery of the dog and the ureter ended freely. The organ produced urine for a couple of days before it died. In 1909, there were efforts to transplant human kidneys from deceased patients to monkeys and in the following year the first xenotransplantation in humans was completed. Different kinds of donors were tried: dogs, monkeys, goats and lambs, all without success. In 1939, the first transplantation from a deceased human donor was done by the Russion Yurii Voronoy, the patient survived for only a couple of days, and the organ never worked. In 1953, the first temporarily successful transplantation of a human kidney was performed by Jean Hamburger in Paris. A 16-year-old boy received the kidney of his mother as living donor transplantation. Then in 1954, a milestone was made with the first long-term successful kidney transplantation by Joseph Murray: the transplantation was done between monozygotic twins; the organ survived for 8 years. For his efforts in kidney transplantation, Murray was honored with the Nobel Prize in medicine in 1990. In 1962, the first kidney transplantation between genetically nonrelated patients was done using immunosuppression and in 1963 the first kidney transplantation in Germany was done by Reinhard Nagel and Wilhelm Brosig in Berlin. The aim of this article is to present the history of kidney transplantation from the beginning until today.


Subject(s)
Kidney Failure, Chronic/history , Kidney Failure, Chronic/therapy , Kidney Transplantation/history , Nephrology/history , Europe , History, 19th Century , History, 20th Century , History, 21st Century , Humans
13.
Blood Purif ; 41(4): I-V, 2016.
Article in English | MEDLINE | ID: mdl-26756788

ABSTRACT

The University of Alberta (UofA) in Edmonton, Canada has a rich and productive history supporting the development of critical care medicine, nephrology and the evolving subspecialty of critical care nephrology. The first hemodialysis program for patients with chronic renal failure in Canada was developed at the University of Alberta Hospital. The UofA is also recognized for its early pioneering work on the diagnosis, etiology and outcomes associated with acute kidney injury (AKI), the development of a diagnostic scheme renal allograft rejection (Banff classification), and contributions to the Renal Disaster Relief Task Force. Edmonton was one of the first centers in Canada to provide continuous renal replacement therapy. This has grown into a comprehensive clinical, educational and research center for critical care nephrology. Critical care medicine in Edmonton now leads and participates in numerous critical care nephrology initiatives dedicated to AKI, renal replacement therapy, renal support in solid organ transplantation, and extracorporeal blood purification. Critical care medicine in Edmonton is recognized across Canada and across the globe as a leading center of excellence in critical care nephrology, as an epicenter for research innovation and for training a new generation of clinicians with critical care nephrology expertise.


Subject(s)
Acute Kidney Injury/history , Critical Care/history , Kidney Failure, Chronic/history , Kidney Transplantation/history , Nephrology/history , Renal Dialysis/history , Acute Kidney Injury/pathology , Acute Kidney Injury/therapy , Alberta , Critical Care/methods , History, 20th Century , History, 21st Century , Humans , Kidney Failure, Chronic/pathology , Kidney Failure, Chronic/therapy , Kidney Transplantation/methods , Kidney Transplantation/statistics & numerical data , Nephrology/instrumentation , Nephrology/methods , Renal Dialysis/instrumentation , Renal Dialysis/methods
14.
Contrib Nephrol ; 186: 1-12, 2015.
Article in English | MEDLINE | ID: mdl-26283554

ABSTRACT

The constant side method of access cannulation in hemodialysis, popularly known as the 'buttonhole' method, has an interesting history. Dr. Zbylut J. Twardowski, a Polish nephrologist, discovered this technique by pure serendipity in 1972. A patient with a complicated vascular access history and limited options for cannulation was repeatedly 'stuck' at the same sites by a nurse. Soon it was noticed that the cannulation at the same spot became easier with time. Since the needles were being reused, the sharpness of the needles decreased with time and the bluntness of the needle seemed to minimize the damage to the cannulation tract (another serendipity!). This method soon became popular among patients, and many patients started using this technique. This chapter traces the invention of this technique and its subsequent development following Dr. Twardowski's emigration to the USA.


Subject(s)
Arteriovenous Shunt, Surgical , Catheterization, Peripheral/history , Kidney Failure, Chronic/history , Renal Dialysis/history , Catheterization, Peripheral/methods , History, 20th Century , History, 21st Century , Humans , Kidney Failure, Chronic/therapy , Poland , Renal Dialysis/methods
16.
Clin J Am Soc Nephrol ; 10(2): 326-30, 2015 Feb 06.
Article in English | MEDLINE | ID: mdl-25278550

ABSTRACT

The medical director has been a part of the fabric of Medicare's ESRD program since entitlement was extended under Section 299I of Public Law 92-603, passed on October 30, 1972, and implemented with the Conditions for Coverage that set out rules for administration and oversight of the care provided in the dialysis facility. The role of the medical director has progressively increased over time to effectively extend to the physicians serving in this role both the responsibility and accountability for the performance and reliability related to the care provided in the dialysis facility. This commentary provides context to the nature and expected competencies and behaviors of these medical director roles that remain central to the delivery of high-quality, safe, and efficient delivery of RRT, which has become much more intensive as the dialysis industry has matured.


Subject(s)
Delivery of Health Care, Integrated/trends , Kidney Failure, Chronic/therapy , Nephrology/trends , Physician Executives/trends , Physician's Role , Quality of Health Care/trends , Clinical Competence , Delivery of Health Care, Integrated/history , Delivery of Health Care, Integrated/standards , History, 20th Century , History, 21st Century , Humans , Kidney Failure, Chronic/diagnosis , Kidney Failure, Chronic/history , Leadership , Medicare , Nephrology/history , Nephrology/standards , Physician Executives/history , Physician Executives/standards , Physician's Role/history , Quality of Health Care/history , Quality of Health Care/standards , United States , Workforce
18.
Acta Med Hist Adriat ; 11(1): 149-58, 2013.
Article in English | MEDLINE | ID: mdl-23883091

ABSTRACT

The early and unexpected death of Wolfgang Amadeus Mozart (Salzburg, 1756 - Vienna, 1791) was a mystery from the very first day and the subject of wildest speculations and adventurous assertions. Over the last 100 years, medical science has investigated the physical sufferings and the mysterious death of Mozart with increasing intensity. The aim of this article was to recreate Mozart's pathography relying on the his correspondence with father Leopold and sister Nannerl and on reports from his physicians and contemporaries. The rumour that Mozart was poisoned followed shortly after his death on 5 December 1791, at the age of 35, and has survived to this day. The alleged culprits were his physician van Swieten, Mozart's freemasons lodge, and the Imperial Chapel Master Salieri. Mozart however died of chronic kidney disease and ultimately of uraemia. If kidney damage reaches a critical point, even a minimum additional stress can lead to its failure. This usually occurs in the fourth decade of life. Next time we listen to Mozart, we should remember that this apparently happy person was actually a precocious boy, ripped of his childhood, whose short life was an endless chain of complaints, fatigue, misery, concern, and malady.


Subject(s)
Famous Persons , Kidney Failure, Chronic/history , Uremia/history , Austria , History, 18th Century , Music/history
19.
Wien Med Wochenschr ; 163(11-12): 255-65, 2013 Jun.
Article in German | MEDLINE | ID: mdl-23591854

ABSTRACT

During the past years new developments in peritoneal dialysis (PD) technique have resulted in continuous improvement of patient outcome. The importance of salt and fluid balance, residual renal function and peritoneal glucose load are of increasing interest, whereas small solute clearances have lost importance. In patients with high peritoneal transport rates automated PD (APD) is indicated. However, APD can also be chosen as initial PD treatment since recent studies show comparable or even better survival as compared to continuous ambulatory PD patients. Alternative PD solutions improve peritoneal ultrafiltration (icodextrin), reduce peritoneal glucose load (amino acid solution, icodextrin) and protect the peritoneal membrane (solutions with low concentration of glucose degradation products). Infection risk can be reduced when using antibiotic creams, but resistances should be considered. Ongoing studies will clarify if non-antibiotic agents, e.g. medihoney, are effective in preventing PD-associated infections. Due to these improvements PD and hemodialysis have become equivalent treatments.


Subject(s)
Dialysis Solutions/history , Kidney Failure, Chronic/history , Peritoneal Dialysis, Continuous Ambulatory/history , Peritoneal Dialysis, Continuous Ambulatory/trends , Austria , History, 20th Century , History, 21st Century , Humans , Kidney Failure, Chronic/therapy , Prognosis , Water-Electrolyte Balance/physiology
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