Tumores anexiales incidentales en cirugía abdominal / Incidental adnexal tumors in abdominal surgery

La posibilidad de encontrar una neoplasia benigna o maligna del ovario, de forma inesperada durante una intervención quirúrgica abdominal, es una realidad para todos los especialistas en cirugía. Si bien en muchos casos se tratará de una lesión benigna, el riesgo de cáncer no debe subestimarse, ya que, por ejemplo, la ruptura intraoperatoria de una lesión quística maligna puede reestadificar a una paciente con cáncer de ovario del estadio IA al IC, con todas las consecuencias que esto implica, como la necesidad de requerir quimioterapia adyuvante y tener un peor pronóstico. Por otro lado, en mujeres premenopáusicas debe discutirse con la familia o la paciente (idealmente) el riesgo e implicaciones de la ooforectomía uni o bilateral, incluso si esto amerita dejar el quirófano para obtener el consentimiento, o posponer el procedimiento definitivo para un segundo tiempo. La consulta intraoperatoria a un ginecólogo, siempre que sea posible, se debe llevar a cabo con el fin de respaldar la conducta adoptada. Conocer el manejo adecuado de las masas anexiales encontradas de forma incidental durante una cirugía abdominal, es una prioridad para todos los cirujanos generales.

The possibility of finding a benign or malignant neoplasm of the ovary unexpectedly during abdominal surgery is a reality for all specialists in surgery. Although in many cases it will be a benign lesion, the risk of cancer should not be underestimated, since, for example, the intraoperative rupture of a malignant cystic lesion may well re-stage a patient with ovarian cancer from stage IA to IC, with the consequences that this implies, such as the need for adjuvant chemotherapy and a worse prognosis. On the other hand, in premenopausal women, the risk and implications of unilateral or bilateral oophorectomy should be discussed with the family or the patient (ideally), even if this implies leaving the operating room to obtain consent, or postponing the definitive procedure for a second time. Intraoperative consultation with a gynecologist, whenever possible, should be carried out in order to support the adopted behavior. Knowing the proper management of adnexal masses found incidentally during abdominal surgery is a priority for all general surgeons.

Ovarian metastasis from colorectal adenocarcinoma / Metástase ovariana de adenocarcinoma colorretal

Introduction: Ovarian metastases of gastrointestinal origin, also called Krukenberg tumors, have a guarded prognosis. Physicians need to look for alternatives in diagnosis and treatment for this clinical condition in order to improve the outcome of the patients. Objectives: To report the experience of the authors in the treatment of these patients, and to perform a review of the literature on the epidemiology, clinical presentation, diagnosis, treatment, and prognosis for ovarian metastases from colorectal cancer. Methods: We collected clinical information regarding the patients treated for ovarian metastasis from colorectal adenocarcinoma at our coloproctology service, and performed a search on the PubMed database using the terms colorectal cancer, ovarian metastasis, Krukenberg tumor and surgery. Conclusion: Large abdominal tumors are the most frequent presentation of ovarian metastasis from colorectal cancer. The diagnosis is based on a histopathological analysis, levels of carcinoembryonic antigen (CEA) and cancer antigen 125 (CA-125), and immunohistochemical studies for the cytokeratin 20 (CK20), caudal-type homeobox 2 (CDX2) and vilina markers. Citoreductive surgical procedures are the most promising approach to treatment, with the highest impact on overall survival. The prognosis is negatively influenced by the extent of the metastasis, by citoreductive surgical procedures with persistence of macro- or microscopic foci of the disease, and by low scores on the general well-being index of the patient. (AU)

Introdução: As metástases ovarianas de tumores gastrointestinais, também chamadas de tumores de Krukenberg, são neoplasias de prognóstico reservado. Exigem conhecimento de alternativas diagnósticas e terapêuticas para garantir melhora da sobrevida das pacientes. Objetivos: Relatar a experiência dos autores no tratamento dessas pacientes, e fazer uma revisão da literatura sobre a epidemiologia, apresentação clínica, diagnóstico, tratamento e prognóstico das metástases ovarianas do câncer colorretal. Métodos: Foi realizada uma coleta de informações clínicas de pacientes tratados por metástases ovarianas de adenocarcinoma colorretal em nosso serviço de coloproctologia, em conjunto com uma pesquisa na base de dados PubMed com os termos colorectal cancer, ovarian metastasis, Krukenberg tumor, e surgery. Conclusão: Volumosas massas abdominais constituem a principal apresentação clínica da doença. As alternativas diagnósticas incluem a avaliação histopatológica, a identificação dos níveis de antígeno cárcino-embriônico (ACE) e de antígeno de câncer 125 (CA-125), e exame imunoistoquímico de espécimes cirúrgicos para os marcadores citoqueratina 20 (CK20), homeobox 2 do tipo caudal (CDX2), e vilina. O tratamento citorredutor completo demonstrou o maior impacto na sobrevida dos pacientes. O prognóstico é influenciado negativamente pela extensão da doença metastática, por cirurgia citorredutiva com persistência focos microscópicos ou macroscópicos da doença, e baixo escore de índice de bem-estar geral do paciente. (AU)

Krukenberg tumor as an incidental finding in a full-term pregnancy: a case report.

BACKGROUND: Krukenberg tumor is a rare metastatic tumor of the ovary with histopathological features known as signet ring cells. It usually develops in women around 45 years of age. However, here we describe an uncommon case in a 38-year-old pregnant woman. We report this case due to our unusual findings, the uncommon presentation in this younger age bracket, its diagnostic challenge, and poor prognosis. CASE PRESENTATION: We describe a unique case of a young Mexican woman with a history of painful vaginal bleeding at 13 weeks of pregnancy and treated for abruptio placentae. In her routine prenatal visit at week 20 of pregnancy, she was found to have a uterine fundus exceeding the expected measure for her gestational age and was referred to the hospital to discard polyhydramnios. Upon admission, a pelvic ultrasound was performed displaying normal findings in a 25-week pregnancy, and also showing bilateral enlarged ovaries with heterogeneous echogenicity. Magnetic resonance imaging revealed a left tumoral lesion with dimensions of 22.1 × 13.6 × 16.3 cm presenting regular lobulated contours with displacement of peripheral structures and mild compression of the bladder, the left ureter, and the inferior vena cava. The lesion was heterogeneous with irregular borders. The patient was scheduled for a cesarean section; during the operation, the abdominal cavity showed bilateral tumors compatible with MRI findings. The ovarian tumors were sent to pathology, and the results showed poorly differentiated mucinous adenocarcinoma (World Health Organization grade III) with extensive signet ring cells, indicative of a Krukenberg tumor. CONCLUSION: This case report describes an uncommon example of a young pregnant woman without identifiable risk factors for gastric cancer who manifested a Krukenberg tumor. This incidental finding suggests that pregnancy obscured the cancer's clinical appearance. The rapid deterioration in the patient's condition corresponds to what is described in the literature. The limited information regarding this neoplasm in Mexico and the torpid evolution of the case highlight the importance of conducting additional studies to generate therapeutic interventions aimed at increasing overall survival.

Terapia de conversión en cáncer gástrico estadio IV: a propósito de un caso / Case Report of Conversion Therapy in Stage IV Gastric Cancer

Resumen Se reporta el caso de una paciente de 47 años, con diagnóstico inicial de un tumor de Krukenberg por una lesión anexial de 10 cm de diámetro y una lesión corporal gástrica de 3 cm. La biopsia mostró un adenocarcinoma pobremente diferenciado con células en anillo de sello. Una laparoscopia inicial mostró un índice de carcinomatosis peritoneal (ICP) de 24, por lo cual se le indica a la paciente quimioterapia con intención paliativa (cisplatino y capecitabina). Con mejoría clínica importante, respuesta adecuada y favorable a la quimioterapia, la paciente se remitió a una salpingo-ooforectomía bilateral. Continúa con quimioterapia evidenciándose mejoría de las imágenes tomográficas y una excelente respuesta clínica. Por este motivo, se decide en conjunto con la familia llevarla a cirugía. Se le practica una gastrectomía total con linfadenectomía D2 con intención curativa. La paciente recibe quimioterapia con capecitabina y cisplatino por 3 meses más, hasta cuando se evidencia compromiso ganglionar paraaórtico, por lo que es necesario reiniciar la quimioterapia con un nuevo esquema, entonces se le formula irinotecán. La paciente completa 22 meses desde el diagnóstico inicial, la condición clínica es muy buena y está asintomática.

Abstract We report the case of a 47-year-old patient initially diagnosed with a Krukenberg tumor, an adnexal lesion 10 cm in diameter and a 3 cm lesion in the gastric corpus. A biopsy showed a poorly differentiated adenocarcinoma with signet ring cells. Initial laparoscopy showed an index of peritoneal carcinomatosis of 24 which indicated chemotherapy with palliative intent (cisplatin and capecitabine). The patient improved significantly and underwent a total hysterectomy with salpingo-oophorectomy. Chemotherapy continued with excellent clinical response as evidenced in CT scans. Together with the patient's family, it was decided that she should undergo surgery. A total gastrectomy with D2 lymphadenectomy with curative intent was performed. The patient continued to receive capecitabine and cisplatin for three more months until para-aortic lymph node involvement was demonstrated and it became necessary to restart chemotherapy with a new scheme using iriniotecan. The patient has completed 22 months after the initial diagnosis in very good and clinical condition without symptoms.

Tumor de Krukenberg secundario a carcinoma de colon durante el embarazo / Krukenberg tumor secondary to carcinoma of the colon during pregnancy

El tumor de Krukenberg (TK) es un tumor metastásico en el ovario, y el carcinoma primario más frecuente es el de origen gástrico. Su incidencia es muy baja en la población general, y excepcional su asociación al embarazo. Se presenta el caso de una paciente de 17 años con diagnóstico de tumor de Krukenberg en las 20 semanas de gestación, como tumor primario se encontró un adenocarcinoma de colon(AU)

Krukenberg tumor (KT) is a metastatic tumor in the ovary, and the most common primary carcinoma is the gastric origin. Its incidence is very low in general population, and its association with pregnancy is exceptional. A 17 year-old patient is presented here with diagnosis of Krukenbergen tumor at the 20th weeks of gestation, as primary tumor a colon adenocarcinoma was found(AU)

Tumor de Krukenberg: presentación de un caso / Krukenberg tumor: report of a case

El tumor de Krukenberg representa del 1 al 2 por ciento del total de neoplasias ováricas, se considera que se diagnostica en alrededor del 30 por ciento de los cánceres metastáticos al ovario, se caracterizan por la presencia de células en anillo de sello y su origen más frecuente es aparato digestivo y mama. El pronóstico de una paciente con este tumor es extremadamente pobre. Se presenta un caso de una paciente femenina de 47 años que ingresó por dolores abdominales bajos y tumor abdominal palpable a la que se le realizó laparotomía con diagnóstico de tumor de ovario. El informe anatomopatológico arrojó un tumor de Krukenberg, confirmándose su origen en un adenocarcinoma de colon bien diferenciado(AU)

The Krukenberg tumor represents 1 to 2 percent of all ovarian cancers, its diagnosis is considered to be in approximately 30 percent of metastatic to the ovary cancers, and are characterized by the presence of cell-ring and its most common source is digestive tract and breast. The prognosis of a patient with this tumor is extremely poor. A case of a female patient aged 47 was admitted for lower abdominal pain and palpable abdominal tumor, she was underwent laparotomy with a diagnosis of ovarian tumor. The pathology report showed a Krukenberg tumor, confirming its origin in a well-differentiated adenocarcinoma colon

Metastatic Ovarian Tumor Masquerading as Atypical Pneumonia.

Krukenberg tumor is a malignancy in the ovary from a primary lesion in the gastrointestinal tract and a metastatic signet ring cell adenocarcinoma to the ovary. Stomach is the most common primary site, but other organs can serve as a primary site. The lymphatic system is the most likely route for metastasis. CA 125 levels can be used for screening for early detection of ovarian metastasis as well as for monitoring the course of disease. The prognosis of Krukenberg tumor is poor and no curative treatment is currently available.

Tumor de Krukenberg del ovario asociado a teratoma maduro / Krukenberg tumor of the ovary associated with mature teratoma

Se reporta un caso excepcional de tumor de Krukenberg ovárico bilateral asociado a teratoma maduro encontrado en una mujer de 54 años. La ecografía mostró al lado derecho tumor ovárico sólido de 55 mm y al lado izquierdo tumor quístico de 125 mm. Se realizó histerectomía total, salpingooforectomía bilateral, resección del epiplón mayor y muestras peritoneales. Al tercer día postcirugía, la paciente presentó signos de tromboembolismo pulmonar masivo y aunque recibió terapia anticoagulante falleció al quinto día postoperatorio. El estudio histológico mostró infiltración masiva de carcinoma de células en anillo positivas para citoqueratina en ambos ovarios. El ovario derecho mostró la forma sólida clásica del tumor de Krukenberg mientras que el ovario izquierdo correspondió a un quiste dermoide con infiltración tumoral de carcinoma de células en anillo en la pared.

An exceptional case of bilateral Krukenberg tumor of the ovary associated with mature teratoma presented in a 54 years old patient is reported. The ultrasound showed a 55 mm solid right ovarian tumor and a 125 mm left cystic ovarian tumor. Hysterectomy and bilateral salpingoophorectomy was performed including omental resection and peritoneal biopsies. Massive pulmonary embolism was detected in the third day after the surgery. Even anticoagulant therapy was established the patient died in the fifth postoperative day. The histological study revealed massive infiltration of signet ring cell carcinoma with positive expression for cytokeratin in both ovaries. The right ovary showed the classical solid form of the tumor. The left ovary was a dermoid cyst with signet ring cell carcinoma infiltrating the cystic wall.

Tumor de Krukenberg / Krukenberg Tumor

Introducción: el Krukenberg es un tumor metastático y representa del 1 por ciento al 2 por ciento de los tumores de ovario. El estómago es en el 70 por ciento de los casos la localización primaria más frecuente, seguidos por colon, apéndice y mama. El pronóstico es desfavorable y la evolución es rápida. Objetivo: describir un caso clínico de una paciente con tumor de Krukenberg. Presentación del caso: mujer de 53 años que consulta por sangramiento posmenopáusico a tipo manchas y dolor bajo vientre. Antecedentes personales de carcinoma gástrico, litiasis vesicular, nódulo de mama e hipertensión arterial. Se realizó estudio sonográfico ginecológico con marcadores para tumor de ovario positivos. Marcadores tumorales negativos. Resultados: hallazgo transoperatorio: se observó útero miomatoso y ambos ovarios multiloculados, superficie de revestimiento lisa de contenido mucinoso, con áreas sólidas de coloración heterogénea y consistencia renitente. Se realizó histerectomía con doble anexectomía. Conclusiones: el Krukenberg, tumor metastásico de ovario, es una entidad rara con mal pronóstico luego de su diagnóstico. Aún así la resección de dicha lesión metastásica es la primera recomendación la cual parece mejorar la sobrevida, seguida de terapia sistémica paliativa(AU)

Introduction: Krukenberg tumor is metastatic and it accounts for 1 percent to 2 percent of ovarian tumors. Stomach is the most common primary location in 70 percent of cases, followed by colon, appendix, and breast. The prognosis is poor and its evolution is rapid. Objective: to describe a case of a patient with Krukenberg tumor.Case presentation: a 53 year old woman was consulted due to menopausal bleeding in stains and lower abdomen pain. She had personal history of gastric carcinoma, gallstones, breast nodule and hypertension. Gynecologic sonographic study was performed with positive tumor markers for ovarian cancer and negative tumor markers.Results: intraoperative finding: fibroid uterus and both ovaries were loculate, smooth surface coating of mucinous content with solid areas of color and adverse heterogeneous consistency was observed. Hysterectomy with oophorectomy was performed.Conclusions: Krukenberg, metastatic ovarian tumor is a rare entity with poor prognosis after diagnosis. Still, resection of the metastatic lesion is the first recommendation which appears to improve survival, followed by palliative systemic therapy(AU)

Tumor de Krukenberg / Krukenberg tumor

Introducción: el Krukenberg es un tumor metastático y representa del 1 por ciento al 2 por ciento de los tumores de ovario. El estómago es en el 70 por ciento de los casos la localización primaria más frecuente, seguidos por colon, apéndice y mama. El pronóstico es desfavorable y la evolución es rápida. Objetivo: describir un caso clínico de una paciente con tumor de Krukenberg. Presentación del caso: mujer de 53 años que consulta por sangramiento posmenopáusico a tipo manchas y dolor bajo vientre. Antecedentes personales de carcinoma gástrico, litiasis vesicular, nódulo de mama e hipertensión arterial. Se realizó estudio sonográfico ginecológico con marcadores para tumor de ovario positivos. Marcadores tumorales negativos. Resultados: hallazgo transoperatorio: se observó útero miomatoso y ambos ovarios multiloculados, superficie de revestimiento lisa de contenido mucinoso, con áreas sólidas de coloración heterogénea y consistencia renitente. Se realizó histerectomía con doble anexectomía. Conclusiones: el Krukenberg, tumor metastásico de ovario, es una entidad rara con mal pronóstico luego de su diagnóstico. Aún así la resección de dicha lesión metastásica es la primera recomendación la cual parece mejorar la sobrevida, seguida de terapia sistémica paliativa.

Introduction: Krukenberg tumor is metastatic and it accounts for 1 percent to 2 percent of ovarian tumors. Stomach is the most common primary location in 70 percent of cases, followed by colon, appendix, and breast. The prognosis is poor and its evolution is rapid. Objective: to describe a case of a patient with Krukenberg tumor.Case presentation: a 53 year old woman was consulted due to menopausal bleeding in stains and lower abdomen pain. She had personal history of gastric carcinoma, gallstones, breast nodule and hypertension. Gynecologic sonographic study was performed with positive tumor markers for ovarian cancer and negative tumor markers.Results: intraoperative finding: fibroid uterus and both ovaries were loculate, smooth surface coating of mucinous content with solid areas of color and adverse heterogeneous consistency was observed. Hysterectomy with oophorectomy was performed.Conclusions: Krukenberg, metastatic ovarian tumor is a rare entity with poor prognosis after diagnosis. Still, resection of the metastatic lesion is the first recommendation which appears to improve survival, followed by palliative systemic therapy.

Fibroma ovárico con células estromales en anillo de sello: un tumor extremadamente infrecuente: diagnóstico diferencial del tumor de Krukenberg / Ovarian fibroma with stromal signet-ring cells: differential diagnosis of Krukenberg tumor

La presencia de "células en anillo de sello" en el tejido ovárico es el marcador histológico clásico del tumor de Krukenberg. Un adenocarcinoma metastásico altamente agresivo y de baja sobrevida. En cambio, los fibromas ováricos son tumores del estroma generalmente benignos. Presentamos un caso muy infrecuente de fibroma celular con presencia de células en anillo de sello y revisamos los criterios para el diagnóstico diferencial con el tumor de Krukenberg.

The presence of signet-ring cells in ovarian tissue is classically described as histological marker of Krukenberg tumor. It is highly aggressive metastatic adenocarcinoma with low survival. In contrast, ovarian fibroid is a stromal tumor usually benign. We present a very rare case of cellular fibroma with presence of signet-ring cells and we review the criteria for differential diagnosis of Krukenberg tumor.

Tumor de Krukemberg: presentación de un caso / Krukemberg tumor: a case report

Se presenta el caso clínico de una joven de 18 años de edad que ingresa en el Servicio de Oncología del Hospital Universitario Dr Celestino Hernández Robau, de Santa Clara, Villa Clara, con diagnóstico de tumor de ovario para tratamiento quirúrgico. El diagnóstico histopatológico fue de adenocarcinoma en anillo de sello (tumor de Krukenberg); el tumor primario se encontró en el colon. La frecuencia del tumor de Krukemberg es del 3-8 por ciento de los tumores ováricos, generalmente lo padecen mujeres entre la cuarta y la quinta décadas de la vida y la localización más frecuente del tumor primario es, en primer lugar, el estómago. Existen pocos estudios acerca de esta enfermedad a pesar de su mal pronóstico y rápida evolución(AU)

Friedrich Krukenberg, el del tumor de Krukenberg: a propósito de una serie de casos / Friedrich Krukenberg of Krukenberg's Tumor: Report of a series of cases

El tumor de Krukenberg (descrito por un médico alemán que tenía el mismo nombre) es un tumor de ovario que representa la metástasis de una tumoración primaria usualmente ubicada en el estómago. En este trabajo se realiza una breve reseña histórica y se presentan cinco casos manejados en nuestro servicio, con el fin de mostrar la complejidad de su diagnóstico, el abordaje terapéutico y el pésimo pronóstico que esta enfermedad tiene.

Krukenberg's tumor is an ovarian tumor first described by the German physician Friedrich Krukenberg. It is a metastasis of a primary tumor which is usually located in the stomach. This article presents a brief overview of the history of these tumors and a series of 5 cases which were handled in our service. The aim of this article is to demonstrate the complexity of this diagnosis, the therapeutic approach, and the pessimistic prognosis that this condition has.

Adenocarcinoma mucoproductor de colon con infiltración de estómago y metástasis ováricas (tumor de Krukenberg) / Colon mucoproducing adenocarcinoma with stomach infiltration and ovarian metastases (Krukenberg's tumor)

Se presenta una paciente femenina de 29 años, operada de urgencia por presentar un gran tumor que incluía cuerpo gástrico y colon trasverso, con una perforación gástrica. Se realizó una gastrectomía subtotal con colectomía trasversa en bloque que incluyó el epiplón mayor. El diagnóstico histológico fue adenocarcinoma túbulo papilar mucoproductor de origen colónico, que infiltra hasta la serosa y pared gástrica. Se realizó tratamiento adyuvante con poliquimioterapia. Diez meses después presenta un tumor en hipogastrio, que al tacto vaginal, correspondía a los órganos genitales, sospecha clínica que confirman el ultrasonido abdominal y la tomografía axial computarizada. El hallazgo transoperatorio fueron tumores voluminosos de ambos ovarios, y otro tumor que afectaba la unión rectosigmoide. Se realizó una histerectomía radical con ooforectomía bilateral y sigmoidectomía, se reseca la porción proximal del recto, y se cierra tipo Hartman. El diagnóstico histológico final fue metástasis en serosa uterina e intestinal, y en ambos ovarios de adenocarcinoma mucoproductor, túbulo papilar de intestino previamente diagnosticado (tumor de Krukenberg). Se complementó el tratamiento con poliquimioterapia adyuvante(AU)

This is the case of a woman aged 29 operated on of emergency due to a tumor involving gastric body and transverse colon with gastric perforation. A subtotal gastrectomy with block transverse colectomy including the greater omentum was carried out. The histological diagnosis was a mucoproducing papillary tubular adenocarcinoma of colonic origin infiltrating to serosa and gastric wall. An adjuvant treatment was applied with poly-chemotherapy. Ten months later appears a hypogastric tumor which at vaginal manual examination corresponding to genital organs, clinical suspicion confirmed by abdominal ultrasound and computerized axial tomography. The transoperative findings were bulky tumors of both ovaries and another tumor involving the rectosigmoid joint. A radical hysterectomy with bilateral oophorectomy and sigmoidectomy was carried out with resection of proximal rectal portion with type Hartman closure. The final histological diagnosis was a metastasis in uterine and intestinal serosa and in both ovaries a mucoproducing adenocarcinoma, previous papillary tubule was also diagnosed (Krukenberg's tumor). Treatment was applied using adjuvant poly-chemotherapy(AU)

Adenocarcinoma mucoproductor de colon con infiltración de estómago y metástasis ováricas (tumor de Krukenberg) / Colon mucoproducing adenocarcinoma with stomach infiltration and ovarian metastases (Krukenberg's tumor)

Se presenta una paciente femenina de 29 años, operada de urgencia por presentar un gran tumor que incluía cuerpo gástrico y colon trasverso, con una perforación gástrica. Se realizó una gastrectomía subtotal con colectomía trasversa en bloque que incluyó el epiplón mayor. El diagnóstico histológico fue adenocarcinoma túbulo papilar mucoproductor de origen colónico, que infiltra hasta la serosa y pared gástrica. Se realizó tratamiento adyuvante con poliquimioterapia. Diez meses después presenta un tumor en hipogastrio, que al tacto vaginal, correspondía a los órganos genitales, sospecha clínica que confirman el ultrasonido abdominal y la tomografía axial computarizada. El hallazgo transoperatorio fueron tumores voluminosos de ambos ovarios, y otro tumor que afectaba la unión rectosigmoide. Se realizó una histerectomía radical con ooforectomía bilateral y sigmoidectomía, se reseca la porción proximal del recto, y se cierra tipo Hartman. El diagnóstico histológico final fue metástasis en serosa uterina e intestinal, y en ambos ovarios de adenocarcinoma mucoproductor, túbulo papilar de intestino previamente diagnosticado (tumor de Krukenberg). Se complementó el tratamiento con poliquimioterapia adyuvante(AU)

This is the case of a woman aged 29 operated on of emergency due to a tumor involving gastric body and transverse colon with gastric perforation. A subtotal gastrectomy with block transverse colectomy including the greater omentum was carried out. The histological diagnosis was a mucoproducing papillary tubular adenocarcinoma of colonic origin infiltrating to serosa and gastric wall. An adjuvant treatment was applied with poly-chemotherapy. Ten months later appears a hypogastric tumor which at vaginal manual examination corresponding to genital organs, clinical suspicion confirmed by abdominal ultrasound and computerized axial tomography. The transoperative findings were bulky tumors of both ovaries and another tumor involving the rectosigmoid joint. A radical hysterectomy with bilateral oophorectomy and sigmoidectomy was carried out with resection of proximal rectal portion with type Hartman closure. The final histological diagnosis was a metastasis in uterine and intestinal serosa and in both ovaries a mucoproducing adenocarcinoma, previous papillary tubule was also diagnosed (Krukenberg's tumor). Treatment was applied using adjuvant poly-chemotherapy(AU)

Tumor de Krukenberg / Krunkenberg's tumor

El tumor de Krukenberg supone el 30-40 por ciento de los cánceres metastásicos al ovario y el 1-2 por ciento de todos los tumores malignos de ovario. En la actualidad, y pese a que el concepto de tumor de Krukenberg ha sido usado para referirse a todos los tumores metastásicos del ovario, se consideran como tal a los que tienen un origen digestivo. Su pronóstico es malo con raras supervivencias más allá del año. Se presenta un caso de una paciente femenina de 38 años de edad, que ingresa por ascitis moderada, anorexia y pérdida de peso, a la cual se le realizó una laparotomía con el posible diagnóstico de un proceso oncoproliferativo del ovario y el diagnóstico histopatológico arrojó un tumor de Krukenberg(AU)

Krukenberg's tumor accounts for 30-40 percent of ovarian metastatic cancer and for the 1-2 percent of all ovarian malignant tumors. Nowadays and in spite of the fact that the concept of Krukenberg' tumor has been used to refer to all ovarian metastatic tumors those with a digestive origin, its prognosis if bad with only a few survivals beyond one year. This is the case of a female patient aged 38 admitted due to a moderate ascites, anorexia and lose weight undergoes laparotomy with the possible diagnosis of a oncoproliferous ovarian process and the histopathological diagnosis showed a Krukenberg's tumor(AU)

Tumor de Krukenberg / Krunkenberg's tumor

El tumor de Krukenberg supone el 30-40 por ciento de los cánceres metastásicos al ovario y el 1-2 por ciento de todos los tumores malignos de ovario. En la actualidad, y pese a que el concepto de tumor de Krukenberg ha sido usado para referirse a todos los tumores metastásicos del ovario, se consideran como tal a los que tienen un origen digestivo. Su pronóstico es malo con raras supervivencias más allá del año. Se presenta un caso de una paciente femenina de 38 años de edad, que ingresa por ascitis moderada, anorexia y pérdida de peso, a la cual se le realizó una laparotomía con el posible diagnóstico de un proceso oncoproliferativo del ovario y el diagnóstico histopatológico arrojó un tumor de Krukenberg

Krukenberg's tumor accounts for 30-40 percent of ovarian metastatic cancer and for the 1-2 percent of all ovarian malignant tumors. Nowadays and in spite of the fact that the concept of Krukenberg' tumor has been used to refer to all ovarian metastatic tumors those with a digestive origin, its prognosis if bad with only a few survivals beyond one year. This is the case of a female patient aged 38 admitted due to a moderate ascites, anorexia and lose weight undergoes laparotomy with the possible diagnosis of a oncoproliferous ovarian process and the histopathological diagnosis showed a Krukenberg's tumor

Metástasis de carcinoma de estómago que simula cáncer primario de ovario: importancia de la biopsia por congelación / Metastasis of carcinoma of stomach cancer simulating primary ovarian tumor: importance of frozen biopsies

Objetivo: Importancia de la Bíopsia por congelación en el diagnóstico y manejo de las pacientes con tumores de ovario. Resultados: Comunicamos nueve casos de pacientes con tumores de ovario.El carcinoma primario se encontró durante la operación programada para resección del tumor de ovario.En estos casos durante el acto operatorio y por la biopsia por congelación se hizo diagnóstico de tumor de krukenberg y el carcinoma primario se encontró en el estómago. Conclusiones: El resultado del estudio de nueve pacientes con carcinoma gástrico que simulaba cancer primario de ovario, muestra la importancia de la biopsia por congelación y la comunicación con los médicos cirujanos durante el acto operatorio.

Objetive: The importance of frozen section in the Diagnosis and manegment of patients with ovarian tumors. Results: We report 9 cases of patients with ovary tumors. The primary carcinoma was found during an operation for the ovarian tumor. In these cases the diagnosis of krukenberg tumor was made intraoperatively by frozen section evaluation and the primary carcinoma were found in the stomach. Conclusions: The results of the study of 9 patients with metástasis from gastric carcinoma simulating primary carcinoma of the ovary show us the importance of frozen section and the comunication with the surgeon intraoperatively.