ABSTRACT
We report the case of a laboratory worker who received close medical follow-up after accidently inoculating her hand with a needle containing a Humera strain of Leishmania donovani amastigotes. She developed a leishmanoma and histologic evidence of local lymphatic dissemination before being treated. The spectrum of disease caused by L. donovani is discussed.
Subject(s)
Laboratory Infection/pathology , Leishmaniasis, Visceral/pathology , Adult , Antimony Sodium Gluconate/therapeutic use , Female , Humans , Leishmaniasis, Visceral/drug therapy , Lymph Nodes/pathologyABSTRACT
Klebsiella aerogenes was identified as the pathogen in an epizootic of single and multiple abscesses in the cervical, axillary and inguinal regions in laboratory rats. Involvement of the salivary glands in the inflammatory tissue in some cases produced interlobular and interacinar fibrosis resembling "fibroadenosis'. Similar lesions were reproduced with a strain of Klebsiella aerogenes isolated from a diseased rat. Oral carriage of the same strain was detected in the diseased rats, and in normal rats of the same stock. Lymphadenitis appears to have been the primary lesion.
Subject(s)
Klebsiella Infections/veterinary , Laboratory Infection/veterinary , Rats, Inbred Strains , Animals , Klebsiella Infections/pathology , Klebsiella pneumoniae , Laboratory Infection/pathology , Lymph Nodes/pathology , Rats , Rodent Diseases/pathology , Salivary Glands/pathologyABSTRACT
Pleural effusion disease (PED) is a generalized infection of laboratory rabbits caused by an unidentified agent, believed to be a virus. The histopathological response of 17 rabbits infected experimentally with this agent was studied. The light microscopical changes were minimal and the most consistent findings were alterations of the lymphoid tissue. Fatal infections were characterized by a uniform reduction of the splenic white pulp, focal degenerative changes of the thymus and lymph nodes and probably slight proliferative changes of the kidney glomeruli. In surviving animals there were transient myocardial and hepatic lesions and, after clinical recovery, proliferative changes in spleen, lymph nodes, interstitial lung tissue and probably kidney glomeruli. The results do not permit any conclusions to be drawn regarding the aetiology or the pathogenesis of PED infection.
