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1.
JAMA Otolaryngol Head Neck Surg ; 150(5): 368-377, 2024 May 01.
Article in English | MEDLINE | ID: mdl-38483372

ABSTRACT

Importance: Patients with induced laryngeal obstruction (ILO) present with a variety of behavioral health profiles. Identifying these profiles is crucial in that behavioral health conditions may affect treatment duration and outcomes. Objective: To characterize the prevalence of anxiety, depression, posttraumatic stress disorder (PTSD), and physical somatic symptoms in adult and pediatric patients with ILO and determine the factors associated with anxiety, depression, PTSD, and physical somatic symptoms in patients with ILO? Design, Setting, and Participants: This cross-sectional study included a nonprobability sample of 83 adult and 81 pediatric patients diagnosed with ILO at outpatient adult and pediatric otolaryngology clinics between 2021 and 2023. Exclusion criteria included a comorbid respiratory diagnosis other than asthma, head or neck cancer, or neurological impairments. Recruitment took place between September 2021 and March 2023. The analyses were run in January 2024. Main Outcome Measures: Patients were prospectively screened for anxiety, depression, PTSD, and somatic physical symptoms. In addition, any past behavioral health diagnoses were extracted from the medical record. Comorbidities, ILO symptoms triggers, and onset details were gathered from ILO evaluations. Adult patients completed the Screen for Adult Anxiety Related Disorders (SCAARED), depression (Patient Health Questionnaire [PHQ]-9), and somatic physical symptoms portions of the Patient Health Questionnaires (PHQ-15), and the PTSD Checklist for the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) (PCL-5). Pediatric patients completed the Screen for Child Anxiety Related Disorders (SCARED), depression (PHQ-9A) and somatic physical symptoms portions of the Patient Health Questionnaires for Adolescents (PHQ-15A), and the UCLA PTSD Reaction Index brief screeners. Results: Eighty-three adult patients participated in this study (mean [SD] age, 45.8 [14.3] years; 64 female, 19 male). Eighty-one pediatric patients participated (mean [SD] age, 13.83 [2.55] years; 67 female, 14 male). Adult and pediatric patients with ILO screened positive for elevated rates of anxiety (53 adults [63%]; 49 children [60%]), depression (27 adults [32%]; 25 children [30%]), and PTSD (29 adults [34%]; 13 children [16%]). Most of the patients with anxiety and depression symptoms were formally diagnosed prior to ILO evaluation, with rates of previously diagnosed anxiety, depression, and PTSD also above published norms. Adults were twice as likely as children to present with PTSD (odds ratio, 2.1; 95% CI, 0.05-4.48). Elevated rates of physical somatic symptoms were also evident, with 38 adults (45%) and 32 children (39%) scoring in the moderate to severe range. Conclusions and Relevance: This study found high rates of adult and pediatric patients with ILO screened positive for anxiety, depression, and PTSD symptoms. Future work should investigate how behavioral health and ILO treatments can best be coordinated to maximize treatment outcomes.


Subject(s)
Anxiety , Depression , Stress Disorders, Post-Traumatic , Humans , Male , Female , Cross-Sectional Studies , Stress Disorders, Post-Traumatic/epidemiology , Adult , Depression/epidemiology , Depression/etiology , Child , Middle Aged , Anxiety/epidemiology , Anxiety/etiology , Adolescent , Prevalence , Laryngostenosis/psychology , Laryngostenosis/epidemiology , Aged
2.
Am J Otolaryngol ; 42(5): 103013, 2021.
Article in English | MEDLINE | ID: mdl-33838356

ABSTRACT

OBJECTIVES: The current study seeks to identify the correlation between in-office spirometry data and voice-related quality of life in patients with subglottic stenosis (SGS). METHODS: Patients with SGS of any etiology were included when in-office spirometric data was available in addition to voice-related patient-reported outcomes (PROM) data in the form of the Voice Handicap Index-10 (VHI-10) and/or the Voice-Related Quality of Life (V-RQOL) survey. Overall survey scores and individual question responses were assessed for degree of correlation to spirometric data. RESULTS: Twenty-nine patients were included in the final analysis. Overall mean total VHI-10 scores totaled 7.15 (SD 9.11), while mean overall V-RQOL scores totaled 78.41 (SD 16.45). Both PEF and PIF rates correlated to total scores on the VHI and V-RQOL surveys. This correlation was stronger with PIF than with PEF, and with the V-RQOL than with the VHI. Questions related to breathlessness most closely correlated with spirometric data. CONCLUSION: Voice-related QOL is impacted in patients with SGS in a predictable way. Breathlessness while speaking may be more impactful than inability to produce speech in this population.


Subject(s)
Laryngostenosis/physiopathology , Patient Reported Outcome Measures , Quality of Life , Spirometry/methods , Voice , Adult , Aged , Dyspnea/etiology , Dyspnea/physiopathology , Dyspnea/psychology , Female , Humans , Laryngostenosis/complications , Laryngostenosis/diagnosis , Laryngostenosis/psychology , Male , Middle Aged , Speech , Surveys and Questionnaires
3.
Ear Nose Throat J ; 100(2_suppl): 122S-130S, 2021 Apr.
Article in English | MEDLINE | ID: mdl-33302743

ABSTRACT

OBJECTIVES: To determine the number of patients with idiopathic subglottic stenosis (iSGS) who have contracted coronavirus disease 2019 (COVID-19), the impact of the pandemic on patients' attitudes on seeking help and attending hospitals, as well as the delays in the offer of treatment from the local health care systems. METHODS: A 29-question survey was distributed to an international mailing list of patients with subglottic stenosis to assess the patient experience during the COVID-19 pandemic. RESULTS: A total of 543 patients with iSGS participated. Fewer than 1 in 10 patients with iSGS have experienced COVID-19 symptoms, which were predominantly mild to moderate, with only 2 hospitalizations. Most patients with iSGS (80.0%) have not been advised they are high risk for COVID-19, despite 36.5% of patients with iSGS being obese (body mass index of 30+). Delays to surgeries and in-office procedures have impacted 40.1% of patients currently receiving treatment, with 38.8% of patients increasingly struggling to breathe as a result. Anxiety and stress are increasing among patients, with 3 in 4 (75.2%) reporting they are anxious about travelling by public transport, contracting the virus in hospital and infecting loved ones (69.0% and 71.9%, respectively). Of greater concern is that 23.1% with increasing dyspnea state they are staying away from hospital despite their deteriorating health. CONCLUSIONS: The COVID-19 pandemic has had an impact on the physical and psychological health of patients with iSGS. Surgeons managing cases of laryngotracheal stenosis need to offer appropriate support and communication to these high risk patients. During the pandemic, this should include self-isolation if they are dyspneic or on treatments that may have reduced their immunity. In addition, they should offer safe clinical pathways to airway assessment and treatments, if they become necessary. To minimize unnecessary travel, much of the clinical monitoring can be carried out remotely, using telephone or video-based consultations, in conjunction with local health professionals.


Subject(s)
Anxiety/psychology , COVID-19/epidemiology , Dyspnea/physiopathology , Laryngostenosis/physiopathology , Stress, Psychological/psychology , Adult , Aged , Anxiety/epidemiology , COVID-19/diagnosis , COVID-19/physiopathology , COVID-19/therapy , Disease Management , Female , Hospitalization/statistics & numerical data , Humans , Laryngostenosis/epidemiology , Laryngostenosis/psychology , Laryngostenosis/therapy , Male , Middle Aged , Obesity/epidemiology , Patient Education as Topic , SARS-CoV-2 , Self-Help Groups , Stress, Psychological/epidemiology , Surveys and Questionnaires , Telemedicine , Time-to-Treatment
4.
Laryngoscope ; 131(2): 366-369, 2021 02.
Article in English | MEDLINE | ID: mdl-32902886

ABSTRACT

OBJECTIVES: Serial intralesional steroid injection (SILSI) is an emerging treatment for idiopathic subglottic stenosis (ISGS), providing improvement in both subjective symptoms and objective airflow parameters. Little is known about how this airway remodeling affects the voice. This project analyzes subjective voice changes after SILSI and correlates these with airflow parameters. METHODS: An ISGS database containing voice-related quality of life (V-RQOL) and spirometry (peak expiratory flow percentage [%PEF]) was retrospectively queried. Included were ISGS patients from 2009 to 2019 who had at least one SILSI treatment. Encounters without complete data were excluded. Differences between preprocedure and postprocedure metrics were calculated. Correlations and nonparametric bivariate analysis were performed. RESULTS: Six hundred and seventeen steroid injections were performed in 55 patients, with an average of 3.5 years of follow-up. The average V-RQOL for all patient encounters, both pre- and postprocedure, showed little subjective dysphonia (83.5 of 100, 95% confidence interval [CI] 81.6 to 85.4). Considering SILSI-only treatments, there were 143 encounters with full data; of these, V-RQOL improved in 70 (49.0%), did not change in 40 (28.0%), and worsened in 33 (23.0%). Average V-RQOL improvement for the entire cohort was 1.9 points (95% CI: 0.7 to 3.2), which was small but significant (P = .0003). Across all data, there was a weak but significant correlation between PEF% and V-RQOL (ρ = 0.22, P = .0043). CONCLUSION: SILSI was associated with improvement in subjective voice ratings in about half of patients, and the improvement correlated with improved airflow measurements. This research adds to the growing body of data regarding SILSI and suggests that further work on functional changes to the larynx with airway remodeling is imperative. LEVEL OF EVIDENCE: 4 Laryngoscope, 131:366-369, 2021.


Subject(s)
Dysphonia/drug therapy , Laryngostenosis/drug therapy , Quality of Life , Steroids/administration & dosage , Voice Quality/drug effects , Adolescent , Adult , Aged , Aged, 80 and over , Dysphonia/etiology , Dysphonia/psychology , Female , Humans , Injections, Intralesional , Laryngostenosis/complications , Laryngostenosis/psychology , Male , Middle Aged , Retrospective Studies , Severity of Illness Index , Treatment Outcome , Young Adult
5.
Laryngoscope ; 131(8): 1821-1827, 2021 08.
Article in English | MEDLINE | ID: mdl-32990358

ABSTRACT

OBJECTIVES: To determine the factors that shape utilization of social media-based online support communities (OSCs) and study the influence of these communities on medical decision-making in patients with Idiopathic Subglottic Stenosis (iSGS). STUDY DESIGN: Survey study. METHODS: A survey investigating OSC use was sent to the 1,056 members of the North American Airway Collaborative (NoAAC) iSGS1000 cohort in January 2018. Responses were merged with the existing NoAAC data set containing extensive demographic data, disease-specific history, and responses to validated patient-reported outcome measures. RESULTS: A total of 755 individuals with iSGS and mean age of 51.8 ± 11.6 years were included (99% female, 98% white, 63% college educated) and 58% were OSC users. Younger age, female gender, and college education were each associated with OSC use (P < .05). Users spent 2.5 ± 3.3 hours per week on the platforms. Time spent on OSC was not associated with total number of prior treatments. Higher disease anxiety (FoP-Q, R = 0.26, P < .001), lower social support (MOS, R = -0.12, P = .037), and lower level of shared-decision-making with the treating physician (SDM-Q9, R = -0.16, P = .007) were weakly associated with more hours spent engaging an OSC. OSC use influenced treatment and physician choice in 35% and 26% of users, respectively. Increased time spent on OSC use was associated with increased influence on patient medical decisions regarding treatment, surgery, and physician choice (P < .05). CONCLUSION: OSC engagement is common in patients with iSGS. Disease anxiety, social support, and relationship with the physician may influence OSC utilization. More OSC engagement weakly associated with greater OSC influence on patient medical decision-making. LEVEL OF EVIDENCE: NA. Laryngoscope, 131:1821-1827, 2021.


Subject(s)
Laryngostenosis/psychology , Patient Participation/psychology , Social Support , Tongue Diseases/psychology , Tongue/pathology , Adult , Constriction, Pathologic , Decision Making , Female , Humans , Laryngostenosis/pathology , Male , Middle Aged , Surveys and Questionnaires , Tongue Diseases/pathology
6.
Laryngoscope ; 131(2): 360-365, 2021 02.
Article in English | MEDLINE | ID: mdl-33026661

ABSTRACT

OBJECTIVES: To characterize the impact of subglottic stenosis (SGS) on voice-related quality of life (V-RQOL) and quantify the effect of treatment on voice outcomes. STUDY DESIGN: Case series. METHODS: Retrospective review of SGS patients treated from 1996 to 2018 at a single institution to assess for 1) V-RQOL association with individual patient cumulative treatment number and 2) V-RQOL correlation with treatment type, time between treatments, and degree of stenosis. Analysis included both parametric and nonparametric statistical comparison across treatment types and multivariable and univariate linear regression. RESULTS: Sixty-one patients, predominantly white (93%) and female (93%), were included. Etiology of SGS included idiopathic (61%), iatrogenic (16%), granulomatosis with polyangiitis (16%), and other (7%). The plurality of patients had four or more treatments (44%), with the remainder having one (28%), two (13%), or three treatments (15%). Analysis of change between pre- and postoperative V-RQOL scores was completed for 130 treatments. These included dilation with laser incision (52%), in-office injection (34%), dilation without division (8%), cricotracheal resection (1%), and all other treatment (8%). For every 10% improvement in airway caliber postoperatively, there was a 1.3-point improvement in calculated V-RQOL (r = 0.27, P = .02). After adjustment for treatment type, age, sex, and SGS etiology, this association held (beta = 1.5, P = .02). Change in V-RQOL was not associated with treatment type, treatment number, or time between treatments. CONCLUSION: Patients with subglottic stenosis who have greater degree of change in airway caliber experience greater improvement in V-RQOL scores following treatment. V-RQOL scores are not associated with treatment type or time between individual treatments. LEVEL OF EVIDENCE: 4 Laryngoscope, 131:360-365, 2021.


Subject(s)
Laryngostenosis/psychology , Postoperative Complications/psychology , Quality of Life , Voice Disorders/psychology , Voice Quality , Adult , Aged , Female , Humans , Laryngostenosis/physiopathology , Laryngostenosis/surgery , Male , Middle Aged , Postoperative Complications/etiology , Postoperative Complications/physiopathology , Postoperative Period , Retrospective Studies , Severity of Illness Index , Surveys and Questionnaires , Treatment Outcome , Voice Disorders/etiology , Voice Disorders/physiopathology
7.
Laryngoscope ; 130(4): 1000-1006, 2020 04.
Article in English | MEDLINE | ID: mdl-31355958

ABSTRACT

OBJECTIVES: The social determinants of health affect a wide range of health outcomes and risks. To date, there have been no studies evaluating the impact of social determinants of health on laryngotracheal stenosis (LTS). We sought to describe the social determinants in a cohort of LTS patients and explore their association with treatment outcome. METHODS: Subjects diagnosed with LTS undergoing surgical procedures between 2013 and 2018 were identified. Matched controls were identified from intensive care unit (ICU) patients who underwent intubation for greater than 24 hours. Medical comorbidities, stenosis characteristics, and patient demographics were abstracted from the clinical record. Tracheostomy at last follow-up was recorded from the medical record and phone calls. Socioeconomic data was obtained from the American Community Survey. RESULTS: One hundred twenty-two cases met inclusion criteria. Cases had significantly lower education compared to Tennessee (P = .009) but similar education rates as ICU controls. Cases had significantly higher body mass index (odds ratio [OR]: 1.04, P = .035), duration of intubation (OR: 1.21, P < .001), and tobacco use (OR: 1.21, P = .006) in adjusted analysis when compared to controls. Tracheostomy dependence within the case cohort was significantly associated with public insurance (OR: 1.33, P = .016) and chronic obstructive pulmonary disease (OR: 1.34, P = .018) in adjusted analysis. CONCLUSION: Intubation practices, medical comorbidities and social determinants of health may influence the development of LTS and tracheostomy dependence after treatment. Identification of at-risk populations in ICUs may allow for prevention of tracheostomy dependence through the use of early tracheostomy and specialized follow-up. LEVEL OF EVIDENCE: Level 3, retrospective review comparing cases and controls Laryngoscope, 130:1000-1006, 2020.


Subject(s)
Critical Care/methods , Laryngostenosis/psychology , Social Determinants of Health , Tracheal Stenosis/psychology , Adult , Aged , Aged, 80 and over , Female , Follow-Up Studies , Humans , Laryngoscopy/methods , Laryngostenosis/diagnosis , Male , Middle Aged , Retrospective Studies , Risk Factors , Time Factors , Tracheal Stenosis/diagnosis , Treatment Outcome , Young Adult
8.
Ann Otol Rhinol Laryngol ; 129(4): 361-368, 2020 Apr.
Article in English | MEDLINE | ID: mdl-31747777

ABSTRACT

OBJECTIVE: Office-based steroid injection has shown promise for idiopathic subglottic stenosis (iSGS). It is important to understand safety and patient-lived experience. We report patient experience related to airway restriction, voice, and side effects. METHODS: Sixteen patients (51 ± 14 years) with mild-moderate (20-50%) stenosis undergoing office-based transnasal steroid injections were included; fourteen had prior operations. Patients typically underwent three injections, 1 month apart, followed by transnasal tracheoscopy 1 month later to evaluate outcome; number of injections can vary based on disease severity and response. Outcomes were Dyspnea Index (DI), Modified Medical Research Council (MMRC) dyspnea scale, voice handicap index-10 (VHI-10), and degree of stenosis (estimated from procedural video). At each visit, patients were queried about post-injection airway restriction and side effects. Paired t-tests compared values at baseline versus follow-up tracheoscopy. RESULTS: DI decreased (t = 3.938, P = 0.0013), as did MMRC (t = 2.179, P = 0.0457). There was no change in VHI-10 (t = 1.354; P = 0.1957) scores. Airway stenosis decreased (t = 4.331; P = 0.0006); this was not correlated with change in DI (r = 0.267, P = 0.318). Side effects included airway restriction lasting <48 hours (n = 5), cough (n = 3), and nasal pain (n = 2). CONCLUSION: Steroid injections improved upper airway symptoms. Side effects were mild and transient. Improvement in DI did not correlate with percent stenosis.


Subject(s)
Dyspnea , Glucocorticoids/administration & dosage , Injections, Intralesional , Laryngoscopy/methods , Laryngostenosis , Voice Disorders , Adult , Ambulatory Care/methods , Disability Evaluation , Dyspnea/etiology , Dyspnea/therapy , Female , Humans , Injections, Intralesional/adverse effects , Injections, Intralesional/methods , Laryngostenosis/complications , Laryngostenosis/physiopathology , Laryngostenosis/psychology , Laryngostenosis/therapy , Male , Middle Aged , Severity of Illness Index , Treatment Outcome , Voice Disorders/diagnosis , Voice Disorders/etiology , Voice Disorders/therapy
9.
Ann Otol Rhinol Laryngol ; 128(4): 345-351, 2019 Apr.
Article in English | MEDLINE | ID: mdl-30638026

ABSTRACT

OBJECTIVE:: People with subglottic stenosis (SGS) may experience laryngeal symptoms that pose significant challenges to management. This study surveyed the use and effects of nebulized treatments on laryngeal symptoms in a large cohort of adults with SGS. METHODS:: A survey of nebulized treatment practices was distributed to an online international community of over 2000 members; 316 individuals (298 female, 1 male, 17 declined to specify; age 25+ years) completed the survey. RESULTS:: Nearly half (144) of participants had tried a nebulizer in the past. Among those, half currently used nebulized treatments; the majority used these treatments regularly and for greater than 1 year. The most frequently reported treatments included isotonic saline (0.9% Na+Cl-) or hypertonic saline (3% Na+Cl-). Symptoms improved by these treatments included thick mucus (69%), cough (57%), throat dryness (31%), stridor (28%), and voice (15%). The most frequently reported limitations to nebulizer use included time, noise, and portability. CONCLUSION:: Among those individuals with SGS who have tried nebulized treatments, nearly half experienced relief from secondary laryngeal symptoms. Additional efficacy research is needed, particularly with respect to treatment type and dosage. The results are encouraging given the adverse impact these laryngeal symptoms can have on activities of daily living and quality of life.


Subject(s)
Cough , Dysphonia , Dyspnea , Laryngostenosis , Nebulizers and Vaporizers , Quality of Life , Respiratory Therapy , Saline Solution, Hypertonic/therapeutic use , Activities of Daily Living , Adult , Aged , Cough/etiology , Cough/therapy , Dysphonia/etiology , Dysphonia/therapy , Dyspnea/etiology , Dyspnea/therapy , Female , Humans , Laryngostenosis/physiopathology , Laryngostenosis/psychology , Laryngostenosis/therapy , Male , Middle Aged , Patient Preference/statistics & numerical data , Respiratory Therapy/instrumentation , Respiratory Therapy/methods , Surveys and Questionnaires
10.
Ann Otol Rhinol Laryngol ; 128(4): 293-299, 2019 Apr.
Article in English | MEDLINE | ID: mdl-30607984

ABSTRACT

OBJECTIVE:: Idiopathic subglottic stenosis (iSGS) is a rare disease with few local resources for individuals to use. With the explosive growth of online social networking, platforms such as Facebook possess compelling potential to facilitate user-driven sharing of health information and peer support. This study was performed to better understand the content shared in a busy online community for individuals with iSGS. METHODS:: The largest online community (OC) for individuals with iSGS, Living With Idiopathic Subglottic Stenosis (LwiSGS), was examined. A thematic content analysis of the communications shared in February of 2018 was performed. A conventional qualitative analysis model was employed to analyze aggregated data. The data were then codified. RESULTS:: Analysis demonstrated that communications primarily encompassed three major thematic elements: (1) information sharing; (2) emotional support, expression, and experience sharing; and (3) community building. Positively toned posts grossly overshadowed negatively toned posts by almost a factor of 3. A significant portion of group members requested information from their peers, suggesting a high level of trust toward the resources provided in this group, even those involving a surgical procedure or medication. CONCLUSION:: LwiSGS is a forum for patients with a rare chronic condition to share informational resources, personal experiences, and emotional support, as well as a community with their peers. These data suggest that LwiSGS could be a powerful resource for individuals with iSGS to share information, personal experiences, or emotional support.


Subject(s)
Access to Information , Disease Management , Information Dissemination/methods , Internet , Laryngostenosis , Self-Help Groups , Emotions , Female , Global Health/trends , Humans , Laryngostenosis/epidemiology , Laryngostenosis/psychology , Male , Psychosocial Support Systems , Self-Help Groups/organization & administration , Self-Help Groups/trends
11.
J Voice ; 33(6): 880-893, 2019 Nov.
Article in English | MEDLINE | ID: mdl-30195411

ABSTRACT

INTRODUCTION: Athletes with exercise-induced laryngeal obstruction (EILO) (previously commonly referred to as paradoxical vocal fold motion disorder, or paradoxical vocal fold motion, among other terms) are often misdiagnosed, resulting in prolonged, and at times inappropriate, clinical management. The high prevalence of misdiagnosis is largely due to a lack of universal consensus of key clinical features indicating EILO and a dearth of validated quantitative approaches to accurately detect episodic laryngeal breathing disorders (ELBD) from other pathologies. Additionally, mechanisms underlying EILO clinical presentation are poorly understood, further confounding identification and management of the condition. Therefore, the objectives of this study were twofold. The first was to identify patient-centered perception of symptoms that could distinguish adolescent athletes with EILO from athletes without the condition, at baseline (rest) and during an exercise challenge (provocation), and to quantify symptom severities for use as preliminary diagnostic benchmarks. The second objective was to investigate the merit of one commonly proposed mechanism in the EILO literature-stress reactivity (temperament)-by comparing personality traits in athletes with and without EILO. METHODS: Twelve (12) athletes diagnosed with EILO and 14 healthy athletic volunteers without the condition were asked to rate the severity of their present symptoms using a 0-100 continuous visual analog scale. Participants then underwent an exercise challenge with simultaneous laryngoscopy and were asked to complete the same set of symptom severity ratings experienced during rigorous exercise. Finally, participants completed the Fear subscale on the early adolescent temperament questionnaire-revised (EATQ-R) to measure self-perceived levels of stress reactivity. RESULTS: There were significant group differences for inspiratory and expiratory dyspnea with exercise (P = 0.01). Symptoms of stridor (EILO: P = .01; control: P = .001) and throat tightness (EILO: P = .01, control: P = .01) were statistically different between rest and exercise in both groups. However, no group differences were found on these two parameters (P > .05). Other symptoms from the list of previously purported symptoms indicative of ELBD (e.g. cough, dysphonia) were infrequently reported in the exercise variant. Additionally, measurements of stress reactivity on the EATQ-R Fear subscale were similar between the two athletic groups. Interestingly, EATQ-R Fear Subscale scores for both groups were significantly higher compared to typical adolescents in the U.S. population (P < .001, respectively). DISCUSSION: Results suggest dyspnea severity, particularly when experienced during an exercise-induced ELBD (EILO) episode, is the most sensitive symptom parameter to distinguish individuals with EILO from those without the condition. These findings confirm previous literature describing episodic laryngeal breathing disorders in clinical cohorts. Results also showed symptoms of throat tightness and stridor is more prevalent during exercise, compared to rest. However, the level of their severity occurred variably across both groups of athletes and may point to a less robust indication of pathology. Finally, similarities to stress reactivity between the two athletic groups imply certain temperaments historically attributed to patients with EILO may instead better reflect temperaments in competitive young athletes, in general. CONCLUSION: Study findings highlight the importance of using normative comparisons in the study of episodic laryngeal breathing disorders to prevent overgeneralization of characteristics to clinical cohorts. Results also speak of the clinical utility of exercise challenge to improve specificity of EILO diagnosis.


Subject(s)
Athletes , Dyspnea/diagnosis , Exercise Test , Exercise , Laryngoscopy , Laryngostenosis/diagnosis , Surveys and Questionnaires , Vocal Cord Dysfunction/diagnosis , Adolescent , Case-Control Studies , Child , Dyspnea/etiology , Dyspnea/physiopathology , Dyspnea/psychology , Fear , Female , Humans , Laryngostenosis/etiology , Laryngostenosis/physiopathology , Laryngostenosis/psychology , Male , Predictive Value of Tests , Prospective Studies , Reproducibility of Results , Severity of Illness Index , Temperament , Vocal Cord Dysfunction/etiology , Vocal Cord Dysfunction/physiopathology , Vocal Cord Dysfunction/psychology
12.
Clin Otolaryngol ; 43(2): 645-651, 2018 04.
Article in English | MEDLINE | ID: mdl-29210179

ABSTRACT

OBJECTIVES: This study reports vocal function in a cross-section of children with subglottic stenosis. Each child had a history of laryngotracheal reconstruction and/or cricotracheal resection surgery. Vocal function was measured using laryngoscopy, acoustic analysis, perceptual evaluation and impact of voice on quality of life. DESIGN: All patients aged >5 years with history of laryngotracheal reconstruction and/or cricotracheal resection surgery at the Scottish National Complex Airways service were invited to participate. SETTING: Data were gathered in the Royal Hospital for Children in Glasgow in a single outpatient appointment. PARTICIPANTS: Twelve of 56 former patients (aged 5-27) provided a voice sample and eleven consented to awake laryngoscopy. All consented for detailed evaluation of their medical records. MAIN OUTCOME MEASURES: Acoustic analysis of fundamental frequency and pitch perturbation was conducted on sustained vowel [a]. Perceptual evaluation was conducted by 4 trained listeners on a series of spoken sentences. Impact on quality of life was measured using the paediatric voice-related quality of life questionnaire. Laryngeal function was descriptively evaluated. RESULTS: Four children had normal voice acoustically, perceptually and in relation to voice-related quality of life. One of these had vocal fold nodules unrelated to surgical history. Two other children had "near normal" vocal function, defined where most voice measurements fell within the normal range. CONCLUSIONS: Normal or "near normal" voice is a possible outcome for children who have had this surgery. Where there is an ongoing complex medical condition, voice outcome may be poorer.


Subject(s)
Laryngostenosis/surgery , Quality of Life , Voice Quality , Adolescent , Adult , Child , Child, Preschool , Cross-Sectional Studies , Female , Follow-Up Studies , Humans , Infant , Infant, Newborn , Laryngostenosis/complications , Laryngostenosis/psychology , Male , Recovery of Function , Treatment Outcome , Young Adult
13.
Ann Otol Rhinol Laryngol ; 124(9): 734-9, 2015 Sep.
Article in English | MEDLINE | ID: mdl-25910757

ABSTRACT

OBJECTIVES: To report and compare patients' experiences with acquired subglottic stenosis (AS) versus idiopathic subglottic and tracheal stenosis (ISTS). METHODS: A survey was made available to patients with AS and ISTS. Results were analyzed for inter- and intragroup differences using a 2-tailed t test. RESULTS: The study included 160 survey participants (AS n = 28; ISTS n = 132), with a predominance of female participants (82% AS, 98% ISTS). Acid reflux was the most prevalent comorbidity across groups (42%-43%). A significant difference in time to diagnosis was found between groups, with 32% of AS patients diagnosed within 3 months of symptom onset, compared to 2% with ISTS. A diagnosis delay greater than 18 months occurred for 58% of ISTS patients. There was no difference in treatment approach, with the most common treatment being balloon dilation, followed by laser dilation. Tracheal resection was performed in 36% of patients in both groups. Patient satisfaction with surgical outcomes was significantly higher after tracheal resection (76%) compared to other treatment modalities (39%). CONCLUSIONS: ISTS remains a diagnostic challenge as highlighted by the delay in diagnosis compared to AS. There appears to be no historical or symptomatic factors specific to ISTS. Additionally, patients report increased satisfaction and symptom resolution after tracheal resection.


Subject(s)
Dilatation/psychology , Laryngostenosis , Patient Satisfaction/statistics & numerical data , Quality of Life , Tracheal Stenosis , Tracheotomy/psychology , Adult , Age of Onset , Aged , Data Collection , Delayed Diagnosis/psychology , Delayed Diagnosis/statistics & numerical data , Dilatation/methods , Female , Humans , Laryngostenosis/diagnosis , Laryngostenosis/epidemiology , Laryngostenosis/etiology , Laryngostenosis/physiopathology , Laryngostenosis/psychology , Laryngostenosis/therapy , Male , Middle Aged , Sex Factors , Time-to-Treatment/statistics & numerical data , Tracheal Stenosis/diagnosis , Tracheal Stenosis/epidemiology , Tracheal Stenosis/etiology , Tracheal Stenosis/physiopathology , Tracheal Stenosis/psychology , Tracheal Stenosis/therapy , Tracheotomy/methods , Treatment Outcome
14.
Clin Otolaryngol ; 34(4): 343-8, 2009 Aug.
Article in English | MEDLINE | ID: mdl-19673982

ABSTRACT

OBJECTIVES: To validate the Clinical Chronic Obstructive Pulmonary Disease Questionnaire (CCQ), a patient-administered instrument developed for bronchopulmonary disease as a disease-specific psychophysical outcome measure for adult laryngotracheal stenosis. DESIGN: Prospective observational study. SETTINGS: Tertiary/National referral airway reconstruction centre. PARTICIPANTS: Thirty-three tracheostomy-free patients undergoing endoscopic laryngotracheoplasty. MAIN OUTCOME MEASURES: CCQ and the Medical Research Council (MRC) Dyspnoea scale, a previously validated but more limited scale, were administered to patients 2 weeks before surgery, preoperatively, and 2 weeks after endoscopic laryngotracheoplasty. Pulmonary function was assessed preoperatively. Internal consistency was assessed with Cronbach alpha statistics and test-retest reliability was determined using intraclass correlation. Correlations between CCQ and MRC scale, and pulmonary function were used to assess convergent and divergent validity respectively. Instrument responsiveness was assessed by correlating total and domain-specific CCQ scores with anatomical disease severity and post-treatment effect size. RESULTS: There were 12 males and 21 females. Mean age was 44 +/- 15 years. Cronbach alpha coefficient and intraclass correlation coefficient were 0.88 and 0.95 respectively. Total and domain-specific CCQ scores significantly correlated with the MRC scores (P < 0.001) and significant correlations between CCQ and peak expiratory flow rate and FEV(1) were identified (P < 0.03). There were statistically significant changes in total and domain-specific CCQ scores when different stenosis severities were compared. Clinical COPD Questionnaire scores also changed significantly and congruently following surgery (P < 0.05 in both cases). DISCUSSION: Clinical COPD Questionnaire is a valid and sensitive instrument for assessing symptom severity and levels of function and well-being in adult patients with laryngotracheal stenosis and can be used as a patient-centred disease-specific outcome measure for this condition.


Subject(s)
Laryngostenosis/psychology , Laryngostenosis/surgery , Patient Satisfaction , Postoperative Complications/psychology , Pulmonary Disease, Chronic Obstructive/psychology , Surveys and Questionnaires , Tracheal Stenosis/psychology , Tracheal Stenosis/surgery , Activities of Daily Living/psychology , Adolescent , Adult , Aged , Airway Obstruction/psychology , Depression/psychology , Dyspnea/psychology , Female , Humans , Lung Volume Measurements , Male , Middle Aged , Psychometrics/statistics & numerical data , Reproducibility of Results , Sick Role , Treatment Outcome , Young Adult
15.
Vestn Otorinolaringol ; (3): 20-3, 2002.
Article in Russian | MEDLINE | ID: mdl-12227023

ABSTRACT

45 children from 10 to 14 years of age with chronic laryngeal obstruction were examined psychologically. 29 of them had recurrent respiratory papillomatosis, 16 ones had cicatrical laryngostenosis. The majority of the examinees (65%) showed symptoms of posttraumatic stress syndrome (PTSS). The children develop PTSS one-two years after onset of laryngeal obstruction. Later, the children underwent persistent specific maladaptation personality disorders. Thus, children with recurrent laryngeal papillomatosis, especially with cicatrical laryngostenosis, should undergo psychological correction.


Subject(s)
Laryngostenosis/psychology , Stress Disorders, Post-Traumatic/etiology , Adolescent , Child , Female , Humans , Laryngeal Neoplasms/complications , Laryngostenosis/etiology , Male , Neoplasm Recurrence, Local , Papilloma/complications , Severity of Illness Index , Stress Disorders, Post-Traumatic/diagnosis , Stress Disorders, Post-Traumatic/epidemiology , Time Factors
16.
Int J Pediatr Otorhinolaryngol ; 32(2): 159-66, 1995 May.
Article in English | MEDLINE | ID: mdl-7657470

ABSTRACT

Physical illness in children is affected by a variety of factors unique to pediatrics. They include a child's developmental level, family environment and the presence of premorbid behavior patterns. Therefore, pediatric care requires special considerations pertaining to the patient-physician relationship and the potential for psychosocial dysfunction. Three case reports are presented to illustrate these concerns in treating children within the specialty of otolaryngology. Prompt identification of these factors and effective intervention in cases of psychosocial disturbance are challenging facets of the practice of pediatric otolaryngology.


Subject(s)
Otolaryngology/trends , Pediatrics , Physician-Patient Relations , Somatoform Disorders/etiology , Stress, Psychological/psychology , Adolescent , Child , Female , Gastrointestinal Diseases/psychology , Humans , Laryngostenosis/psychology , Male , Sinusitis/psychology , Stress, Psychological/diagnosis
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