Subject(s)
Leiomyoma/therapy , Leiomyomatosis/therapy , Uterine Neoplasms/therapy , Cost of Illness , Female , Humans , Infertility, Female/etiology , Infertility, Female/prevention & control , Leiomyoma/etiology , Leiomyoma/immunology , Leiomyoma/physiopathology , Leiomyomatosis/etiology , Leiomyomatosis/immunology , Leiomyomatosis/physiopathology , Quality of Life , Uterine Neoplasms/etiology , Uterine Neoplasms/immunology , Uterine Neoplasms/physiopathologySubject(s)
Leiomyoma/therapy , Leiomyomatosis/therapy , Models, Genetic , Models, Immunological , Therapies, Investigational , Uterine Neoplasms/therapy , Combined Modality Therapy/trends , Cost of Illness , Female , Humans , Leiomyoma/genetics , Leiomyoma/immunology , Leiomyoma/physiopathology , Leiomyomatosis/genetics , Leiomyomatosis/immunology , Leiomyomatosis/physiopathology , Therapies, Investigational/trends , Uterine Neoplasms/genetics , Uterine Neoplasms/immunology , Uterine Neoplasms/physiopathologySubject(s)
Activins/metabolism , Inhibin-beta Subunits/metabolism , Leiomyoma/metabolism , Leiomyomatosis/metabolism , Models, Biological , Myometrium/metabolism , Uterine Neoplasms/metabolism , Activin Receptors, Type I/chemistry , Activin Receptors, Type I/metabolism , Activin Receptors, Type II/chemistry , Activin Receptors, Type II/metabolism , Cell Transformation, Neoplastic , Female , Humans , Leiomyoma/immunology , Leiomyoma/pathology , Leiomyomatosis/immunology , Leiomyomatosis/pathology , Myometrium/immunology , Myometrium/pathology , Signal Transduction , Tumor Burden , Uterine Neoplasms/immunology , Uterine Neoplasms/pathologyABSTRACT
Benign metastasizing leiomyoma (BML) refers to benign pulmonary neoplasm associated with a previous or coincident history of uterine leiomyomata. We report the case of a 56-year-old postmenopausal woman with a 4-year history of multiple benign leiomyomatous lesions in bilateral lungs and the uterus. The tumor cells from the lungs and uterus were focally immunoreactive for HMB-45 antibody and progesterone receptor. Immunoreactivity to HMB-45 is well known in smooth muscle cells of hamartomatous neoplasms, such as angiomyolipoma and lymphangioleiomyomatosis, but has not been reported in BML previously. These features suggest a multifocal hamartomatous histogenesis rather than metastasis in the present case.
Subject(s)
Leiomyomatosis/diagnosis , Lung Neoplasms/diagnosis , Neoplasms, Second Primary/diagnosis , Antigens, Neoplasm/analysis , Female , Humans , Leiomyomatosis/chemistry , Leiomyomatosis/immunology , Lung Neoplasms/chemistry , Lung Neoplasms/immunology , Lung Neoplasms/secondary , Melanoma-Specific Antigens , Middle Aged , Neoplasm Proteins/analysis , Neoplasms, Second Primary/chemistry , Neoplasms, Second Primary/immunology , Receptors, Progesterone/analysis , Uterine Neoplasms/chemistry , Uterine Neoplasms/immunology , Uterine Neoplasms/pathologyABSTRACT
Oesophageal leiomyomatosis and idiopathic eosinophilic oesophagitis are both extremely rare. The former is a diffuse proliferation of smooth muscle in the muscularis propria, whilst the latter is an idiopathic inflammatory condition, thought to be associated with background atopy and characterized by an infiltrate of eosinophils throughout the full thickness of the oesophagus. However, two recent cases of oesophageal leiomyomatosis showed similar full thickness infiltration of the oesophageal wall by eosinophils and this inflammatory cell infiltrate was investigated in conjunction with one case of idiopathic eosinophilic oesophagitis. All three had a similar allergic profile characterized by CD45RO-positive primed T-lymphocytes, EG2-positive (i.e., activated) eosinophils, and tryptasepositive mast cells, together with gene expression for interleukin 4. Previous descriptions of leiomyomatosis describe an association with systemic mastocytosis and urticaria and the possibility that there is a common underlying allergic component to both disorders is raised.
