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1.
PLoS One ; 14(11): e0224351, 2019.
Article in English | MEDLINE | ID: mdl-31682606

ABSTRACT

To estimate the cost-effectiveness of available diagnosis alternatives for Mucosal Leishmaniasis (ML) in Colombian suspected patients. A simulation model of the disease's natural history was built with a decision tree and Markov models. The model´s parameters were identified by systematic review and validated by expert consensus. A bottom-up cost analysis to estimate the costs of diagnostic strategies and treatment per case was performed by reviewing 48 clinical records of patients diagnosed with ML. The diagnostic strategies compared were as follows: 1) no diagnosis; 2) parasite culture, biopsy, indirect immunofluorescence assay (IFA), and Montenegro skin test (MST) combined ; 3) parasite culture, biopsy, and IFA combined; 4) PCR-miniexon; and 5) PCR-kDNA. Three scenarios were modeled in patients with ML clinical suspicion, according to ML prevalence scenarios: high, medium and low. Adjusted sensitivity and specificity parameters of a combination of diagnostic tests were estimated with a discrete event simulation (DES) model. For each alternative, the costs and health outcomes were estimated. The time horizon was life expectancy, considering the average age at diagnosis of 31 years. Incremental cost-effectiveness ratios (ICERs) were calculated per Disability Life Year (DALY) avoided, and deterministic and probabilistic sensitivity analyses were performed. A threshold of willingness to pay (WTP) of three-time gross domestic product per capita (GDPpc) (US$ 15,795) and a discount rate of 3% was considered. The analysis perspective was the third payer (Health System). All costs were reported in American dollars as of 2015. PCR- kDNA was the cost-effective alternative in clinical suspicion levels: low, medium and high with ICERs of US$ 7,909.39, US$ 5,559.33 and US$ 4,458.92 per DALY avoided, respectively. ML diagnostic tests based on PCR are cost-effective strategies, regardless of the level of clinical suspicion. PCR-kDNA was the most cost-effective strategy in the competitive scenario with the parameters included in the present model.


Subject(s)
Cost-Benefit Analysis , Leishmania/isolation & purification , Leishmaniasis, Mucocutaneous/diagnosis , Models, Economic , Polymerase Chain Reaction/economics , Adult , Biopsy/economics , Colombia/epidemiology , Diagnostic Tests, Routine/economics , Health Care Costs/statistics & numerical data , Humans , Leishmaniasis, Mucocutaneous/economics , Leishmaniasis, Mucocutaneous/epidemiology , Leishmaniasis, Mucocutaneous/parasitology , Life Expectancy , Mucous Membrane/parasitology , Mucous Membrane/pathology , Prevalence , Quality-Adjusted Life Years
2.
Trop Med Int Health ; 22(12): 1569-1578, 2017 12.
Article in English | MEDLINE | ID: mdl-29078022

ABSTRACT

OBJECTIVE: To compare the cost-effectiveness of L-AmB with that of SbV and AmB-D, for the treatment of mucocutaneous leishmaniasis in a hospital in north-east Brazil. METHODS: We developed an economic model based on retrospective data of 73 hospitalised patients in 2006-2012, from hospital and public health system perspectives. RESULTS: In the economic model, 82.2% of patients who started treatment with L-AmB had completed it after 2 months, vs. 22.0% for the SbV and 19.9% for the AmB-D groups. After 12 months of follow-up, these proportions were 100% in the L-AmB, 77.4% in the AmB-D and 72.2% in the SbV group. Markov chain analyses showed that the group that started therapy with SbV had the lowest mean total cost (US$ 3782.38), followed by AmB-D (US$ 5211.27) and L-AmB (US$ 11 337.44). The incremental cost-effectiveness ratio for L-AmB was US$ 18 816.23 against SbV and US$ 24 504.65 against AmB-D. In the sensitivity analysis, the drug acquisition cost of L-AmB significantly influenced the results. CONCLUSIONS: In the treatment of mucocutaneous leishmaniasis, L-AmB is a cost-effective alternative to SbV and AmB-D owing to its higher effectiveness, safety and shorter course.


Subject(s)
Amphotericin B/economics , Antiprotozoal Agents/economics , Cost-Benefit Analysis , Drug Costs , Hospitalization , Leishmania braziliensis , Leishmaniasis, Mucocutaneous/economics , Adult , Aged , Amphotericin B/therapeutic use , Antiprotozoal Agents/therapeutic use , Brazil , Female , Humans , Leishmaniasis, Mucocutaneous/drug therapy , Male , Middle Aged , Models, Economic
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