ABSTRACT
The face has not been considered a common site of fixed drug eruption, and the authors lack dermatoscopic studies of this condition on the subject. The authors sought to characterize clinical and dermatoscopic features of 8 cases of an eruptive facial postinflammatory lentigo. The authors conducted a retrospective review of 8 cases with similar clinical and dermatoscopic findings seen from 2 medical centers in 2 countries during 2010-2014. A total of 8 patients (2 males and 6 females) with ages that ranged from 34 to 62 years (mean: 48) presented an abrupt onset of a single facial brown-pink macule, generally asymmetrical, with an average size of 1.9 cm. after ingestion of a nonsteroidal antiinflammatory drugs that lasted for several months. Dermatoscopy mainly showed a pseudonetwork or uniform areas of brown pigmentation, brown or blue-gray dots, red dots and/or telangiectatic vessels. In the epidermis, histopathology showed a mild hydropic degeneration and focal melanin hyperpigmentation. Melanin can be found freely in the dermis or laden in macrophages along with a mild perivascular mononuclear infiltrate. The authors describe eruptive facial postinflammatory lentigo as a new variant of a fixed drug eruption on the face.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Dermoscopy , Drug Eruptions/pathology , Facial Dermatoses/pathology , Lentigo/pathology , Skin/pathology , Adult , Biomarkers/analysis , Biopsy , Chile , Drug Eruptions/etiology , Drug Eruptions/metabolism , Facial Dermatoses/chemically induced , Facial Dermatoses/metabolism , Female , Humans , Hyperpigmentation/chemically induced , Hyperpigmentation/pathology , Lentigo/chemically induced , Lentigo/metabolism , Male , Melanins/analysis , Middle Aged , Predictive Value of Tests , Retrospective Studies , Risk Factors , Skin/chemistry , Skin/drug effects , SpainABSTRACT
This report describes four patients with chronic psoriasiform dermatitis of the palms and soles who developed pigmented macular lesions after localized photochemotherapy (PUVA) to these areas. These lesions had varied histopathologic presentations including lentigines, atypical melanocytic proliferation and a junction nevus suggesting a wide clinico pathologic spectrum in the PUVA-induced pigmented macules.
Subject(s)
Lentigo/chemically induced , Nevus, Pigmented/chemically induced , PUVA Therapy/adverse effects , Skin Neoplasms/chemically induced , Aged , Female , Humans , Male , Melanosis/chemically induced , Middle Aged , Psoriasis/drug therapyABSTRACT
This report describes four patients with chronic psoriasiform dermatitis of the palms and soles who developed pigmented macular lesions after localized photochemotherapy (PUVA) to these areas. These lesions had varied histopathologic presentations including lentigines, atypical melanocytic proliferation and a junction nevus suggesting a wide clinico pathologic spectrum in the PUVA-induced pigmented macules