Trends of leprosy and multibacillary infection in the state of Georgia since the early 1900s.

Few investigations to date have analyzed the epidemiology of Hansen's disease (leprosy) in the United States, and in particular, if birth location is related to multibacillary versus paucibacillary leprosy. We collected data on 123 patients diagnosed with leprosy in Georgia from the National Hansen's Disease Program from 1923-January 2018. A logistic regression model was built to examine the relationship between country of origin (U.S.-born or immigrant) and the type of leprosy. While the model showed no significant relationship between country of origin and type of leprosy, being Asian or Pacific Islander was associated with a higher odds of multibacillary disease (aOR = 5.71; 95% CI: 1.25-26.29). Furthermore, since the early 1900s, we found an increasing trend of leprosy reports in Georgia among both domestic born and immigrant residents, despite the overall decrease in cases in the United States during the same time period. More research is therefore necessary to further evaluate risk for multibacillary leprosy in certain populations and to create targeted interventions and prevention strategies.

Hanseníase paucibacilar: estudo retrospectivo da evolução clínica e laboratorial durante a poliquimioterapia dose fixa (PQT/OMS) / Paucibacillary leprosy: a retrospective study of clinical and laboratory during the fixed dose multidrug therapy (WHO / MDT)

Foram estudados retrospectivamente 185 pacientes hansenianos do Centro de Referência em Hanseníase do Ministério da Saúde da Fundação Oswaldo Cruz, classificados como paubacilares, que seguindo as recomendações da Organização Mundial de Saúde em 1982, receberam tratamento poliquimioterápico (PQT/OMS) com dose fixa...Através das correlações entre as variações podemos observar que não houve correlação entre o número de lesões cutâneas iniciais e o número de troncos neurais espessados (inicial) e qu eo número de troncos neurais espessados (inicial) não interferiu no grau de incapacidade inicial e final. A evolução clínica das lesões cutâneas e a evolução das lesões neurológicas não sofreram interferência das variáveis estudadas.