[Effect of a purine-free diet on the purine phosphoribosyltransferase activity of erythrocytes in patients with Lesch-Nyhan syndrome]. / Vliianie bespurinovoi diety na aktivnost' purinfosforiboziltransferazéritrotsitov u bol'nykh s sindromom Lesha-Nikhana.

Activity of purine phosphoribosyl transferases was studied in 11 patients with Lesch-Nyhan syndrome before and within 1 or 3 months after beginning of the purine-free diet treatment. The enzymatic activity tended to normalization within 1 month after the dietary treatment but the ratio of the enzymes activity was deteriorated within the subsequent 3 months of treatment. A positive clinical effect of the purine-free diet was noted.