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1.
Aust Vet J ; 98(3): 96-99, 2020 Mar.
Article in English | MEDLINE | ID: mdl-31919836

ABSTRACT

BACKGROUND: To the authors' knowledge, this is the first report of mast cell neoplasia in a koala (Phascolarctos cinereus). CASE REPORT: An adult female koala was presented for rapidly deteriorating health and death of a pouch young. Significant weight loss was apparent despite supplemental feeding; the abdomen was distended; and the koala was weak and mentally depressed. Haematology revealed a significant mastocytosis with a concurrent population of atypical mononuclear cells. The koala was euthanised and tissues were collected for histology. Bone marrow, lymph node, lung, stomach and spleen exhibited significant infiltration by mast cells. Atypical round cells consistent with those identified in the peripheral blood were also identified in the marrow. A diagnosis of systemic mastocytosis and probable mast cell leukaemia was made. Immunocytochemical and immunohistochemical staining was not able to further characterise the atypical cell population, and the mast cells exhibited only weak staining with CD117. CONCLUSION: The histological diagnosis, in this case, was systemic mastocytosis and myeloproliferative disease of uncertain origin. There was a dominant population of mast cells in the peripheral blood and marrow, and a population of circulating atypical mononuclear cells, appearing similar to mast cell leukaemia-acute myeloid leukaemia in humans.


Subject(s)
Leukemia, Mast-Cell/veterinary , Mastocytosis, Systemic/veterinary , Mastocytosis/veterinary , Phascolarctidae , Adult , Animals , Female , Humans , Mast Cells
3.
J Vet Med Sci ; 62(2): 187-90, 2000 Feb.
Article in English | MEDLINE | ID: mdl-10720189

ABSTRACT

An unusual case diagnosed as connective tissue-type mast cell leukemia with marked mastocyte infiltration into visceral organs in a seven-year-old female Curly-Coated retriever is presented. Acute circulatory collapse, emesis, diarrhea, abdominal enlargement, icterus, cyanosis, dyspnea, pulmonary edema, hepatomegary, ascites, and right ventricular enlargement were observed. Hematologic and biochemical examinations revealed mast cell leukemia, mature neutrophilia, monocytosis, thrombocytopenia, hemolytic hyperbilirubinemia, hyperhistaminemia, renal and hepatic injuries. Mast cells were distributed systemically, but predominantly in the diaphragm and liver with a large mass among the serosa of ileum, cecum and colon. Mast cells were stained intensely by both safranin and berberine sulfate.


Subject(s)
Dog Diseases/pathology , Leukemia, Mast-Cell/veterinary , Animals , Berberine/analysis , Dogs , Fatal Outcome , Female , Leukemia, Mast-Cell/pathology , Phenazines/analysis
4.
J Comp Pathol ; 119(1): 57-66, 1998 Jul.
Article in English | MEDLINE | ID: mdl-9717127

ABSTRACT

Bone-marrow changes in infectious diseases due to feline infectious peritonitis virus (FIPV), feline immunodeficiency virus (FIV), parvovirus (PV, canine and feline) and canine distemper virus (CDV), and in the lymphohaemopoietic neoplasias (LHNs) usually associated with feline leukaemia virus infection were studied in samples obtained from 204 cats and 82 dogs at necropsy. The study demonstrated (1) no changes, (2) non-specific reactive changes, and (3) disease-specific changes (similar to those occurring in extramedullary sites) in: 51.2, 48.8 and 9.7% of 41 cases of FIPV infection, respectively; 0, 100 and 0% of nine cases of FIV infection, respectively; 1.3, 0 and 92% of 75 cases of canine PV infection, respectively; 5.3, 3.9 and 84% of 76 cases of feline PV infection, respectively; 71.4, 28.6 and 0% of seven cases of CDV infection, respectively; and 35.9, 52.6 and 11.5% of 78 cases of LHN, respectively. The distribution of the disease-specific bone-marrow changes was either diffuse or focal; diffuse changes were frequently found in cases of feline and canine PV infection, and focal changes were found inconsistently in FIPV infections and feline LHN. To the extent that the bone marrow showed any changes in FIV and CDV infections, they were mostly reactive and not pathognomonic.


Subject(s)
Bone Marrow/pathology , Cat Diseases/pathology , Dog Diseases/pathology , Lymphoproliferative Disorders/veterinary , Virus Diseases/veterinary , Animals , Cats , Distemper/pathology , Dogs , Feline Infectious Peritonitis/pathology , Feline Panleukopenia/pathology , Female , Immunodeficiency Virus, Feline , Lentivirus Infections/pathology , Lentivirus Infections/veterinary , Leukemia, Mast-Cell/pathology , Leukemia, Mast-Cell/veterinary , Lymphoma/pathology , Lymphoma/veterinary , Lymphoproliferative Disorders/pathology , Male , Parvoviridae Infections/pathology , Parvoviridae Infections/veterinary , Parvovirus, Canine , Retrospective Studies , Virus Diseases/pathology
5.
J Comp Pathol ; 111(4): 453-8, 1994 Nov.
Article in English | MEDLINE | ID: mdl-7884062

ABSTRACT

Abdominal malignant mesothelioma was found in a 17-year-old, spayed female Japanese domestic cat with mast cell leukaemia. The mesothelioma was mainly located at the periphery of the pancreas, spleen and stomach, and showed metastases to the lung, an anterior mediastinal lymph node and lymph ducts in the tracheal mucosa. Micro-circulatory defects caused by the mast cell leukaemia may have been partly responsible for the distant metastases.


Subject(s)
Abdominal Neoplasms/veterinary , Cat Diseases , Leukemia, Mast-Cell/veterinary , Mesothelioma/veterinary , Neoplasms, Multiple Primary/veterinary , Abdominal Neoplasms/pathology , Animals , Cats , Fatal Outcome , Female , Immunohistochemistry , Leukemia, Mast-Cell/complications , Mesothelioma/secondary
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