Subject(s)
Leukemoid Reaction , Ovarian Neoplasms , Carcinoma, Ovarian Epithelial/pathology , Female , Fluorodeoxyglucose F18 , Humans , Leukemoid Reaction/diagnostic imaging , Leukemoid Reaction/etiology , Ovarian Neoplasms/diagnostic imaging , Ovarian Neoplasms/pathology , Positron Emission Tomography Computed TomographyABSTRACT
F-FDG PET/CT was performed on a 48-year-old woman with leukocytosis (white blood cell count 57.10 × 10/L, 84.0% neutrophils) and monoclonal gammopathy to investigate the possibility of reactive neutrophilia secondary to plasmacytoma. On the background of skeletal "superscan," the maximum intensity projection image of PET demonstrated the highest metabolic region in the left sacrum, which was confirmed as an osteolytic lesion by CT. Biopsy of the sacral lesion revealed a plasma cell myeloma, indicating the diagnosis of neutrophilic leukemoid reaction associated with multiple myeloma. The white blood cell counts dramatically dropped to the normal level after 1 cycle of chemotherapy for multiple myeloma.
Subject(s)
Fluorodeoxyglucose F18 , Leukemoid Reaction/complications , Leukemoid Reaction/diagnostic imaging , Multiple Myeloma/complications , Positron Emission Tomography Computed Tomography , Female , Humans , Middle Aged , Plasmacytoma/complications , Plasmacytoma/pathologySubject(s)
Down Syndrome , Leukemoid Reaction , Myelopoiesis/physiology , Ultrasonography, Prenatal , Adult , Down Syndrome/blood , Down Syndrome/diagnostic imaging , Down Syndrome/genetics , Female , Fetal Blood/cytology , GATA1 Transcription Factor/genetics , Hepatomegaly/diagnostic imaging , Humans , Infant, Newborn , Leukemoid Reaction/blood , Leukemoid Reaction/diagnostic imaging , Leukemoid Reaction/genetics , Pregnancy , Pregnancy Outcome , Prognosis , Splenomegaly/diagnostic imagingABSTRACT
An 18-year-old man with progressive headache and vomiting for 2 weeks had significantly elevated levels of WBC count, which kept on rising over time during in-hospital evaluation. Exhaustive examinations did not reveal infection or any other explanations of increased WBC count. Instead, brain MRI and FDG PET/CT identified a malignant lesion in the brain without abnormality elsewhere. The pathological examination revealed a rhabdoid meningioma. The level of the WBC counts returned to normal promptly after surgical resection of the tumor, which confirmed the diagnosis of paraneoplastic leukemoid reaction.
Subject(s)
Leukemoid Reaction/diagnostic imaging , Magnetic Resonance Imaging , Meningioma/diagnostic imaging , Positron-Emission Tomography , Rhabdoid Tumor/diagnostic imaging , Tomography, X-Ray Computed , Adolescent , Fluorodeoxyglucose F18 , Humans , Male , Multimodal Imaging , RadiopharmaceuticalsSubject(s)
Leukemoid Reaction/pathology , Neoplasms, Second Primary/pathology , Biomarkers, Tumor/analysis , Colonoscopy , Fatal Outcome , Female , Humans , Leukemoid Reaction/complications , Leukemoid Reaction/diagnostic imaging , Leukocyte Count , Liver/surgery , Middle Aged , Neoplasms, Second Primary/complications , Neoplasms, Second Primary/diagnostic imaging , Tomography, X-Ray Computed , UltrasonographyABSTRACT
A case of undifferentiated carcinoma of the nasopharynx presenting as a cervical mass associated with a paraneoplastic neutrophilic leukemoid reaction is reported. The diagnosis of undifferentiated nasopharyngeal carcinoma of the Regaud type was established by the presence of aggregates of epithelial neoplastic cells separated by areas of reactive lymphoid cells; the epithelial nature being confirmed by the positivity for epithelial markers (AE1/AE3, EMA). Serum IL-1a, GM-CSF and TNF alpha remained undetectable suggesting that these factors were not involved in the occurrence of the paraneoplastic leukemoid syndrome.
