1.
Proc Natl Acad Sci U S A
; 68(11): 2725-9, 1971 Nov.
Article
in English
| MEDLINE
| ID: mdl-5288250
ABSTRACT
In a patient with a severe attack of acute intermittent porphyria, hematin given intravenously caused marked diminution of serum delta-aminolevulinic acid and porphobilinogen. The decline of aminolevulinate was more rapid than that of porphobilinoge. After 2 days of hematin administration, about 5 days were required for delta-aminolevulinic acid, and 11 days for porphobilinogen to return to the concentrations that were detected before treatment. Urinary excretion of both compounds also decreased after hematin administration. Considerable amounts of porphobilinogen were also found in the cerebrospinal fluid of the patient.
Subject(s)
Heme/administration & dosage , Levulinic Acids/antagonists & inhibitors , Porphyrias/drug therapy , Porphyrins/antagonists & inhibitors , Pyrroles/antagonists & inhibitors , Adult , Amino Acids/antagonists & inhibitors , Amino Acids/blood , Amino Acids/cerebrospinal fluid , Amino Acids/urine , Female , Humans , Injections, Intravenous , Levulinic Acids/blood , Levulinic Acids/cerebrospinal fluid , Levulinic Acids/urine , Porphyrias/metabolism , Porphyrins/blood , Porphyrins/cerebrospinal fluid , Porphyrins/urine , Propionates/antagonists & inhibitors , Propionates/blood , Propionates/cerebrospinal fluid , Propionates/urine , Pyrroles/blood , Pyrroles/cerebrospinal fluid , Pyrroles/urine , Time Factors
2.
Mol Pharmacol
; 5(1): 10-20, 1969 Jan.
Article
in English
| MEDLINE
| ID: mdl-4392110
Subject(s)
Enzyme Induction/drug effects , Heme/biosynthesis , Microsomes, Liver/enzymology , Phenobarbital/pharmacology , Triazoles/pharmacology , Animals , Azo Compounds/pharmacology , Carbon Isotopes , Cytochromes/antagonists & inhibitors , Hydro-Lyases/antagonists & inhibitors , Iron Isotopes , Levulinic Acids/antagonists & inhibitors , Male , Microsomes, Liver/drug effects , Microsomes, Liver/metabolism , Morphinans/antagonists & inhibitors , Morphinans/metabolism , NADP/metabolism , Oxidoreductases/metabolism , Rats , Time Factors
3.
Biochem Soc Symp
; 28: 75-89, 1968.
Article
in English
| MEDLINE
| ID: mdl-5732380
