ABSTRACT
Because of an episode of abortion caused by a tetracycline-resistant Campylobacter jejuni, lincomycin was mixed into a barley pellet and fed to 3,000 range ewes at a dosage of 225 mg/ewe/day. After the second feeding, a number of ewes were anorectic and diarrheic, and 6 were dead. Necropsies revealed congestion and hemorrhage of the entire gastrointestinal tract. The feeding of the medicated pellets was discontinued immediately. Sick ewes were treated with antihistamines and corticosteroids, but they did not recover, and many died during the next several weeks. Lambs born within the first 7 days after the incident were alert and vigorous. Dams did not produce milk and many died during or after parturition. Later, however, lambs were born dead or weak, and abortions of autolyzed lambs began. Affected ewes examined 3 weeks later had salmonellosis and/or toxic tubular nephrosis associated with an oxalate-like crystal. The flock had been grazed on range infested with Halogeton glomeratus just before treatment with lincomycin, and it also had a history of Salmonella-related abortions. The deaths finally ceased after a month. Approximately 2,000 ewes and 3,200 lambs were lost, resulting in an economic loss of $550,000.
Subject(s)
Lincomycin/poisoning , Sheep Diseases/chemically induced , Abortion, Veterinary/etiology , Administration, Oral , Animal Feed , Animals , Campylobacter Infections/drug therapy , Campylobacter Infections/veterinary , Female , Lincomycin/administration & dosage , Pregnancy , Salmonella Infections, Animal/complications , Sheep , Sheep Diseases/drug therapy , Sheep Diseases/economicsSubject(s)
Animal Feed , Colitis/veterinary , Horse Diseases/chemically induced , Lincomycin/poisoning , Pregnancy Complications/veterinary , Animal Feed/analysis , Animals , Colitis/chemically induced , Female , Food Contamination , Horses , Lincomycin/analysis , Male , Pregnancy , Pregnancy Complications/chemically inducedABSTRACT
A 10-year old girl (34.5 kg) being treated at our clinic for osteomyelitis erroneously received an overdose of lincomycin. On a single day she was given 2 infusions containing 6 g of lincomycin each, which corresponds to a dose of 343 mg/kg of body weight. There was an interval of 10 h between infusions. Apart from fatigue and unpleasant taste sensation, she demonstrated no signs of intoxication. None of the laboratory parameters (GOT, GPT, gamma-GT, LDH, G-LDH, LAP, alkaline phosphatase and CK; furthermore, the concentrations of glucose, BUN, creatinine, uric acid and bilirubin) offered any evidence of toxic organ damage. Osteomyelitis in children demands extremely high doses of antibiotics. In view of this fact, the therapeutic range of a substance is of utmost clinical interest.
