Subject(s)
Linear IgA Bullous Dermatosis , Psoriasis , Skin Abnormalities , Skin Diseases , Humans , Linear IgA Bullous Dermatosis/chemically induced , Linear IgA Bullous Dermatosis/diagnosis , Pemetrexed/adverse effects , Nivolumab/adverse effects , Blister/chemically induced , Psoriasis/drug therapy , Immunoglobulin AABSTRACT
Linear IgA bullous dermatosis (LABD) is a rare autoimmune bullous disease characterized by linear IgA deposition along the skin basal membrane. In children, LABD classically presents with a "cluster of jewels" appearance, whereas in adults the classic presentation is itchy papules with tense vesicles and bullae on an erythematous base. We report the case of a 41-year-old woman with LABD that we suspect was induced by acute myeloid leukemia presenting with multiple vesicles and bullae that coalesced, forming the typical clinical manifestation of LABD and confirmed with histopathological and direct immunofluorescence. The patient was treated with a combination of oral and topical corticosteroids with excellent results.
Subject(s)
Linear IgA Bullous Dermatosis , Child , Female , Humans , Adult , Linear IgA Bullous Dermatosis/complications , Linear IgA Bullous Dermatosis/drug therapy , Linear IgA Bullous Dermatosis/chemically induced , Blister , Glucocorticoids/therapeutic useSubject(s)
Linear IgA Bullous Dermatosis , Stevens-Johnson Syndrome , Humans , Linear IgA Bullous Dermatosis/chemically induced , Linear IgA Bullous Dermatosis/diagnosis , Stevens-Johnson Syndrome/diagnosis , Stevens-Johnson Syndrome/etiology , Etanercept/adverse effects , Anti-Bacterial Agents/adverse effects , Vancomycin/adverse effects , Immunoglobulin ASubject(s)
COVID-19 , Linear IgA Bullous Dermatosis , Humans , Linear IgA Bullous Dermatosis/chemically induced , Linear IgA Bullous Dermatosis/diagnosis , Linear IgA Bullous Dermatosis/drug therapy , COVID-19 Vaccines/adverse effects , COVID-19/prevention & control , Vaccination/adverse effects , Immunoglobulin ASubject(s)
Linear IgA Bullous Dermatosis , Skin Diseases, Vesiculobullous , Cefixime/adverse effects , Humans , Immunoglobulin A , Linear IgA Bullous Dermatosis/chemically induced , Linear IgA Bullous Dermatosis/diagnosis , Renal Dialysis/adverse effects , Skin Diseases, Vesiculobullous/chemically induced , Skin Diseases, Vesiculobullous/diagnosisABSTRACT
A case of linear IgA bullous dermatosis developing 3 days after the second dose of Oxford AstraZeneca COVID-19 vaccine in an adult patient, suggesting a possible causal association. It is worth keeping in mind that COVID-19 vaccination could induce immune-mediated bullous disease in susceptible people.
Subject(s)
ChAdOx1 nCoV-19/adverse effects , Linear IgA Bullous Dermatosis/chemically induced , Humans , Male , Middle AgedSubject(s)
Exanthema , Linear IgA Bullous Dermatosis , Stevens-Johnson Syndrome , Anti-Bacterial Agents/adverse effects , Humans , Immunoglobulin A , Linear IgA Bullous Dermatosis/chemically induced , Linear IgA Bullous Dermatosis/diagnosis , Stevens-Johnson Syndrome/diagnosis , Stevens-Johnson Syndrome/etiology , Vancomycin/adverse effectsSubject(s)
Anti-Bacterial Agents/adverse effects , Linear IgA Bullous Dermatosis/chemically induced , Vancomycin/adverse effects , Aged , Basement Membrane/immunology , Fluorescent Antibody Technique , Humans , Immunoglobulin A/analysis , Linear IgA Bullous Dermatosis/pathology , Male , Myositis/drug therapy , Osteomyelitis/drug therapy , Skin/pathologySubject(s)
Amoxicillin-Potassium Clavulanate Combination , Linear IgA Bullous Dermatosis , Amoxicillin-Potassium Clavulanate Combination/adverse effects , Humans , Immunoglobulin A , Linear IgA Bullous Dermatosis/chemically induced , Linear IgA Bullous Dermatosis/diagnosis , Linear IgA Bullous Dermatosis/drug therapyABSTRACT
Linear IgA bullous dermatosis (LABD) is a rare autoimmune blistering disease that may be triggered by some diseases and medications. For the latter one, non-steroidal anti-inflammatory drugs (NSAIDs) have been identified as one of the potential causative agents to develop LABD. Here, a rare case of drug-induced LABD is introduced. A 13-month-old Iranian boy presented with a history of generalized blisters, displaying the classic "string of pearls" sign who was eventually diagnosed as a case of LABD. In his admission, he was diagnosed whit Mucocutaneous lymph node syndrome and treated with aspirin. Some features like appearing the characteristic lesions one week following the administration of aspirin, rapid clearance of lesions after the withdrawal of the drug, and reappearance of new lesions after readministration of aspirin were highly suggestive of aspirin-induced LABD. To establish the diagnosis, we used the "Naranjo probability score" which determined the probable causative role of aspirin. The diagnosis was confirmed by showing the positive IgA deposition in the basement membrane zone in a direct immunofluorescence study of the skin biopsy. The child was treated with dapsone with dramatical response to the drug.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Anti-Inflammatory Agents, Non-Steroidal/immunology , Aspirin/adverse effects , Aspirin/immunology , Immunoglobulin A/immunology , Linear IgA Bullous Dermatosis/chemically induced , Linear IgA Bullous Dermatosis/immunology , Humans , Infant , Iran , MaleABSTRACT
Linear IgA dermatosis (LAD) is a rare autoimmune disorder in children. A 9-year-old boy was presented with blisters on the intact skin (face, body, arms, hands, soles, perigenital and perianal area) after amoxicillin treatment. Systemic corticosteroids and dapsone treatment for 6 weeks was successful. Clinical and immunofluorescence examinations are most important for differentiation of LAD and other drug-induced bullous dermatoses. They enable an early introduction of proper therapy.
Subject(s)
Amoxicillin/adverse effects , Anti-Bacterial Agents/adverse effects , Linear IgA Bullous Dermatosis/chemically induced , Amoxicillin/administration & dosage , Anti-Bacterial Agents/administration & dosage , Child , Dapsone/administration & dosage , Glucocorticoids/administration & dosage , Humans , Linear IgA Bullous Dermatosis/diagnosis , Linear IgA Bullous Dermatosis/pathology , Male , Treatment OutcomeSubject(s)
Anti-Bacterial Agents/adverse effects , Linear IgA Bullous Dermatosis/chemically induced , Prosthesis-Related Infections/drug therapy , Skin Diseases, Vesiculobullous/chemically induced , Vancomycin/adverse effects , Aged , Female , Humans , Linear IgA Bullous Dermatosis/pathology , Skin Diseases, Vesiculobullous/pathology , Treatment OutcomeABSTRACT
Vancomycin is a widely used antibiotic in hemodialysis patients. The main complications include renal toxicity and skin lesions. Herein, we report the case of a 29-year-old hemodialysis patient who presented a bullous pruriginous dermatosis after vancomycin treatment. A skin biopsy revealed a linear IgA bullous dermatosis (LABD). This is a rare form of dermatosis and is either idiopathic or more likely vancomycin-induced. Similarities in the molecular structure of vancomycin and epidermal basement membrane glycoproteins could explain the auto-immune response. The overall prognosis after drug discontinuation and dermocorticoid treatment was good.
Subject(s)
Linear IgA Bullous Dermatosis/chemically induced , Renal Dialysis/adverse effects , Vancomycin/adverse effects , Adult , Humans , Male , Prognosis , Renal Dialysis/methodsABSTRACT
A 68-year-old woman was referred to the unit of dermatology for a large basal cell carcinoma on the chin. She was treated with imiquimod cream 5%, and 4 weeks after she developed isolated and grouped tense serum-filled vesicles and bullae on lips, nose, scalp, ankles and lumbar area, and then expanded to the whole body. Histological examination was consistent with a subepidermal bullous dermatosis. Moreover, direct immunofluorescence showed linear deposition of IgA at the basement membrane zone supporting the diagnosis of linear IgA bullous dermatosis (LABD). Dapsone 50 mg/day was administered, and the lesions gradually improved within some weeks, and no new lesions appeared. The temporal relationship between the application of the drug and the development of the disease indicates a role of this topical agent in triggering LABD.