ABSTRACT
A female infant with neonatal lupus erythematosus had scanty discoid lesions and concurrent lupus erythematosus profundus on the face. Depression of lupus erythematosus profundus lesions was still evident at 4 years of age.
Subject(s)
Facial Dermatoses/congenital , Lupus Erythematosus, Discoid/congenital , Panniculitis, Lupus Erythematosus/congenital , Facial Dermatoses/pathology , Female , Follow-Up Studies , Humans , Infant, Newborn , Lupus Erythematosus, Discoid/pathology , Panniculitis, Lupus Erythematosus/pathology , PrognosisABSTRACT
Neonatal lupus erythematosus (NLE) is a well established subset of Lupus erythematous (LE). Three chinese female neonates presented to our Skin Centre, from May 1990 to May 1991 with NLE. All had skin lesions without congenital heart block and systemic problems. Two had photosensitive annular erythematous lesions on scalp, urticarial lesions on body, and one with facial atrophy, with aplasia cutis congenita. The biopsies were non specific while one had C3 in vessel walls. The major serogical marker was anti La antibody/SSB in two babies and anti Ro antibody/SSA in one. Two mothers were known cases of LE and one, was undiagnosed. Two infants were treated with short term low dose prednisolone. The infants will require long term follow up with paediatricians, in view of the fact that they can develop SLE later. The diagnosis of NLE is emphasised in infants with facial lesions to avoid delay in diagnosis, and full work up in both infants and mother is necessary.
Subject(s)
Lupus Erythematosus, Discoid/ethnology , Antibodies, Antinuclear/blood , Biomarkers/blood , China/ethnology , Ectodermal Dysplasia/ethnology , Ectodermal Dysplasia/immunology , Female , Humans , Infant , Infant, Newborn , Lupus Erythematosus, Discoid/congenital , Lupus Erythematosus, Discoid/immunology , SingaporeSubject(s)
Lupus Erythematosus, Cutaneous/congenital , Lupus Erythematosus, Discoid/congenital , Child, Preschool , Female , Heart Block , Humans , Infant , Infant, Newborn , Lupus Erythematosus, Cutaneous/diagnosis , Lupus Erythematosus, Discoid/diagnosis , Male , Photosensitivity Disorders , Pregnancy , Pregnancy Complications/immunologyABSTRACT
Three patients had neonatal lupus erythematosus syndrome. All three infants were girls who presented with characteristic skin lesions but without evidence of congenital heart block. All three mothers were asymptomatic at the time of delivery and have remained so until the present time. All mothers were positive for anti-Ro/SSA antibodies, as were the infants prior to 6 months of age. Anti-La/SSB antibodies were not present in either the mothers or the infants. HLA typing revealed that two of the mothers were positive for B8 and DR3, while the third mother was positive for B8 and DR2. Two of the infants were positive for B8 and DR3, while the third infant was positive for DR2 only.
Subject(s)
Antibodies/analysis , Antigens/immunology , Autoantigens , Lupus Erythematosus, Discoid/immunology , RNA, Small Cytoplasmic , Ribonucleoproteins , Cicatrix/etiology , Female , HLA Antigens/analysis , Humans , Infant, Newborn , Lupus Erythematosus, Discoid/congenital , Lupus Erythematosus, Discoid/pathology , Lupus Erythematosus, Systemic/etiology , Risk , Time FactorsABSTRACT
A fetal congenital complete AV-block was detected in the 30th week of gestation. After close sonographic and cardiotocographic follow-up examinations premature labor occurred in the 37th week of gestation. The interpretation of the fetal heart rate pattern was difficult. The bradycardia was accompanied by late decelerations (dip II), only different from familiar hypoxia-patterns by the bradycardia. Caesarean section therefore was immediately done. A partial abruptio placentae was found as causing hypoxia. The child developed well after insertion of a temporary transvenous pacemaker. The AV-block is still persisting. At the age of three months the child fell ill of an acute cutaneous lupus erythematosus. The symptoms disappeared after unspecific treatment. Antinuclear antibodies pathognomonic for lupus erythematosus were traceable in the symptomless mother. There are other observations of motherly autoantibodies passing the placental barrier impairing the fetal heart conduction.
Subject(s)
Fetal Diseases/diagnosis , Heart Block/congenital , Adult , Autoantibodies/analysis , Bradycardia/congenital , Electrocardiography , Female , Fetal Growth Retardation/diagnosis , Fetal Monitoring , Gestational Age , Heart Block/diagnosis , Heart Block/immunology , Heart Rate , Humans , Infant, Newborn , Lupus Erythematosus, Discoid/congenital , Maternal-Fetal Exchange , Pacemaker, Artificial , PregnancyABSTRACT
A young woman with inactive discoid lupus erythematosus (LE) gave birth in three successive pregnancies to four male infants who showed cutaneous, and in one case cardiac, signs of neonatal LE. The mother had Ro and La antibodies although the anti-nuclear factor (ANF) was not consistently detectable. Three of the infants received phototherapy for neonatal jaundice. Maternal discoid LE may give rise to neonatal LE, and successive siblings can be affected.
Subject(s)
Lupus Erythematosus, Discoid/congenital , Adult , Antibodies, Antinuclear/analysis , Female , Heart Block/congenital , Heart Block/etiology , Humans , Infant, Newborn , Lupus Erythematosus, Discoid/genetics , Lupus Erythematosus, Discoid/immunology , Male , Maternal-Fetal Exchange , Pregnancy , Pregnancy Complications/immunologySubject(s)
Heart Block/congenital , Lupus Erythematosus, Discoid/congenital , Antibodies, Antinuclear/analysis , Female , Humans , Infant, Newborn , Lupus Erythematosus, Discoid/immunology , Lupus Erythematosus, Systemic/immunology , Male , Pregnancy , Pregnancy Complications/immunology , Syndrome , Time FactorsABSTRACT
A female infant, born to a 21-year-old mother with systemic lupus erythematosus, had cutaneous discoid lupus at birth. The lesions resolved spontaneously over the first few months and by the age of 1 year the infant's skin was normal. Other possible complications of this maternal disease are discussed and the need for caution in counselling mothers is recommended.
