ABSTRACT
A young woman presented with massive enlargement of a giant cervicomediastinal cystic hygroma, which communicated in part with the thoracic duct and was associated with generalized bony lymphangiomatosis. Modern imaging and sophisticated intraoperative physiologic monitoring made one-stage resection feasible. Tissue culture of explants of the hygroma yielded a primary endothelial cell line still surviving after 18 months, which, like the cyst-lining endothelium in the original resected specimen, reacted positively for Factor VIII-associated antigen. These findings, in conjunction with the histologic picture, support the notion that cystic hygroma represents an expanding proliferating endothelial growth process and not simply a sequestered lymphatic receptacle.
Subject(s)
Bone Neoplasms/secondary , Head and Neck Neoplasms/pathology , Lymphangioma/secondary , Mediastinal Neoplasms/pathology , Adult , Antigens/metabolism , Bone Neoplasms/pathology , Cell Line , Cell Transformation, Neoplastic/pathology , Culture Techniques , Endothelium/pathology , Factor VIII/immunology , Factor VIII/metabolism , Female , Humans , Lymphangioma/pathology , von Willebrand FactorABSTRACT
Computed tomographic (CT) evaluation of a rare thymic tumor in a child is described. The CT characteristics, pre- and postcontrast enhancement, are described and correlated with ultrasound and plain radiographic findings. Correlation is made between the CT results and the thymic lymphangioma with a subsequently identified abdominal lymphangioma.