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2.
World Neurosurg ; 99: 735-744, 2017 Mar.
Article in English | MEDLINE | ID: mdl-27476691

ABSTRACT

BACKGROUND: Hypophysitis is a rare disease entity mimicking a pituitary adenoma. Despite crucial disease involving a pituitary gland which is a main component of the hormonal axis, there have been minimal researches regarding the hypophysitis. In this study, we described the constellation of the preoperative findings including clinical, radiologic, and endocrinologic features, as well as postoperative outcomes of the hypophysitis. METHODS: The authors reviewed the data retrospectively of a total of 2814 patients who underwent microsurgery at our institution to treat a pituitary mass lesion. Among them, the patients proven as hypophysitis in histologic examination were enrolled, followed by stratification into tumor-associated hypophysitis and isolated hypophysitis depending on the existence of associated tumor lesion. As a result, a total 21 cases were enrolled consisting of the 13 cases of tumor-associated and the 8 cases of isolated hypophysitis. In this study, the isolated hypophysitis was focused on the analysis. All patients with isolated hypophysitis were evaluated the clinical, radiologic, and endocrinologic tests preoperatively. After microsurgery, all patients had a minimum follow up of 6 months (6∼72 months). The clinical symptoms, endocrinologic tests, and brain MRI were checked at every 6 months during first 2 year, since then, at every 12 months. RESULTS: Among 2814 cases of pituitary mass lesion underwent microsurgery, the hypophysitis were found 21 cases (0.74 %). The 13 cases were the tumor-associated hypophysitis, consisting of rathke's cleft cyst (7 cases), craniopharyngioma (3 cases), pituitary adenoma (2 cases), and germinoma (1 case). The 8 cases were the isolated hypophysitis including lymphocytic (4 cases), granulomatous (3 cases), and IgG4-related (1 case) hypophysitis. The patients presented a wide range of clinical symptoms from general weakness to panhypopituitarism. In addition, the most remarkable radiologic features of the isolated hypophysitis were infundibular thickening and the low signal intensity in T1WI and T2WI. All 8 patients with isolated hypophysitis presented endocrinologic deficiency with various extent in a preoperative biochemistry. After surgery, the hormonal status were not changed in 4 patients (50%), however, aggravated in 4 patients (50%). The 3 patients (37.5%) complained visual field defects in preoperative ophthalmologic test, but improved all after surgery. CONCLUSION: In this study, the preoperative clinical manifestations, radiologic and endocrinologic features of hypophysitis were described comprehensively. In addition, we also revealed the long-term outcomes of hypophysitis in the aspect of visual function and endocrinologic outcomes. Preexisting visual field defects were improved in all patients (3 cases). However, all patients presented endocrinologic deficiency in preoperative biochemistry, among them, the 4 patients (50 %) were unchanged and the 4 patients (50 %) were exacerbated after surgery. In conclusion, the visual outcomes were satisfactory, however, the endocrinologic outcomes were vice versa, because the preoperative endocrinologic deterioration was unchanged or even aggravated after surgery in some cases.


Subject(s)
Adenoma/diagnosis , Central Nervous System Cysts/diagnosis , Craniopharyngioma/diagnosis , Germinoma/diagnosis , Hypophysitis/diagnosis , Hypopituitarism/diagnosis , Pituitary Neoplasms/diagnosis , Adenoma/complications , Adenoma/surgery , Adolescent , Adult , Aged , Autoimmune Hypophysitis/diagnosis , Autoimmune Hypophysitis/surgery , Case-Control Studies , Central Nervous System Cysts/complications , Central Nervous System Cysts/surgery , Craniopharyngioma/complications , Craniopharyngioma/surgery , Diagnosis, Differential , Female , Germinoma/complications , Germinoma/surgery , Granuloma/diagnosis , Granuloma/surgery , Humans , Hypophysitis/etiology , Hypophysitis/surgery , Hypopituitarism/etiology , Lymphocytosis/diagnosis , Lymphocytosis/surgery , Male , Microsurgery , Middle Aged , Neurosurgical Procedures , Pituitary Neoplasms/complications , Pituitary Neoplasms/surgery , Retrospective Studies , Young Adult
6.
Am J Surg Pathol ; 37(7): 1085-90, 2013 Jul.
Article in English | MEDLINE | ID: mdl-23715167

ABSTRACT

Persistent polyclonal B-cell lymphocytosis is a rare, benign lymphoproliferative disorder characterized by a stable, polyclonal CD19-positive CD5-negative lymphocytosis, the presence of binucleated lymphocytes in peripheral blood, and a polyclonal increase in serum immunoglobulin-M that may occasionally be accompanied by splenomegaly. Histopathologic diagnosis of these splenectomy specimens is difficult because of the massive spleen infiltration and the rarity of the descriptions of this condition. We describe the histopathologic findings from 2 splenectomy specimens. These included a partially preserved architecture with infiltration of the red pulp by small lymphocytes and partial replacement of the white pulp. Suggestions for identifying the disorder are made.


Subject(s)
Lymphocytosis/pathology , Spleen/pathology , Splenomegaly/pathology , Adult , Antigens, CD19/metabolism , Clone Cells , Female , Humans , Immunoglobulin M/blood , Lymphocyte Count , Lymphocytes/pathology , Lymphocytosis/complications , Lymphocytosis/surgery , Middle Aged , Spleen/surgery , Splenomegaly/complications
7.
Am J Cardiol ; 112(3): 405-10, 2013 Aug 01.
Article in English | MEDLINE | ID: mdl-23623331

ABSTRACT

Heart transplantation (HT) for myocarditis has been controversial because of earlier reports of a poor prognosis after the procedure. We sought to determine whether lymphocytic myocarditis (LM) at the time of HT affects cardiac allograft rejection and survival after HT compared with other patients without LM in the current era of HT. We retrospectively reviewed 759 consecutive patients who underwent de novo HT at Columbia University Medical Center between 2000 and 2010 and compared prognosis after HT of the patients with pathologically proven LM in their explanted hearts with that of age- and gender-matched patients with idiopathic dilated cardiomyopathy (IDC group; n = 96) and with ischemic cardiomyopathy (IC group; n = 64). Thirty-two patients (4.2%) had LM in the explanted hearts pathologically. Among the 3 groups, no statistically significant difference was observed in the number of biopsy-diagnosed acute cellular rejection (ACR; International Society for Heart & Lung Transportation grade ≥2R) events during the first year after HT. In contrast, the frequency of biopsy-diagnosed ACR in subsequent years was greater in the LM group (n = 8, 3.8%) than in IC group (n = 3, 0.5%, p = 0.006), although no different from that of patients with IDC. The frequency of antibody-mediated rejection and posttransplant survival did not differ among the 3 groups. In conclusion, patients with pre-HT LM have an increased frequency of late ACR after HT compared with patients with IC. Nevertheless, survival of LM patients after HT is comparable to that of patients transplanted for IDC or IC.


Subject(s)
Graft Rejection/mortality , Heart Transplantation , Lymphocytosis/surgery , Myocarditis/surgery , Postoperative Complications/mortality , Adult , Biopsy , Cardiomyopathy, Dilated/mortality , Cardiomyopathy, Dilated/pathology , Cardiomyopathy, Dilated/surgery , Endocardium/pathology , Female , Follow-Up Studies , Graft Rejection/pathology , Heart Transplantation/pathology , Hospitals, University , Humans , Lymphocytosis/mortality , Lymphocytosis/pathology , Male , Middle Aged , Myocardial Ischemia/mortality , Myocardial Ischemia/pathology , Myocardial Ischemia/surgery , Myocarditis/mortality , Myocarditis/pathology , Myocardium/pathology , New York City , Postoperative Complications/pathology , Prognosis , Survival Rate
8.
Diagn Pathol ; 7: 107, 2012 Aug 19.
Article in English | MEDLINE | ID: mdl-22901769

ABSTRACT

Persistent polyclonal B-cell lymphocytosis (PPBL) is rare and intriguing hematological disorder predominantly reported in young to middle- aged smoking women. It is characterized by persistent moderate polyclonal B-cell lymphocytosis with circulating hallmark binucleated lymphocytes and elevated polyclonal serum IgM. Most patients have benign clinical course on long-term follow-up. Some pathologic features of PPBL may resemble malignant lymphoma, including morphology as well as frequent cytogenetic and molecular abnormalities. Significant symptomatic splenomegaly requiring splenectomy is very unusual for this disorder; therefore there is a lack of descriptions of the morphologic features of the spleen in the literature. We present here one of the first detailed descriptions of the morphologic and immunohistochemical features of the spleen from a young female with PPBL who developed massive splenomegaly during 6-year follow up. Splenectomy was performed for symptomatic relief and suspicion of malignant process. The morphological and immunohistochemical features of the spleen closely mimicked involvement by B-cell lymphoma, however there was no monotypic surface light chain restriction seen by flow cytometry and no clonal rearrangement of IgH gene was detected by molecular analysis. Evaluating a splenectomy sample in cases like this may present a diagnostic challenge to pathologists. Therefore, correlation with B cell clonality studies (by flow cytometry and molecular analysis), clinical findings and peripheral blood morphology searching for characteristic binucleated lymphocytes is essential to avoid misdiagnosing this benign process as B-cell lymphoma. We also present here a literature review on pathogenesis of PPBL. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/5329558967545656.


Subject(s)
Lymphocytosis/immunology , Lymphocytosis/pathology , Lymphoma, B-Cell/immunology , Lymphoma, B-Cell/pathology , Spleen/immunology , Spleen/pathology , Adult , Biomarkers/analysis , Biopsy , Diagnosis, Differential , Female , Flow Cytometry , Gene Rearrangement, B-Lymphocyte, Heavy Chain , Genes, Immunoglobulin Heavy Chain , Humans , Immunohistochemistry , Immunophenotyping/methods , Lymphocytosis/complications , Lymphocytosis/genetics , Lymphocytosis/surgery , Lymphoma, B-Cell/genetics , Predictive Value of Tests , Spleen/surgery , Splenectomy , Splenomegaly/immunology , Splenomegaly/pathology , Treatment Outcome
9.
Histopathology ; 55(6): 660-4, 2009 Dec.
Article in English | MEDLINE | ID: mdl-20002767

ABSTRACT

AIMS: Intravascular lymphocytosis (IVL) in appendectomy specimens is a fairly common phenomenon but has not been described and studied in detail. The aim was to describe the IVL phenomenon in appendiceal specimens removed for appendicitis that can mimic chronic lymphocytic leukaemia and to investigate factors that could contribute to the development of IVL. METHODS AND RESULTS: The clinicopathology of 100 appendectomy cases and the appendices from 20 right hemicolectomy cases were reviewed. The IVL phenomenon was more commonly seen in laparoscopic appendectomy specimens [Fisher's exact 0.011, odds ratio (OR) 3.14] and in patients <38 years old (Fisher's exact 0.012, OR 3.01). CONCLUSIONS: Surgical manipulation and the patient's innate immunity are contributary factors to the development of the IVL phenomenon. Pathologists should be aware of this histological artefact in order to prevent overdiagnosis of intravascular lymphoid neoplasia.


Subject(s)
Appendicitis/diagnosis , Appendix/pathology , Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis , Lymphocytosis/diagnosis , Adolescent , Adult , Aged , Aged, 80 and over , Antigens, CD/metabolism , Appendectomy , Appendicitis/complications , Appendicitis/surgery , Diagnosis, Differential , Female , Humans , Immunohistochemistry , Lymphocytosis/complications , Lymphocytosis/surgery , Male , Medical Records , Middle Aged
10.
Br J Haematol ; 144(5): 726-31, 2009 Mar.
Article in English | MEDLINE | ID: mdl-19133977

ABSTRACT

Five cases of persistent polyclonal B-cell lymphocytosis (PPBL) with progressive splenomegaly are reported; three were splenectomized. BCL2/IGH rearrangements were found in three cases; HLA-DRB1*07 in all. Bone marrow (BM) trephines showed a moderate lymphoid infiltrate with intrasinusoidal distribution resembling a splenic marginal-zone lymphoma. Splenic white pulp revealed an enlargement of the marginal-zone area; red pulp was infiltrated by the same lymphocytes engulfing the sinuses. Splenic and BM B-lymphocytes were CD79a(+)/CD20(+)/IgM(+)/IgD(+)/bcl-2(+)/CD27(+)/DBA.44(-)/CD31(-) and polyclonal by immunophenotype/polymerase chain reaction. PPBL features an expansion of splenic marginal-zone B-lymphocytes, which infiltrate BM sinusoids and circulate in the blood with no evidence of clonality, even in cases with progressive splenomegaly.


Subject(s)
B-Lymphocytes/immunology , Lymphocytosis/immunology , Smoking/immunology , Spleen/immunology , Splenomegaly/immunology , Adolescent , Adult , Bone Marrow/immunology , Female , Follow-Up Studies , Gene Rearrangement , HLA-DR Antigens/analysis , HLA-DRB1 Chains , Humans , Immunoglobulin Heavy Chains/genetics , Immunoglobulin Heavy Chains/immunology , Immunophenotyping , Lymphocyte Count , Lymphocytosis/surgery , Male , Polymerase Chain Reaction , Proto-Oncogene Proteins c-bcl-2/genetics , Proto-Oncogene Proteins c-bcl-2/immunology , Splenectomy , Young Adult
12.
Klin Monbl Augenheilkd ; 223(3): 243-6, 2006 Mar.
Article in German | MEDLINE | ID: mdl-16552658

ABSTRACT

BACKGROUND: Pseudotumors of the orbit comprise a group of idiopathic inflammatory processes and are, except for endocrine orbitopathy, the most common reason for exophthalmos in adults. Orbital pseudotumors, also called idiopathic orbital inflammatory syndrome (IOIS), can be determined from orbital involvement in systemic fibrosing diseases. Finding the correct diagnosis can be challenging. Due to the topographic relations of the orbit to neighbouring structures, a multidisciplinary cooperation is highly recommended. CASE REPORT: We report a case of a 42-year-old woman with unilateral exophthalmos. Additionally we found impaired motility of the affected bulbus, ptosis and reduction of visual acuity. Orbital MR imaging demonstrated dense fibrotic masses filling the whole orbita including the extraocular muscles as well as the optic nerve. Tissue specimens were extracted while performing orbital decompression via a lateral orbitotomy. Histological examination revealed a lymphatic infiltration and fibrotically destroyed tissue containing the lacrimal gland. After surgical decompression, oral steroid therapy and immunotherapy, a recovery of the visual loss could be seen. CONCLUSIONS: Intraorbital fibrosclerosing pseudotumors often require a difficult long-term treatment. Therapeutic options are steroid therapy, immunotherapy, radiotherapy and surgery. The diagnostic steps include blood tests, ultrasound, CT and/or MRI as well as histological differentiation. Solid tumors and orbital involvement in diseases of the hematopoetic system have to be excluded. Since intraorbital fibrosis can be accompanied by manifestations in various other organs, a complete investigation of the body and thorough follow up are crucial.


Subject(s)
Exophthalmos/etiology , Orbital Pseudotumor/diagnosis , Adult , Blepharoptosis/etiology , Blepharoptosis/pathology , Blepharoptosis/surgery , Combined Modality Therapy , Decompression, Surgical , Diagnosis, Differential , Exophthalmos/pathology , Exophthalmos/surgery , Female , Fibrosis/pathology , Fibrosis/surgery , Follow-Up Studies , Humans , Lymphocytosis/diagnosis , Lymphocytosis/pathology , Lymphocytosis/surgery , Ocular Motility Disorders/etiology , Ocular Motility Disorders/pathology , Ocular Motility Disorders/surgery , Orbit/pathology , Orbit/surgery , Orbital Pseudotumor/pathology , Orbital Pseudotumor/surgery , Patient Care Team , Recurrence , Reoperation , Visual Acuity/physiology
13.
J Neurosurg ; 105(2): 309-14, 2006 Aug.
Article in English | MEDLINE | ID: mdl-17219839

ABSTRACT

Lymphocytic hypophysitis (LyH) is an uncommon intrasellar lesion characterized by lymphocytic infiltration of the adenohypophysis. Evidence suggests that the cause is autoimmune, and the symptoms are usually related to either a mass effect or endocrine dysfunction. Lymphocytic hypophysitis has been described rarely in the setting of other simultaneous pathological processes that involve the pituitary and sella turcica, and is postulated to arise from an intrinsic inflammatory response. The authors report the case of a 43-year-old woman who presented with a 2-month history of galactorrhea and pseudohyperprolactinemia secondary to a 10-mm lesion within an enlarged pituitary gland. She was nulliparous and had no contributory medical history. Serial neuroimaging performed over a 2-year period demonstrated lesion growth, and visual deficits had developed; together these warranted surgical intervention. A transsphenoidal resection was performed. Microscopic and immunohistopathological examinations revealed a nonsecreting pituitary adenoma with concurrent lymphocytic adenohypophysitis. This is the first documented case of LyH in the setting of a null-cell pituitary adenoma. The authors review the related literature and outline potential mechanisms for the concurrent development of LyH and a pituitary adenoma.


Subject(s)
Adenoma/complications , Lymphocytosis/complications , Pituitary Diseases/complications , Pituitary Neoplasms/complications , Adenoma/diagnosis , Adenoma/pathology , Adenoma/surgery , Adult , Diagnosis, Differential , Female , Galactorrhea/etiology , Galactorrhea/pathology , Galactorrhea/surgery , Humans , Hyperprolactinemia/etiology , Hyperprolactinemia/pathology , Hyperprolactinemia/surgery , Inflammation/complications , Inflammation/diagnosis , Inflammation/pathology , Inflammation/surgery , Lymphocytosis/diagnosis , Lymphocytosis/pathology , Lymphocytosis/surgery , Magnetic Resonance Imaging , Pituitary Diseases/diagnosis , Pituitary Diseases/pathology , Pituitary Diseases/surgery , Pituitary Gland/pathology , Pituitary Neoplasms/diagnosis , Pituitary Neoplasms/pathology , Pituitary Neoplasms/surgery , Sphenoid Bone/surgery
15.
Dis Colon Rectum ; 45(1): 123-6, 2002 Jan.
Article in English | MEDLINE | ID: mdl-11786777

ABSTRACT

PURPOSE: We present a case of severe diarrhea caused by lymphocytic colitis and concurrent celiac sprue in a patient who did not respond to maximal medical therapy and required surgery. METHODS: The patient was initially treated with fecal diversion via an end ileostomy. Six months later, she underwent colectomy and one-stage ileal J-pouch-anal anastomosis. RESULTS: Notably, the characteristic microscopic changes of lymphocytic colitis were still present at the time of colectomy despite diversion. CONCLUSION: Colectomy with continent reconstruction is an option for treatment of patients with lymphocytic colitis refractory to medical therapy.


Subject(s)
Colitis/surgery , Lymphocytosis/surgery , Proctocolectomy, Restorative , Anal Canal/pathology , Anal Canal/surgery , Anastomosis, Surgical , Colitis/pathology , Colon/pathology , Colon/surgery , Female , Humans , Lymphocytosis/pathology , Middle Aged
18.
Neurosurgery ; 34(1): 159-62; discussion 162-3, 1994 Jan.
Article in English | MEDLINE | ID: mdl-8121552

ABSTRACT

Two men undergoing transsphenoidal exploration for pituitary adenoma were found to have lymphocytic hypophysitis. Both presented with frontal headaches, lethargy, and diminished libido. Laboratory investigations showed markedly depressed serum testosterone, and magnetic resonance imaging demonstrated pituitary enlargement, with optic chiasm involvement. Intraoperatively, the dura was adherent to the pituitary in each case. The resected glands were effaced by a dense lymphoplasmacytic infiltrate and fibrosis, without granulomas. Nonspecific peripheral enhancement on imaging suggested a diagnosis other than adenoma, but more experience with peripheral enhancement in lymphocytic hypophysitis is needed. The diagnosis was histological and required surgical intervention. Long-term pituitary replacement therapy is usually required.


Subject(s)
Autoimmune Diseases/diagnosis , Hypopituitarism/diagnosis , Lymphocytosis/diagnosis , Pituitary Diseases/diagnosis , Pituitary Gland/pathology , Adenoma/diagnosis , Adenoma/pathology , Adenoma/surgery , Adult , Autoimmune Diseases/pathology , Autoimmune Diseases/surgery , Diagnosis, Differential , Fibrosis , Humans , Hypopituitarism/pathology , Hypopituitarism/surgery , Lymphocytosis/pathology , Lymphocytosis/surgery , Magnetic Resonance Imaging , Male , Middle Aged , Pituitary Diseases/pathology , Pituitary Diseases/surgery , Pituitary Function Tests , Pituitary Gland/immunology , Pituitary Gland, Anterior/pathology , Pituitary Gland, Anterior/surgery , Pituitary Neoplasms/diagnosis , Pituitary Neoplasms/pathology , Pituitary Neoplasms/surgery , Plasma Cells/pathology
19.
Acta Neurochir (Wien) ; 126(1): 38-43, 1994.
Article in English | MEDLINE | ID: mdl-8154320

ABSTRACT

Specimens of the anterior pituitary lobe were investigated histologically in 28 craniopharyngioma patients operated on trans-sphenoidally. The pituitary glands in 3 patients revealed lymphocytic invasion giving a histological appearance typical of lymphocytic hypophysitis (incidence: 11%). At follow-up examination all three patients with associated lymphocytic hypophysitis had complete pituitary insufficiency, whereas only 36% of the craniopharyngioma patients without associated lymphocytic hypophysitis were in this poor postoperative endocrine state. The phenomenon of associated lymphocytic hypophysitis in craniopharyngioma patients has not been reported so far. This might be due to the fact that investigators have failed to systematically examine the anterior pituitary lobe in craniopharyngioma patients. The 60 cases of lymphocytic hypophysitis reported in the literature occurred, for the most part, in women during late pregnancy or shortly after delivery. An auto-immune origin is assumed in this type of inflammation. In contrast to this pathophysiological mechanism, we assume a local induction of inflammation resulting from the craniopharyngioma cyst in our 3 patients.


Subject(s)
Craniopharyngioma/pathology , Hypopituitarism/pathology , Lymphocytosis/pathology , Pituitary Gland, Anterior/pathology , Pituitary Neoplasms/pathology , Adult , Craniopharyngioma/surgery , Female , Humans , Hypopituitarism/surgery , Inflammation/pathology , Inflammation/surgery , Lymphocytosis/surgery , Male , Middle Aged , Pituitary Gland, Anterior/surgery , Pituitary Hormones, Anterior/blood , Pituitary Neoplasms/surgery
20.
Helv Chir Acta ; 60(1-2): 65-70, 1993 Sep.
Article in French | MEDLINE | ID: mdl-8226085

ABSTRACT

This case illustrates the difficulty of diagnosing a colonic stenosis of ischemic origin. A 70-year-old lady presents with abdominal pain, fever and melaena. Lc are 15.2, ESR 39 mm, CEA 2.7 ng/ml. A barium enema shows a stenosis of the transverse colon that is suspicious of neoplasia. At time of operation, an induration of the transverse colon is found with edema of the corresponding mesocolon but no tumour is palpated. A resection of this area is performed and an end to end anastomosis performed. Pathology shows an ischemic colitis secondary to a lymphocytic thrombotic venulitis. The patient is discharged home one month postoperatively. 4 weeks later she is readmitted with the same symptoms. A gastrograffin enema shows a similar stenosis in the transverse colon including the anastomosis. The diagnosis is made of a recurrent ischemic stenosis. The patient improves over a 10-day period of conservative treatment (anticoagulation, TPN, steroids). A control barium enema shows a near resolution of the stenosis. The majority of ischemic colitis are of arterial origin nevertheless ischemic colitis of venous origin exists. The factor causing venous ischemia are not known. It is though thought to be associated with hypersensitivity vasculitis of drug origin. Its initial diagnosis versus neoplasia is difficult but once made there is a good response to a conservative treatment.


Subject(s)
Colitis, Ischemic/surgery , Colonic Diseases/surgery , Intestinal Obstruction/surgery , Lymphocytosis/surgery , Thrombosis/surgery , Vasculitis/surgery , Aged , Colitis, Ischemic/pathology , Colon/blood supply , Colonic Diseases/pathology , Diagnosis, Differential , Female , Humans , Intestinal Obstruction/pathology , Lymphocytosis/pathology , Thrombosis/pathology , Vasculitis/pathology , Venules/pathology
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