ABSTRACT
A 13-year-old boy with evidence of pulmonary lymphomatoid granulomatosis developed monocular diplopia. Fluorescein angiography revealed bilateral choroidal involvement. Following treatment with vincristine, cyclophosphamide, and prednisone his diplopia resolved and the angiographic appearances returned to normal.
Subject(s)
Choroid Neoplasms/secondary , Lung Neoplasms/pathology , Lymphomatoid Granulomatosis/secondary , Adolescent , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Choroid Neoplasms/complications , Choroid Neoplasms/drug therapy , Cyclophosphamide/administration & dosage , Diplopia/etiology , Fluorescein Angiography , Humans , Lymphomatoid Granulomatosis/drug therapy , Male , Prednisone/administration & dosage , Vincristine/administration & dosageSubject(s)
Dog Diseases/pathology , Lung Neoplasms/veterinary , Lymphomatoid Granulomatosis/veterinary , Adrenal Gland Neoplasms/secondary , Adrenal Gland Neoplasms/veterinary , Animals , Dogs , Female , Heart Neoplasms/secondary , Heart Neoplasms/veterinary , Kidney/pathology , Kidney Neoplasms/secondary , Kidney Neoplasms/veterinary , Liver Neoplasms/secondary , Liver Neoplasms/veterinary , Lung/pathology , Lung Neoplasms/pathology , Lymphatic Metastasis , Lymphomatoid Granulomatosis/pathology , Lymphomatoid Granulomatosis/secondary , Male , Pancreatic Neoplasms/secondary , Retrospective Studies , Splenic Neoplasms/secondary , Splenic Neoplasms/veterinaryABSTRACT
Lymphomatoid granulomatosis is an angiocentric, lymphoproliferative disease of the lung, which frequently involves extrapulmonary sites. Controversy persists over whether this process represents malignant lymphoma from its inception. Historically, the disease generally carries a poor prognosis but aggressive chemotherapy has resulted in improved survival. We describe a patient who presented with bladder outlet obstruction resulting from prostatic infiltration by this angiocentric lymphoproliferative disease. The clinical manifestations, pathological appearance and therapeutic options are reviewed.
