ABSTRACT
The topic of fertility preservation in patients with a lymphoproliferative disease offers new aspects of debate, due to the introduction of novel chemotherapeutic regimens and small molecules in the clinical landscape. Cancer related infertility is mostly dependent on gonadotoxic treatments and fertile female patients are today addressed to the oocyte cryopreservation or to ovarian cortex fragment cryopreservation. These methods present advantages and disadvantages, which will be discussed in the present review, together with the options for male patients. The recent discovery of functional ovarian stem cells (OCSs) in woman ovarian cortex, opens new avenues offering a innovative procedure for fertility preservation through as model of regenerative medicine. Here, we review the gonadotoxic potential of "classical" chemotherapeutic treatments as well as of "novel" targeted therapies actually employed for lymphoproliferative neoplasms in young patients and revisit both the today available and future chances to preserve and restore fertility after the cancer healing.
Subject(s)
Antineoplastic Agents/adverse effects , Fertility Preservation , Fertility/drug effects , Lymphoproliferative Disorders/diet therapy , Neoplasms/drug therapy , Ovary/drug effects , Primary Ovarian Insufficiency/chemically induced , Cryopreservation , Female , Humans , Lymphoproliferative Disorders/pathology , Male , OocytesABSTRACT
Chronic cough is a common reason for presentation to a respiratory clinic. In up to 20% of cases the cause remains unclear after investigations. We report one such case where there was bronchoscopic evidence of lymphocytic airway inflammation in association with newly diagnosed coeliac disease. All features improved markedly on a gluten free diet, suggesting a causal relationship between coeliac disease, cough, and lymphocytic bronchoalveolitis.
Subject(s)
Bronchitis/diet therapy , Celiac Disease/diet therapy , Cough/diet therapy , Lymphoproliferative Disorders/diet therapy , Pneumonia/diet therapy , Aged , Bronchitis/etiology , Celiac Disease/etiology , Chronic Disease , Cough/etiology , Diet, Protein-Restricted/methods , Glutens , Humans , Lymphoproliferative Disorders/etiology , Male , Pneumonia/etiology , Pulmonary Alveoli , Treatment OutcomeABSTRACT
A case of lymphangiomyoma, manifested by chylous ascites, in a 32 year-old woman is presented. Treatment with dietary fat restriction supplemented with medium chain triglycerides was successful, and the patient has remained free from chylous effusions for nearly two years.
Subject(s)
Lymphangiomyoma/diet therapy , Lymphoproliferative Disorders/diet therapy , Peritoneal Neoplasms/diet therapy , Adult , Ascites/etiology , Chylous Ascites/diagnosis , Dietary Fats/administration & dosage , Female , Humans , Triglycerides/administration & dosageABSTRACT
Restriction of calorie intake from the time of weaning greatly prolongs life, and it inhibits development and expression of the lymphoproliferative syndrome, renal disease, and decline of certain immunologic functions with age in MRL/lpr mice. This dramatic influence of diet on mice of this short-lived autoimmunity-prone strain, while associated with decreased rate of growth, is not associated with debilitation or apparent disease in the MRL/lpr mice. The massive lymphadenopathy and splenomegaly that developed in the putatively well-fed animals was prevented by dietary restriction, as were histopathologic abnormalities of thymus, spleen, lymph nodes, and kidneys.
