Subject(s)
Ascomycota/pathogenicity , Chorioretinitis/microbiology , Mitosporic Fungi/pathogenicity , Stem Cell Transplantation/adverse effects , Adult , Antifungal Agents/therapeutic use , Ascomycota/isolation & purification , Chorioretinitis/drug therapy , Chorioretinitis/etiology , Fluorescein Angiography , Humans , Macula Lutea/microbiology , Male , Mitosporic Fungi/isolation & purification , Onychomycosis/drug therapy , Triazoles/therapeutic useABSTRACT
Presumed ocular histoplasmosis syndrome is a macular hemorrhagic choroiditis of the young adult. The etiology of this syndrome is uncertain, but can be correlated with some positive reactions to histoplasmosis. The study was carried out on 12 patients, each of them was investigated by functional and objective ocular examinations, laboratory tests, fluorescein angiography and ultrasound examinations. The clinical signs of this syndrome of presumed ocular histoplasmosis were: macular focal lesions, subretinian hemorrhages, detachment of the retinal neurosensorial layer, presence of disseminated choroiditis scars and subretinian neovascularization. The correct evaluation of the choriocapillary perfusion is helpful to institute a proper therapy.
Subject(s)
Eye Infections, Fungal/diagnosis , Histoplasmosis/diagnosis , Adult , Animals , Choroidal Neovascularization/microbiology , Choroidal Neovascularization/pathology , Female , Fluorescein Angiography , Humans , Macula Lutea/microbiology , Macula Lutea/pathology , Male , SyndromeABSTRACT
PURPOSE: To report a previously undescribed cause of bilateral macular hole formation. METHOD: Case report. RESULTS: Septic emboli were noted at the center of the macula in both eyes of a 32-year-old man with acute bacterial endocarditis. Bilateral full-thickness macular holes later developed at the site of these retinal lesions. CONCLUSION: This case represents the first report of fundus lesions in septicemia resulting in full-thickness macular hole formation.
