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ACS Appl Mater Interfaces ; 13(30): 35376-35388, 2021 Aug 04.
Article in English | MEDLINE | ID: mdl-34313109

ABSTRACT

Escorting therapeutics for malignancies by nano-encapsulation to ameliorate treatment effects and mitigate side effects has been pursued in precision medicine. However, the majority of drug delivery systems suffer from uncontrollable drug release kinetics and thus lead to unsatisfactory triggered-release efficiency along with severe side effects. Herein, we developed a unique nanovesicle delivery system that shows near-infrared (NIR) light-triggered drug release behavior and minimal premature drug release. By co-encapsulation of superparamagnetic iron oxide (SPIO) nanoparticles, the ultrasound contrast agent perfluorohexane (PFH), and cisplatin in a silicate-polyaniline vesicle, we achieved the controllable release of cisplatin in a thermal-responsive manner. Specifically, vaporization of PFH triggered by the heat generated from NIR irradiation imparts high inner vesicle pressure on the nanovesicles, leading to pressure-induced nanovesicle collapse and subsequent cisplatin release. Moreover, the multimodal imaging capability can track tumor engagement of the nanovesicles and assess their therapeutic effects. Due to its precise inherent NIR-triggered drug release, our system shows excellent tumor eradication efficacy and biocompatibility in vivo, empowering it with great prospects for future clinical translation.


Subject(s)
Antineoplastic Agents/therapeutic use , Cisplatin/therapeutic use , Contrast Media/chemistry , Drug Carriers/chemistry , Fluorocarbons/chemistry , Neoplasms/drug therapy , A549 Cells , Aniline Compounds/chemistry , Aniline Compounds/radiation effects , Aniline Compounds/toxicity , Animals , Antineoplastic Agents/chemistry , Antineoplastic Agents/toxicity , Cisplatin/chemistry , Cisplatin/toxicity , Contrast Media/toxicity , Drug Carriers/radiation effects , Drug Carriers/toxicity , Drug Liberation , Drug Therapy , Fluorocarbons/toxicity , Humans , Infrared Rays , Magnetic Iron Oxide Nanoparticles/chemistry , Magnetic Iron Oxide Nanoparticles/radiation effects , Magnetic Iron Oxide Nanoparticles/toxicity , Mice, Nude , Photothermal Therapy , Silicates/chemistry , Silicates/toxicity , Xenograft Model Antitumor Assays
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