Subject(s)
Iodine/poisoning , Adolescent , Humans , Male , Mediastinum/metabolism , Povidone-Iodine/therapeutic use , Therapeutic IrrigationABSTRACT
Sixty consecutive patients, except for one 7-year-old patient, their ages varying from 1 day to 12 months received total intravenous hyperalimentation (TIH). It was possible to observe non-pathological catheter malpositions and, in 14 patients, other complications. The most serious complications observed included the following: thrombus and pericatheter thrombus calcification; superior vena cava thrombotic occlusion; hydrothorax; mediastinal effusion; generalized septic arthritis; venous transfixion with flooding of the soft tissues of the neck; vein wall lesions; collateral vertebral circulation; and a catheter tip blocked in vein. A brief comment is given on the use of this procedure and what may happen.
Subject(s)
Parenteral Nutrition, Total/adverse effects , Parenteral Nutrition/adverse effects , Arthritis, Infectious/etiology , Calcinosis/diagnostic imaging , Calcinosis/etiology , Catheters, Indwelling/adverse effects , Child , Exudates and Transudates/metabolism , Female , Humans , Hydrothorax/diagnostic imaging , Hydrothorax/etiology , Infant , Infant, Newborn , Male , Mediastinum/diagnostic imaging , Mediastinum/metabolism , Radiography , Thrombosis/diagnostic imaging , Thrombosis/etiology , Veins/injuries , Vena Cava, SuperiorABSTRACT
After incidentally observing a patient in whom abnormal uptake of gallium-67 citrate appeared to be explained by treatment with phenytoin, we have conducted a prospective study. Of sixteen persons with a seizure disorder treated with phenytoin, five (31%) had abnormal uptake of radiogallium either in the mediastinum, pulmonary hilum or both. Of nineteen historical control patients only one had such abnormal uptake. Phenytoin may thus cause the false-positive uptake of radiogallium in lymph nodes; this finding may also prove to have nosological importance in identifying patients at particular risk of the side-effects of this drug.
