ABSTRACT
BACKGROUND: Neonatal respiratory distress due to coexisting subglosso-palatal membrane and tongue dermoid has not been reported yet. CASE CHARACTERISTICS: A newborn with respiratory distress having a membrane in the oral cavity. Excision of membrane revealed a tongue mass with cleft palate, obstructing the nasopharynx completely. Elective ventilation was followed by excision of mass. OUTCOME: The child was cured with uneventful course at follow-up of six months. MESSAGE: Co-existing congenital anomalies causing airway obstruction may be missed in presence of subglosso-palatal membrane.
Subject(s)
Abnormalities, Multiple/diagnosis , Cleft Palate/diagnosis , Dermoid Cyst/diagnosis , Palate/abnormalities , Respiratory Distress Syndrome, Newborn/etiology , Tongue Neoplasms/diagnosis , Tongue/abnormalities , Cleft Palate/complications , Dermoid Cyst/complications , Humans , Infant, Newborn , Male , Membranes/abnormalities , Tongue Neoplasms/complicationsABSTRACT
A 20-year-old woman, a registered nurse, presented with best-corrected visual acuity of 6/15 (20/50) due to bilateral extensive persistent pupillary membrane. Sequential argon laser photocoagulation of the iris strands at the pupillary membrane iris collarette followed by neodymium:YAG laser lysis resulted in partial clearing of the central visual axis without bleeding. Best-corrected visual acuity improved to 6/9 (20/30) bilaterally without complications noted 1â year after combined laser therapy.
Subject(s)
Eye Abnormalities/surgery , Iris Diseases/surgery , Iris/abnormalities , Laser Therapy/methods , Membranes/abnormalities , Pupil Disorders/surgery , Vision, Low/etiology , Adult , Argon , Female , Humans , Iris/surgery , Laser Coagulation , Lasers, Solid-State , Membranes/surgery , Pupil , Vision, Low/surgery , Visual Acuity , Young AdultABSTRACT
Los nacimientos prematuros son un gran problema en el mundo y la ruptura prematura de membranas contribuyen en cerca de un tercio a esa prematuridad. En Latino América aproximadamente uno de cada 7 nacimientos es prematuro y la ruptura de membranas y trastornos hipertensivos son la principal causa. Una vez confirmada la ruptura de membranas en especial las lejos del término, estamos ante una complicación obstétrica que amerita manejo muy específico y basado en pruebas (evidencia)...
Subject(s)
Female , Pregnancy Complications/diagnosis , Pregnancy Complications/prevention & control , Gestational Age , Membranes/abnormalities , Membranes/growth & developmentABSTRACT
The left atrial appendage (LAA) is a blind-ending, complex structure distinct from the body of the left atrium and is sometimes regarded as a minor extension of the atrium. However, it should routinely be evaluated as part of a transesophageal echocardiographic examination. In this study we describe the presence of a nonobstructive membrane traversing the cavity of the LAA, found incidentally on transesophageal echocardiography.
Subject(s)
Atrial Appendage/abnormalities , Atrial Appendage/diagnostic imaging , Echocardiography/methods , Heart Septal Defects, Atrial/diagnostic imaging , Adult , Humans , Male , Membranes/abnormalities , Membranes/diagnostic imaging , Rare Diseases/diagnostic imagingABSTRACT
Anionic polymers are valuable components used in cosmetics and health sciences, especially in drug delivery, because of their chemical versatility and low toxicity. However, because of their highly negative charge they pose problems for penetration through hydrophobic barriers such as membranes. We have engineered anionic polymalic acid (PMLA) to penetrate biological membranes. PMLA copolymers of leucine ethyl ester (P/LOEt) or trileucine (P/LLL) show either pH-independent or pH-dependent activity for membrane penetration. We report here for the first time on the mechanisms which are different for those two copolymers. Formation of hydrophobic patches in either copolymer is detected by fluorescence techniques. The copolymers display distinctly different properties in solution and during membranolysis. P/LOEt copolymer binds to membrane as single molecules with high affinity, and induces leakage cooperatively through a mechanism known as "carpet" model, in which the polymer aligns at the surface throughout the entire process of membrane permeation. In contrast, P/LLL self-assembles to form an oligomer of 105 nm in a pH-dependent manner (pKa 5.5) and induces membrane leakage through a two-phase process: the concentration dependent first-phase of insertion of the oligomer into membrane followed by a concentration independent second-phase of rearrangement of the membrane-oligomer complex. The insertion of P/LLL is facilitated by hydrophobic interactions between trileucine side chains and lipids in the membrane core, resulting in transmembrane pores, through mechanism known as "barrel-stave" model. The understanding of the mechanism paves the way for future engineering of polymeric delivery systems with optimal cytoplasmic delivery efficiency and reduced systemic toxicity.
Subject(s)
Malates/pharmacology , Polymers/pharmacology , Esters/chemistry , Fluorescence Resonance Energy Transfer , Hydrodynamics , Hydrogen-Ion Concentration/drug effects , Hydrophobic and Hydrophilic Interactions/drug effects , Kinetics , Liposomes/chemistry , Malates/chemical synthesis , Malates/chemistry , Membranes/abnormalities , Microscopy, Confocal , Oligopeptides/chemistry , Particle Size , Permeability/drug effects , Polymers/chemical synthesis , Polymers/chemistry , Rhodamines/metabolism , Solutions , TemperatureABSTRACT
Se realizó un estudio transversal y retrospectivo sobre los 11 pacientes atendidos en el Servicio de Otorrinolaringología del Hospital infantil Sur de Santiago de Cuba con el diagnóstico de imperforación de coanas, donde se expone la experiencia del equipo médico en el tratamiento de estos niños durante más de 30 años de trabajo (1970-2000).
A retrospective and cross-sectional study was conducted in 11 patients diagnosed with imperforate choanas, who were attended in the Otorhinolaringology Service of the Southern Children Hospital from Santiago de Cuba, where the experience of the medical team in the treatment of these children for more than 30 working years (1970-2000) is stated.
Subject(s)
Humans , Male , Female , Infant, Newborn , Choanal Atresia/surgery , Choanal Atresia/diagnosis , Methylene Blue , Congenital Abnormalities , Emergencies , Membranes/abnormalities , Cross-Sectional Studies , Retrospective StudiesABSTRACT
Se realizó un estudio transversal y retrospectivo sobre los 11 pacientes atendidos en el Servicio de Otorrinolaringología del Hospital infantil Sur de Santiago de Cuba con el diagnóstico de imperforación de coanas, donde se expone la experiencia del equipo médico en el tratamiento de estos niños durante más de 30 años de trabajo (1970-2000)(AU)
A retrospective and cross-sectional study was conducted in 11 patients diagnosed with imperforate choanas, who were attended in the Otorhinolaringology Service of the Southern Children Hospital from Santiago de Cuba, where the experience of the medical team in the treatment of these children for more than 30 working years (1970-2000) is stated(AU)
Subject(s)
Humans , Male , Female , Infant, Newborn , Choanal Atresia/diagnosis , Methylene Blue , Congenital Abnormalities , Membranes/abnormalities , Choanal Atresia/surgery , Emergencies , Cross-Sectional Studies , Retrospective StudiesABSTRACT
A persistent buccopharyngeal membrane is a rare entity with 23 reported cases in the literature. Patients often present at birth in airway distress with diagnosis initially unrecognized. The otolaryngologist is frequently consulted in the delivery room to establish a secure airway after attempts at direct laryngoscopy are unsuccessful. Historically, definitive treatment has proved challenging. This article presents a new case and thoroughly reviews the literature for previous cases. Embryology, presentation, and treatment options are outlined.
Subject(s)
Membranes/abnormalities , Pharynx/abnormalities , Female , Humans , Infant, Newborn , Magnetic Resonance ImagingSubject(s)
Fourth Ventricle/abnormalities , Fourth Ventricle/pathology , Hydrocephalus/pathology , Subarachnoid Space/pathology , Arachnoid/abnormalities , Arachnoid/pathology , Cerebrospinal Fluid Pressure/physiology , Fourth Ventricle/physiopathology , Humans , Hydrocephalus/etiology , Hydrocephalus/physiopathology , Magnetic Resonance Imaging , Male , Medulla Oblongata/abnormalities , Medulla Oblongata/pathology , Medulla Oblongata/physiopathology , Membranes/abnormalities , Membranes/pathology , Middle Aged , Subarachnoid Space/physiopathology , Treatment Outcome , VentriculostomyABSTRACT
Total anomalous pulmonary venous connection is rarely associated with a supramitral ring. This condition should be suspected in any infant having total anomalous pulmonary venous connection with obstruction to the pulmonary venous return. Preoperative echocardiography is usually successful in detecting the lesion. The Shumaker and King repair for total anomalous pulmonary venous connection is most appropriate for such composite lesions as it enables the surgeon to identify the membrane and excise it easily and completely. We report one such case.
Subject(s)
Mitral Valve Stenosis/congenital , Mitral Valve/abnormalities , Pulmonary Veins/abnormalities , Abnormalities, Multiple/diagnostic imaging , Abnormalities, Multiple/surgery , Brachiocephalic Veins/abnormalities , Brachiocephalic Veins/surgery , Cardiomegaly/etiology , Cardiopulmonary Bypass , Ductus Arteriosus, Patent/diagnostic imaging , Ductus Arteriosus, Patent/surgery , Failure to Thrive/etiology , Heart Arrest, Induced , Heart Septal Defects, Atrial/diagnostic imaging , Heart Septal Defects, Atrial/surgery , Humans , Hypothermia, Induced , Infant , Membranes/abnormalities , Membranes/diagnostic imaging , Membranes/surgery , Mitral Valve/diagnostic imaging , Mitral Valve/surgery , Mitral Valve Stenosis/etiology , Mitral Valve Stenosis/surgery , Pulmonary Veins/diagnostic imaging , Pulmonary Veins/surgery , UltrasonographyABSTRACT
We report a case of Budd-Chiari syndrome due to membranous obstruction of the inferior vena cava with a congenital malformation composed of a left inferior vena cava at the sub-renal level with an azygo-caval continuation without a retrohepatic segment of the inferior vena cava. To our knowledge, this is the first report of this association. The congenital venous malformation suggests a congenital etiology to the inferior vena cava membrane. The membranous obstruction was treated by percutaneous transluminal angioplasty. During the 10-year follow-up, there was no recurrence of the membranous obstruction as seen with Doppler ultrasound and magnetic resonance imaging.
Subject(s)
Angioplasty, Balloon, Coronary , Budd-Chiari Syndrome/etiology , Vascular Diseases/pathology , Vena Cava, Inferior/abnormalities , Adult , Budd-Chiari Syndrome/therapy , Constriction, Pathologic , Female , Follow-Up Studies , Humans , Membranes/abnormalities , Tomography, X-Ray Computed , Vascular Diseases/congenital , Vascular Diseases/therapyABSTRACT
Multiple abnormal pharyngeal and pharyngolaryngeal bands were present in a child presenting with diffuse interstitial pulmonary fibrosis. The soft palate was fused to the posterior pharyngeal wall. Instead of there being facial pillars, a muscular band on either side extended from the base of the tongue to the lateral pharyngeal walls. There was neither tonsil nor adenoid tissue present. The epiglottis was tethered to the posterior pharyngeal wall by bands from its lateral aspects. The right arytenoid mound was tethered to the posterior wall of the hypopharynx. It is postulated that these arose from a failure of development of the second branchial pouch.
Subject(s)
Larynx/abnormalities , Pharynx/abnormalities , Pulmonary Fibrosis/complications , Branchial Region/abnormalities , Child , Humans , Larynx/embryology , Larynx/surgery , Laser Therapy , Male , Membranes/abnormalities , Membranes/embryology , Membranes/surgery , Pharynx/embryology , Pharynx/surgeryABSTRACT
Reportamos el caso de un paciente masculino de 44 años de edad, con limitación en la apertura bucal posterior a accidente de tránsito, quien fue programado para amputación infracondilea del miembro inferior derecho, bajo anestesia general. Por resultar fallidos múltiples intentos de intubación orotraqueal se decide iniciar la Ventilación Jet Transtraqueal (VJTT), a través de un catéter Nº14 colocado a través de la membrana cricotiroidea, con una presión de 30 PSI; siendo adecuada la oxigenación y ventilación durante todo el procedimiento quirúrgico. No se presentó ninguna complicación en el trans y postoperatorio. Este reporte es el primer caso de VJTT usada en una emergencia en el Hospital Militar "Dr. Carlos Arvelo"
Subject(s)
Humans , Male , Adult , Anesthesia/statistics & numerical data , General Surgery/methods , Intubation/methods , Membranes/abnormalities , Trachea/abnormalitiesSubject(s)
Dogs/abnormalities , Iris/abnormalities , Animals , Female , Male , Membranes/abnormalitiesABSTRACT
Otoconial membranes from a large number of normal albino and pigmented guinea pigs were examined by light microscopy. In more than 20% of the animals, microdissection revealed that the crystalline layer of the otoconial membrane was incomplete, leaving large areas of the underlying gelatinous layer uncovered by crystals. These defects were bilateral, more or less symmetrical, and invariably more extensive in the saccule than in the utricle. In two animals, huge single conglomerates of crystals were found on both the saccular and utricular maculae. None of the animals displayed abnormal behavior or posture and no obvious cause for the otoconial defects was found. The presence of a hereditary congenital condition is postulated. The high incidence of otoconial defects in guinea pigs makes them poorly suited for most investigations of experimentally induced pathology. Therefore, previous reports of otoconial pathology in guinea pigs should be viewed in the light of these findings.
