[Sensitivity of Pseudomonas mallei to tetracyclines and their effectiveness in experimental glanders]. / Chuvstvitel'nost' Pseudomonas mallei k tetratsiklinam i ikh éffektivenost' pri éksperimental'nom sape.

MICs and MBcCs of minocycline, doxycycline, methacycline and chlortetracycline for 8 strains of Pseudomonas mallei were determined. The chemotherapeutic efficacy of minocycline and doxycycline was studied on golden hamsters and their efficacy indices were estimated in comparison with those of chlortetracycline in the prophylaxis and treatment of experimental malleus. Minocycline was shown to be the most efficient drug in the treatment of malleus. Doxycycline in a dose of 0.25 mg/kg practically had the same efficacy as chlortetracycline in a dose of 25 mg/kg. Methacycline was inefficient.

[A case of severe methacycline damage to the liver and bone marrow]. / Vurkhu edin sluchai s tezhko metatsiklinovo uvrezhdane na cherniia drob i kostniia mozuk.

A case of a male patient with bronchopneumonia incorrectly treated for a long time with methacycline (rondomycin), an oxytetracycline drug, is reported. methacycline was applied in a dose of 8 capsules daily (2 capsules 4 times) in the course of 2 1/2 months, the total dose amounting to about 150 g. The patient developed severe toxic hepatitis as a result of this incorrect treatment. The hepatitis was manifested by jaundice and cytolysis. The bone marrow was also affected--hypoplasia marked by combined depression of leuko-, erythro- and thrombopoiesis and peripheral pancytopenia. In addition chloramphenicol treatment was applied which increased the toxic impairment of the liver and the bone marrow. The liver and bone marrow impairment are most probably due to the direct toxic action of methacycline applied for a very long time in an unusually high dose.

[Drug induced esophageal ulcers]. / Das medikamentös bedingte Osophagusulkus.

Drug induced esophageal ulcers are more frequent than supposed. Four ulcerative lesions of the esophagus, two after ingestion of doxycycline-hydrochloride, one after metacycline-hydrochloride, and one after emeproniumbromide were detected at the department of Internal Medicine of a medium-sized standard-hospital during the last six years. Symptoms develop suddenly after taking the drug with minimum fluid, usually before going to bed. Retrosternal burning, odynophagia and dysphagia are pathognomonic features. The cause of ulceration is discussed to be a matter of the drug remaining in the esophagus and of its local cytolytic and corrosive effect. Cytomegalo and herpes-simplex-infections can be excluded as etiologic factor of such ulcers. The clinical diagnosis is verified by endoscopy only.

Methacycline hyperpigmentation: a five-year follow-up.

A five-year follow-up is presented of a unique material of patients who acquired a greyish black hyperpigmentation during long-term methacycline therapy for chronic bronchitis. The melanosis disappeared in cases in which tetracycline therapy was discontinued during the observation period but not in those in which doxycycline had been substituted. In two autopsy cases pigment deposits were also found in cartilage and atherosclerotic lesions. Overall clinical and microscopic findings suggest a similarity to the pigmentation occurring in iatrogenic ochronosis.

[Hemorrhagic lesion of the sciatic nerve caused by chronic infection and iatrogenic factors]. / Krwotoczne uszkodzenie nerwu kulszowego wywolane przewleklym zakazeniem i jatrogennymi czynnikami.

The author reports a 50-year-old woman with haemorrhagic lesion to the sciatic nerve during a chronic infectious process and treatment with chemotherapeutic agents. The nerve was damaged by pressure exerted by extravasated blood or haemorrhage from vasa nervorum.

Methacycline compared with ampicillin in acute bacterial exacerbations of chronic bronchitis. A double-blind crossover study.

In order to objectively document the accepted clinical efficacy of ampicillin in treating bacterial exacerbations of chronic bronchitis, as well as to evaluate the efficacy of methacycline, a double-blind crossover study was designed. Twenty patients with chronic bronchial disease were treated for two separate acute bacterial exacerbations, once with 2 gm of ampicillin daily, and once with 600 mg of methacycline daily, for 14 days. There were a few significant differences when comparing the efficacy of the antimicrobials. For example, the daily volume of sputum significantly went from 35.6 ml initially to 20.5 ml at the end of treatment with methacycline, and from 37.4 to 18.0 ml with ampicillin. Sputum neutrophils excreted per day went from 446 to 147 million with methacycline and from 433 to 94 million with ampicillin. Gram-positive diplococci and cocci on gram stains of sputum significantly decreased form 10.6 to 3.3 with methacycline and from 16.8 to 2.1 with ampicillin. This investigation objectively documents with accepted clinical efficacy of ampicillin and proves methacycline to be an equally effective agent.