1.
Eur J Pharmacol
; 44(4): 387-90, 1977 Aug 15.
Article
in English
| MEDLINE
| ID: mdl-19268
ABSTRACT
The dopamine beta-hydroxylase inhibitors, FLA-63 and picolinic acid, antagonized the anticonvulsant action of methazolamine in mice; disulfiram and pyrimidinethiol were inactive. FLA-63 and picolinic acid, but not disulfiram or pyrimidinethiol prevented pheniprazine restoration of the anticonvulsant action of methazolamide in reserpinized mice. The present findings clearly demonstrate that differences exist among inhibitors of dopamine beta-hydroxylase regarding their ability to antagonize the anticonvulsant action of methazolamide under various test conditions.
Subject(s)
Anticonvulsants/antagonists & inhibitors , Dopamine beta-Hydroxylase/antagonists & inhibitors , Methazolamide/antagonists & inhibitors , Thiadiazoles/antagonists & inhibitors , Animals , Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide/pharmacology , Disulfiram/pharmacology , Female , Hydrazines/antagonists & inhibitors , Hydrazines/pharmacology , Methazolamide/pharmacology , Mice , Picolinic Acids/pharmacology , Pyrimidines/pharmacology
2.
J Pharmacol Exp Ther
; 177(1): 206-18, 1971 Apr.
Article
in English
| MEDLINE
| ID: mdl-4254846
Subject(s)
Amines/analysis , Anticonvulsants/pharmacology , Brain Chemistry/drug effects , Carbonic Anhydrase Inhibitors/pharmacology , Animals , Dopamine/metabolism , Drug Synergism , Fenclonine/pharmacology , Male , Methazolamide/antagonists & inhibitors , Methazolamide/pharmacology , Methyltyrosines/pharmacology , Norepinephrine/metabolism , Phenytoin/pharmacology , Rats , Reserpine/pharmacology , Serotonin/metabolism
3.
J Pharmacol Exp Ther
; 163(2): 431-8, 1968 Oct.
Article
in English
| MEDLINE
| ID: mdl-5681182
