ABSTRACT
In addition to methods for the determination of residues, there is an important need for knowledge of the fate and excretion of growth promoting substances in fattening animals. In court, often simple questions are asked, such as, over what period of time can the drug be detected?, is it possible to find residues after 2 months, etc. These questions can only be answered by conducting animal experiments. Data on excretion and distribution of thiouracils in cows are rather scarce. At the beginning of the 1980s, animal experiments with methylthiouracil (MTU) were carried out in the Laboratory of Chemical Analysis. These experiments showed that treatment of cows with MTU results in the rapid appearance of the drug in plasma, urine and milk, whereas MTU selectively accumulates in the thyroid gland. The results of these experiments were only published in media with limited access (thesis, abstracts) and also there has been a considerable improvement in data handling with computer programs in the last 15 years. This investigation reinterprets the 'old' analytical data from animal experiments using a pharmacokinetic software package.
Subject(s)
Antithyroid Agents/metabolism , Cattle/metabolism , Drug Residues/analysis , Methylthiouracil/metabolism , Administration, Oral , Animals , Antithyroid Agents/administration & dosage , Antithyroid Agents/analysis , Data Interpretation, Statistical , Methylthiouracil/administration & dosage , Methylthiouracil/analysis , Milk/chemistry , Muscle, Skeletal/chemistry , Thyroid Gland/chemistrySubject(s)
Antithyroid Agents/adverse effects , Adolescent , Adult , Aged , Antithyroid Agents/metabolism , Carbimazole/adverse effects , Carbimazole/metabolism , Child , Child, Preschool , Female , Humans , Infant , Infant, Newborn , Male , Methimazole/adverse effects , Methimazole/metabolism , Methylthiouracil/adverse effects , Methylthiouracil/metabolism , Middle Aged , Pregnancy , Product Surveillance, Postmarketing , Propylthiouracil/adverse effects , Propylthiouracil/metabolism , Risk FactorsABSTRACT
In 82 albino rats with experimental thyrotoxicosis the assimilation of parenterally administered amino acid mixture of mori-amine S-2 was investigation. In thyrotoxicosis the assimilation of the amino acid mixture was found to be down. It is only a combination of mori-amine S-2 with vitamins, hormones and 6-methyluracil that facilitates the utilization of free amino acids by the tissues (this being borne out by a falling level of aminic nitrogen in the blood, skeletal muscles, heart and liver), persistently upholds the positive nitrous balance, prevents losses of the body weight and foces down oxygen consumption.
