[Inhibitory effect of a number of substances on manifestation of the embryotoxic and teratogenic effects of methylurea and sodium nitrite]. / Tormoziashches vliianie riada veshchestv na proiavlenie embriotoksicheskogo i teratogennogo deistviia metilmocheviny i nitrita natriia

Embryos died and a teratogenic effect followed combined intragastric administration of methylurea (MU) and sodium nitrite (SN) to rats on the 9th day of pregnancy; this was caused by the endogenous synthesis of nitroso-methylurea which produced a pathogenic action. Ascorbic acid and urotropine completely blocked the possibility of manifestation of the embryotoxic and teratogenic effect occuring after combined administration of MU and SN. Sodium sulfomate decreased the embryotoxic and partially the teratogenic effect considerably, whereas urea failed to prevent the expression of the harmful effect of MU and SN on the embryo.