ABSTRACT
Patients with cutaneous nodules, ulcers, granulomas, sinus tracto, and abscesses are included in this study. Patients were referred fro therapy with an experimental drug, largely because of failure to respond to earlier therapy, relapse after earlier therapy, or toxicity of early therapy. The etiologic diagnosis was confirmed by fungal culture or histopathology and by serology. In some cases cultures or biopsies had been obtained up for months before imidazole treatment, but the lesions had failed to heal on earlier treatment or had relapsed in the same site following apparently successful earlier therapy. One patient in the ketoconazole group had a progressive primary cutaneous infection, originating in a cactus-thorn puncture, before therapy, all the others had disseminated disease. One Miconazole patient had miliary disseminated disease
