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1.
Ther Umsch ; 68(10): 559-64, 2011 Oct.
Article in German | MEDLINE | ID: mdl-21968895

ABSTRACT

Malignant mesodermal tumors of the uterus are an inhomogenous group of uterine malignancies with different pathogenesis, clinical presentation and prognosis. These rare tumors represent approximately 1 % of all uterine malignancies. The aggressive carcinosarcomas or mixed muellerian tumors are defined by mixed malignant epithelial and malignant mesodermal histopathology and are of the same precursor cell origin like endometrial cancer. Thus, carcinosarcomas were reclassified by the FIGO as an aggressive type of endometrial cancer and treated like type II endometrial cancer. Adenosarcomas are also mixed tumors with benign epithelial proliferation and malignant mesodermal cell growth, have a good prognosis and represent less than 5 % of all mesodermal uterine malignancies. Besides carcinosarcomas, the pure mesodermal leiomyosarcomas are the most common mesodermal malignancies. Patients with leiomyosarcamos are usually perimenopausal, and although more than half of the patients present with symptoms, diagnosis occurs incidentally in most cases in final histopathologic workup of an excised putative myoma or uterus. Adequate anamnesis, gynecologic examination and careful imaging by transvaginal ultrasound in the preoperative setting might hint to correct differential diagnosis in many cases. Overall the prognosis of uterine leiomyomas is poor. Malignancies of the endometrial stroma are very rare and divided in two subgroups, the mostly estrogen receptor positive endometrial stromal sarcoma, which occur preferably in premenopausal women and show a favorable prognosis, and the very aggressive undifferentiated endometrial sarcomas. The more rare undifferentiated endometrial sarcomas occur in postmenopausal women and most patients die in the first two years after diagnosis. Risk stratification of preoperative differential diagnosis requires improvements and the correct histopathologic workup of mesodermal uterine malignancies is still a challenge for pathologists.


Subject(s)
Uterine Neoplasms/surgery , Adenosarcoma/diagnosis , Adenosarcoma/pathology , Adenosarcoma/surgery , Carcinosarcoma/diagnosis , Carcinosarcoma/pathology , Carcinosarcoma/surgery , Endometrial Stromal Tumors/diagnosis , Endometrial Stromal Tumors/pathology , Endometrial Stromal Tumors/surgery , Endosonography , Female , Humans , Hysterectomy , Laparoscopy , Leiomyoma/diagnosis , Leiomyoma/pathology , Leiomyoma/surgery , Leiomyosarcoma/diagnosis , Leiomyosarcoma/pathology , Leiomyosarcoma/surgery , Middle Aged , Mixed Tumor, Mesodermal/diagnosis , Mixed Tumor, Mesodermal/pathology , Mixed Tumor, Mesodermal/surgery , Mixed Tumor, Mullerian/diagnosis , Mixed Tumor, Mullerian/pathology , Mixed Tumor, Mullerian/surgery , Neoplasm Staging , Peritoneal Neoplasms/pathology , Peritoneal Neoplasms/secondary , Prognosis , Ultrasonography, Doppler, Color , Uterine Neoplasms/diagnosis , Uterine Neoplasms/pathology
2.
Acta Med Croatica ; 65 Suppl 1: 229-34, 2011 Sep.
Article in Croatian | MEDLINE | ID: mdl-23126058

ABSTRACT

Malignant mixed mesodermal tumor (MMMT) of the ovary is a rare aggressive tumor that consists of an epithelial (carcinoma) and a stromal (sarcoma) component. MMMT accounts for less than 2% of ovarian cancers and has a very poor prognosis. We present a case and difficulties of diagnosing an ovarian MMMT in a postmenopausal woman with a history of invasive breast carcinoma treated postoperatively with radiotherapy and tamoxifen. A 52-year-old patient presented with unilateral ovarian tumor and moderately elevated CA125 (107 U/mL) and underwent laparotomy. Fine needle aspiration of the ovary and ascites for cytologic analysis, and tumor biopsy for histopathology were performed intraoperatively. Intraoperative cytologic sample showed necrotic background with rare single malignant cells with pale, abundant cytoplasm and conspicuous nucleoli suggesting clear cell carcinoma. Ascites sample showed inflammatory and reactive background with suspected papillary formations mimicking adenocarcinoma. Postoperatively, cytochemical PAS staining and immunocytologic staining with epithelial antigen (EA), cytokeratin (CK)7 and vimentin showed EA and PAS positivity for ovarian tumor, and EA and CK7 for ascites, suggesting a clear cell carcinoma. Histology revealed ovarian clear cell carcinoma. Three months later, the patient underwent hemicolectomy because of tumors on the right large bowel serosa with intraoperative morphological finding of metastatic malignant tumor without other specific features. Postoperative morphological analysis and immunohistochemical staining of the tumor revealed two malignant components, epithelial and stromal one. Repeat histologic analysis of the ovarian tumor confirmed ovarian MMMT (with a clear cell carcinoma component). Other studies of breast cancer emphasize that patients with invasive breast cancer and mutations of BRCA1 and BRCA2 genes are at an increased risk of primary ovarian cancer. Our study confirmed it and suggested considering a second primary malignant tumor of ovarian origin in patients with a history of breast carcinoma, postoperatively treated with radiotherapy and tamoxifen. Although rare, second primary ovarian tumors may present as MMMT.


Subject(s)
Breast Neoplasms/pathology , Mixed Tumor, Mesodermal/diagnosis , Neoplasms, Second Primary/pathology , Ovarian Neoplasms/diagnosis , Colonic Neoplasms/secondary , Female , Humans , Middle Aged , Mixed Tumor, Mesodermal/pathology , Mixed Tumor, Mesodermal/secondary , Ovarian Neoplasms/pathology
3.
Prensa méd. argent ; 98(8): 499-505, 2011. ilus
Article in Spanish | LILACS | ID: lil-665115

ABSTRACT

Los tumores mesenquimáticos de la mucosa uterina son un grupo raro, heterogéneo y generalmente agresivo de neoplasias que conduce frecuentemente a una diseminación y muerte temprana. Constituyen menos del 3% de todos los tumores malignos del Tracto Genital Femenino y el 2-7% de las neoplasias malignas uterinas. Presentamos 4 casos de tumores mesenquimáticos diagnosticados en un período de 5 años en el Servicio de Anatomía Patológica del Hospital General de Agudos Carlos G. Durand, analizando su incidencia y haciendo una breve revisión de las características histopatológicas de los mismos


Mesenchymal tumors of the uterine lining are a rare and heterogeneous group of neoplasms, with an agressive behavior leading to an early dissemination and death. They represent less than 3% of all malignant tumors of the Female Genital Tract and 2-7% of uterine malignancies. We report 4 mesenchymal tumors diagnosed throughout a 5 years period at the Department of Pathology Hospital General Carlos G. Durand, analyzing their incidence and making a review of the histopathologic features


Subject(s)
Humans , Adult , Female , Middle Aged , Adenosarcoma/pathology , Carcinosarcoma/diagnosis , Carcinosarcoma/pathology , Diagnosis, Differential , Uterine Neoplasms/surgery , Sarcoma, Endometrial Stromal/diagnosis , Mixed Tumor, Mesodermal/diagnosis
4.
An. sist. sanit. Navar ; 33(2): 217-219, mayo-ago. 2010.
Article in Spanish | IBECS | ID: ibc-88827

ABSTRACT

La hipercalcemia secundaria a enfermedad neoplásicaes una entidad frecuente causada en la mayor partede los casos por secreción ectópica de PTHrp. A pesarde esto hay ciertos tumores, como los carcinomas uterinos,en donde este tipo de manifestación paraneoplásicaestá muy poco descrita. Presentamos un caso dehipercalcemia humoral en un carcinoma mixto de endometrio (AU)


Hypercalcemia secondary to neoplastic diseaseis a frequent entity caused in the majority of cases byectopic secretions of PTHrP. Despite this there are certaintumours, such as uterine carcinomas, in which thistype of paraneoplastic manifestation has been describedvery little. We present a case of humoral hypercalcemiain a mixed endometrial carcinoma (AU)


Subject(s)
Humans , Female , Aged, 80 and over , Hypercalcemia/complications , Hypercalcemia/diagnosis , Mixed Tumor, Mesodermal/complications , Mixed Tumor, Mesodermal/diagnosis , Mixed Tumor, Malignant/complications , Paraneoplastic Endocrine Syndromes/complications , Paraneoplastic Endocrine Syndromes/diagnosis , Hysterectomy/methods , Cell Dedifferentiation/physiology , Hypercalcemia/surgery , Hypercalcemia , Mixed Tumor, Mesodermal , Cervix Uteri/pathology , Cervix Uteri , Uterine Neoplasms/complications , Uterine Neoplasms , Paraneoplastic Syndromes/complications , Lymph Node Excision
5.
Ginekol Pol ; 75(10): 793-6, 2004 Oct.
Article in Polish | MEDLINE | ID: mdl-15587911

ABSTRACT

A rare case of uterine's mixed mesodermal malignant tumor in young woman was described. Clinical symptoms, risk groups, treatment, and prognosis were presented. It was noticed that every year younger women are attacked by this kind of tumor.


Subject(s)
Mixed Tumor, Mesodermal , Uterine Neoplasms , Adult , Fatal Outcome , Female , Humans , Mixed Tumor, Mesodermal/complications , Mixed Tumor, Mesodermal/diagnosis , Mixed Tumor, Mesodermal/therapy , Time Factors , Uterine Hemorrhage/etiology , Uterine Neoplasms/complications , Uterine Neoplasms/diagnosis , Uterine Neoplasms/therapy
6.
J Reprod Med ; 47(11): 946-8, 2002 Nov.
Article in English | MEDLINE | ID: mdl-12497688

ABSTRACT

BACKGROUND: Malignant mixed mesodermal tumors (MMMTs) are uncommon, highly aggressive tumors of the uterus composed of both carcinomatous and sarcomatous elements, both likely to be derived from the same original stem cell. There is a strong association between endometrial adenocarcinoma and polycystic ovary disease. However, only two cases of MMMT occurring in women with polycystic ovaries have been reported. CASE: A 36-year-old woman with polycystic ovary disease developed an MMMT of the endometrium. CONCLUSION: Some cases of MMMT may be estrogen related.


Subject(s)
Mixed Tumor, Mesodermal/diagnosis , Polycystic Ovary Syndrome/diagnosis , Uterine Neoplasms/diagnosis , Adult , Anemia/etiology , Diagnosis, Differential , Female , Humans , Mixed Tumor, Mesodermal/complications , Mixed Tumor, Mesodermal/pathology , Mixed Tumor, Mesodermal/radiotherapy , Mixed Tumor, Mesodermal/surgery , Polycystic Ovary Syndrome/complications , Polycystic Ovary Syndrome/pathology , Polycystic Ovary Syndrome/radiotherapy , Polycystic Ovary Syndrome/surgery , Uterine Hemorrhage/etiology , Uterine Neoplasms/complications , Uterine Neoplasms/pathology , Uterine Neoplasms/radiotherapy , Uterine Neoplasms/surgery
7.
Eur Radiol ; 12(11): 2737-42, 2002 Nov.
Article in English | MEDLINE | ID: mdl-12386766

ABSTRACT

Our objective was to evaluate the usefulness of MRI including dynamic study in differentiating malignant, mixed mesodermal tumor (MMMT) from endometrial carcinoma (EC). The MR images were reviewed in 4 patients with histologically confirmed MMMT and 11 patients with EC. Flow voids inside and/or around the tumors were seen in 2 patients with MMMT but not in any EC cases. In dynamic studies, all 4 patients with MMMT showed areas of early and persistent marked enhancement similar to that of the myometrium, mixed with areas of gradual and delayed marked enhancement. The portions showing early and persistent enhancement histologically corresponded to predominantly sarcomatous components with prominent vascularity. Ten of 11 ECs did not show such enhancement and only one showed a rapid enhancement in the early phase which was diminished in the delayed phase. The MR imaging with a gadolinium-enhanced dynamic study seems to be useful in differentiating MMMT from EC.


Subject(s)
Endometrial Neoplasms/diagnosis , Magnetic Resonance Imaging , Mixed Tumor, Mesodermal/diagnosis , Uterine Neoplasms/diagnosis , Aged , Case-Control Studies , Contrast Media , Diagnosis, Differential , Female , Gadolinium DTPA , Humans , Middle Aged , Uterus/pathology
8.
Magn Reson Imaging ; 17(10): 1445-55, 1999 Dec.
Article in English | MEDLINE | ID: mdl-10609993

ABSTRACT

The objective of the study was to assess the usefulness of magnetic resonance (MR) imaging in distinguishing malignant from benign conditions in patients with an abnormal uterine cavity. Fifty-four patients that were suspected of having abnormal uterine cavities were retrospectively evaluated by using MR imaging. The diagnosis of an abnormal uterine cavity included a thickened endometrium, and/or a endometrial mass, and/or a submucosal mass. Threshold values to classify the uterine cavity as abnormal on sagittal T2-weighted images were >10 mm for premenopausal women and >5 mm for postmenopausal women. Malignancy was diagnosed when lesions invaded the myometrial/junctional zone, and/or lesion enhancement was lower than that of the adjacent myometrium. The results found that histology confirmed 18 malignant and 37 benign lesions. Twelve of 15 endometrial carcinomas and 3 malignant mixed mesodermal tumors (MMMT) were correctly characterized as malignant on enhanced T1-weighted images; whereas 6 of 15 endometrial carcinomas and 3 MMMT were correctly characterized on T2-weighted images. Thirty-four of 37 benign cases were correctly characterized as not malignant on enhanced T1-weighted images. One of 14 submucosal leiomyomas, one endometrial stromal metaplasia, and one of ten pathologically normal endometria were misdiagnosed on enhanced T1-weighted images but were correctly diagnosed on T2-weighted images. The overall sensitivity, specificity, and accuracy for distinguishing malignant from benign central uterine masses were 83%, 92%, and 89% for enhanced T1-weighted image, and 50%, 97%, and 82% for T2-weighted image, respectively. We came to the conclusion that in diagnosing patients with abnormal uterine cavity, MR imaging may help differentiate malignant from benign disorders.


Subject(s)
Carcinoma/diagnosis , Endometrial Hyperplasia/diagnosis , Endometrial Neoplasms/diagnosis , Leiomyoma/diagnosis , Magnetic Resonance Imaging , Mixed Tumor, Mesodermal/diagnosis , Uterus/pathology , Adult , Aged , Aged, 80 and over , Biopsy , Carcinoma/surgery , Curettage , Diagnosis, Differential , Endometrial Hyperplasia/surgery , Endometrial Neoplasms/surgery , Female , Humans , Hysterectomy , Leiomyoma/surgery , Metaplasia , Middle Aged , Mixed Tumor, Mesodermal/surgery , Reproducibility of Results , Retrospective Studies , Sensitivity and Specificity , Uterus/surgery
9.
Eur J Obstet Gynecol Reprod Biol ; 83(2): 191-4, 1999 Apr.
Article in English | MEDLINE | ID: mdl-10391531

ABSTRACT

The occurrence of sarcoma in a benign cystic teratoma is very rare. We report the first poorly differentiated, malignant mixed mesodermal tumor with a component of rhabdomyosarcoma to arise in a benign cystic teratoma of the ovary. The tumor was staged as FIGO IC due to capsule invasion. Although combination chemotherapy of cisplatin, ifosfamide and mesna, was instituted, the disease took a rapidly progressive course. After an unusual metastasis to the scapula was detected, the patient deteriorated and died in the forth postoperative month.


Subject(s)
Bone Neoplasms/secondary , Mixed Tumor, Mesodermal/secondary , Ovarian Neoplasms/pathology , Teratoma/secondary , Adult , Bone Neoplasms/diagnosis , Fatal Outcome , Female , Humans , Mixed Tumor, Mesodermal/diagnosis , Mixed Tumor, Mesodermal/therapy , Ovarian Neoplasms/diagnosis , Ovarian Neoplasms/therapy , Rhabdomyosarcoma , Scapula , Teratoma/diagnosis , Teratoma/therapy
10.
Eur J Obstet Gynecol Reprod Biol ; 83(2): 227-31, 1999 Apr.
Article in English | MEDLINE | ID: mdl-10391539

ABSTRACT

Extra-uterine, and especially extragenital, malignant mixed mesodermal tumors (MMMT) are very rare. A large intrapelvic tumor resected from a 56-year-old woman was investigated with morphological and immunohistochemical methods. A large, soft and fragile tumor was located in the pelvic space. The tumor showed high cellularity and was biphasic; it consisted of an admixture of adenocarcinoma and various kinds of sarcomas. The latter were comprised of high-grade endometrial stromal sarcoma, pleomorphic sarcoma, and chondrosarcoma. The pleomorphic sarcoma showed a storiform pattern. The periodic acid-Schiff-positive eosinophilic hyaline droplets and globules in multinucleated giant cells revealed a typical ring-like or peripheral staining for alpha-1-antitrypsin and alpha-1 antichymotrypsin. We considered this case to be pelvic MMMT of uncertain origin, heterologous type.


Subject(s)
Mixed Tumor, Mesodermal/pathology , Pelvic Neoplasms/pathology , Combined Modality Therapy , Female , Humans , Immunohistochemistry , Magnetic Resonance Imaging , Middle Aged , Mixed Tumor, Mesodermal/diagnosis , Mixed Tumor, Mesodermal/therapy , Pelvic Neoplasms/diagnosis , Pelvic Neoplasms/therapy , Tomography, X-Ray Computed
11.
Gynecol Obstet Invest ; 47(1): 69-72, 1999.
Article in English | MEDLINE | ID: mdl-9852395

ABSTRACT

Early diagnosis of malignant mixed mesodermal tumors of the ovary is very difficult because of the rarity and the insidious onset. The purpose of this report is to review the magnetic resonance imaging features of an ovarian malignant mixed mesodermal tumor, which occurred in a 52-year-old woman, aiding in the differential diagnosis.


Subject(s)
Mixed Tumor, Mesodermal/diagnosis , Ovarian Neoplasms/diagnosis , Chemotherapy, Adjuvant , Female , Humans , Magnetic Resonance Imaging , Middle Aged , Mixed Tumor, Mesodermal/diagnostic imaging , Mixed Tumor, Mesodermal/surgery , Ovarian Neoplasms/diagnostic imaging , Ovarian Neoplasms/surgery , Ultrasonography
12.
Surg Today ; 27(7): 653-6, 1997.
Article in English | MEDLINE | ID: mdl-9306570

ABSTRACT

We herein report the case of a 69-year old woman presenting with an abdominal mass, who was found to have a mixed mesodermal tumor (MMT) of the cecum. Imaging studies and endoscopic investigations were consistent with the diagnosis of a nonepithelial malignant tumor of the cecum. On laparotomy, a knuckle-sized firm mass involving the cecum was noticed. As a result, a right hemicolectomy was performed. Pathological examinations, including immunohistochemical staining, resulted in the diagnosis of mesodermal mixed tumor, homologous type. The patient was advised to undergo postoperative chemotherapy but she did not comply. She has been followed up as an outpatient and is still alive 1.5 years after the operation.


Subject(s)
Cecal Neoplasms/pathology , Mixed Tumor, Mesodermal/pathology , Aged , Cecal Neoplasms/diagnosis , Cecal Neoplasms/metabolism , Cecal Neoplasms/surgery , Colectomy , Female , Humans , Immunochemistry , Lymphatic Metastasis , Magnetic Resonance Imaging , Mixed Tumor, Mesodermal/diagnosis , Mixed Tumor, Mesodermal/metabolism , Mixed Tumor, Mesodermal/surgery
13.
J. bras. ginecol ; 99(1/2): 33-5, jan.-fev. 1989. ilus
Article in Portuguese | LILACS | ID: lil-199985

ABSTRACT

É descrito um caso raro de sarcoma mesodérmico ou mülleriano misto maligno do ovário. Säo tecidas consideraçöes quanto à incidência, histogênese, anatomia patológica, quadro clínico, vias de propagaçäo e tratamento. O prognóstico é reservado, com baixos índices de sobrevida


Subject(s)
Humans , Female , Middle Aged , Ovarian Neoplasms/diagnosis , Mixed Tumor, Mesodermal/diagnosis , Ovarian Neoplasms/pathology , Ovarian Neoplasms/surgery , Mixed Tumor, Mesodermal/surgery , Mixed Tumor, Mesodermal/pathology
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