The evolution of the micrographic surgery and dermatologic oncology fellowship.

During its brief history, the Micrographic Surgery and Dermatologic Oncology (MSDO) fellowship has undergone notable changes in scope, recognition, popularity amongst residents, the match process, and associated subspecialty board certification, attesting to the fellowship's adaptability over time.

Frederic E. Mohs, MD, and the history of zinc chloride.

The history of zinc chloride therapy before and including Frederic E. Mohs' (1910-2002) early contributions to dermatologic oncology is presented. In 1932, Mohs devised a method of cutaneous surgery that employed zinc-chloride paste to devitalize basal or squamous cell carcinoma. Because zinc chloride coagulates malignant tissue without destroying cellular architecture, he described the surgery and its preservative effect as the fixed-tissue method. This method involved the serial removal of devitalized malignant tissue and the freezing and histologic examination of each layer; the process was continued until a cancer-free plane was reached. In 1953, a modified version of the micrographic system, the fresh-tissue method, was introduced. For improved efficiency, Mohs retained the systematic mapping of a neoplasm but eliminated the chemical escharotic. Although the fresh-tissue method has become the preferred treatment mode, zinc-chloride paste therapy remains in use today. Although the history of Mohs micrographic surgery is well documented, its background has not received sufficient attention. This paper surveys the chemical synthesis of zinc chloride, the formulation of zinc-chloride paste as a cutaneous escharotic, and the extent to which Mohs' method compares with those of 19th and early 20th century predecessors.

How Mohs Surgery Transformed Into a First-Line Treatment of Skin Cancer.

Mohs surgery is considered ideal treatment for many types of skin cancers. Developed by Dr Frederic Edward Mohs (1910-2002), Mohs surgery allows all surgical margins to be viewed microscopically, ensuring no cancer cells go unremoved, yet it failed to achieve immediate acceptance when first introduced in the 1940s. A catalyst to the widespread acceptance of Mohs surgery occurred with the work of dermatologic colleagues who reported excellent results without using the paste. It suggested the real innovation of Mohs surgery lay in its microscopic control and not the paste, the discontinuation of which removed all the problems associated with its use.

Mohs micrographic surgery: history, technique, and advancements.

Mohs micrographic surgery is an excision technique that has been widely adapted as the recommended treatment for basal and squamous cell carcinomas and other skin cancers. It was developed by Frederic E. Mohs in the 1930s and has since advanced in its methods and applications. Mohs developed the practice in the process of determining a method to treat various neoplasms. Mohs micrographic surgery is a modality that involves serial excision of a tumor followed by microscopic evaluation of the tissue. It is a complicated surgical technique that involves scrupulous training and constant adaptation. It has greatly expanded since its inception to include new imaging techniques such as immunohistochemistry and confocal mosaicing microscopy. Further advancements include its application to other medical specialties, such as otolaryngology. This technique began as a revolutionary practice but has since become the standard treatment for a variety of skin cancers.

Cirurgia micrográfica de Mohs / Mohs micrographic surgery

A cirurgia de Mohs foi primeiramente descrita por Frederic Mohs para eliminar os tumores de pele de alto risco. Com a técnica de Mohs os médicos conseguem enxergar além da lesão visível, para identificar com precisão e remover todo o tumor, camada por camada, enquanto deixa a pele não comprometida ao redor intacta e sem danos. Com um método mais preciso e seguro de remoção de tumor se minimiza a chance de recrescimento e diminui o potencial de cicatrização inestética e desfigurante.

History of Mohs surgery.

Mohs micrographic surgery (MMS) has become the gold standard for treating many forms of primary and recurrent contiguous skin cancers and offers the highest cure rates and maximum tissue conservation compared with other modalities. Developed by Dr Frederic E. Mohs in the 1930s, it was initially called chemosurgery and used zinc chloride paste in a process called fixed tissue technique. Although this technique had high cure rates, it could take days to complete, and it gradually gave way to fresh tissue technique, renamed MMS. Now, MMS is practiced widely as part of a multidisciplinary approach for treating skin cancer.

Mohs surgery revisited: 25 key articles.

It has been over 30 years since Dr. Mohs first realized the potential for the surgery that now bears his name, and since then hundreds of articles have been published in dozens of Journals regarding his research and clinical experience, and the work of those who followed him. Collated in his memory by Drs. David Goldberg and C. William Hanke, and Ronald Moy, these 25 articles are meant to represent a cross-section of the most important articles ever published on the subject of Mohs surgery, and provide an excellent resource for those interested in learning about its development and refinement over the years.

Mohs micrographic surgery.

Mohs micrographic surgery (MMS) is a specialized type of minimal marginal surgery that offers cure rates superior to other options in the treatment of contiguous skin cancers in selected settings. Developed by Dr. Frederic E. Mohs, the technique originally required in situ tissue fixation before excision. Most Mohs micrographic surgeons now use the fresh tissue technique exclusively. Horizontal frozen histologic sections of the excised tumor permit more complete microscopic examination of the surgical margin than traditional methods. Residual tumor is graphically mapped and malignant extensions are pursued with staged excisions until the tumor is removed. Maximum sparing of tumor-free adjacent tissue is achieved with histologic mapping of the tumor boundaries, thus optimizing subsequent wound reconstruction. The history, techniques, indications, cure rates, and current controversies of MMS are reviewed.