ABSTRACT
No disponible
Subject(s)
Humans , Male , Adolescent , Nails, Malformed/chemically induced , Nail Diseases/chemically induced , Prenatal Exposure Delayed Effects/chemically induced , Phenytoin/adverse effects , Nails, Malformed/complications , Hand Deformities, Congenital/diagnostic imaging , Hand Deformities, Congenital/pathology , Foot Deformities, Congenital/diagnostic imaging , Foot Deformities, Congenital/pathology , Fetal Monitoring , Pregnancy/drug effectsSubject(s)
Antineoplastic Combined Chemotherapy Protocols/adverse effects , Lymphoma, T-Cell/drug therapy , Nails, Malformed/chemically induced , Cyclophosphamide/adverse effects , Doxorubicin/adverse effects , Etoposide/adverse effects , Female , Humans , Middle Aged , Nails/drug effects , Prednisolone/adverse effects , Vincristine/adverse effectsABSTRACT
BACKGROUND: Nail changes due to systemic drugs are common, especially with anticancer treatments due to involvement of nail plate, nail bed and periungual area. OBJECTIVE: To study the pattern of nail changes occurring due to chemotherapy in patients suffering from various malignancies. MATERIALS AND METHODS: A prospective, observational study was conducted at various health care centres, Nashik, India, for 15 months. The timing of administration of chemotherapy and onset of nail changes were recorded and evaluated by a dermatologist at regular interval. RESULTS: A total of 129 diagnosed cases of various malignancies who received chemotherapy were included. The most common malignancy noted was breast cancer, that is n = 42 (32.5%) followed by oral cancer, that is n = 24 (18.6%). Chemotherapy agents included taxanes (n = 54), cyclophosphamide (n = 42) and prednisolone (n = 28). Nail changes were noted in 92 patients (71.3%). The most common nail changes observed were chromonychia (n = 70, 54.26%), followed by nail dystrophy (n = 38, 29.45%). CONCLUSION: Nail toxicity is quite common side effect of anticancer agents. Nail changes due to chemotherapy depend on the nail structure involved and the severity of insult. Awareness among dermatologists and oncologists of these nail changes and their culprit agent can promote early diagnosis and may avoid inadvertent measures.
Subject(s)
Antineoplastic Agents/adverse effects , Nail Diseases/chemically induced , Nails, Malformed/chemically induced , Neoplasms/drug therapy , Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Prospective StudiesSubject(s)
Hydroxychloroquine/adverse effects , Mixed Connective Tissue Disease/drug therapy , Nail Diseases/chemically induced , Nails, Malformed/chemically induced , Nails, Malformed/diagnosis , Arthritis/drug therapy , Arthritis/etiology , Diagnosis, Differential , Female , Humans , Hydroxychloroquine/therapeutic use , Middle Aged , Mixed Connective Tissue Disease/complications , Nail Diseases/diagnosis , Nails, Malformed/etiology , Raynaud Disease/drug therapy , Raynaud Disease/etiologySubject(s)
Acro-Osteolysis/congenital , Analgesics, Opioid/adverse effects , Nails, Malformed/congenital , Nails , Prenatal Exposure Delayed Effects/diagnosis , Prostheses and Implants , Acro-Osteolysis/chemically induced , Acro-Osteolysis/diagnosis , Acro-Osteolysis/psychology , Adolescent , Esthetics , Female , Genetic Testing , Humans , Male , Mutation , Nails, Malformed/chemically induced , Nails, Malformed/diagnosis , Nails, Malformed/psychology , Patient Satisfaction , Pregnancy , Quality of Life , ThrombospondinsSubject(s)
Antineoplastic Agents/adverse effects , Imatinib Mesylate/adverse effects , Melanosis/chemically induced , Nail Diseases/chemically induced , Nails, Malformed/chemically induced , Protein Kinase Inhibitors/adverse effects , Aged, 80 and over , Antineoplastic Agents/therapeutic use , Humans , Imatinib Mesylate/therapeutic use , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy , Male , Melanosis/diagnosis , Nail Diseases/diagnosis , Nails, Malformed/diagnosis , Protein Kinase Inhibitors/therapeutic useABSTRACT
INTRODUCTION: Carbon monoxide poisoning is a very common cause of death in accidental, suicidal, or homicidal cases throughout the world. Fingernail bed manifestation is reported in survivors of carbon monoxide poisoning. CASE PRESENTATION: A 40-year-old Caucasian woman was exposed to carbon monoxide when she was sleeping alone in her one-bedroom apartment; fortunately, the beeps from her First Alert combination smoke and carbon monoxide detector woke her and she was saved from any extensive health issues. The most indicative symptoms experienced were a severe headache, blurred vision, agitation, and confusion. Following contact with the Emergency Responses Services, she was promptly transferred to the hospital via ambulance and was treated with high-flow oxygen on the way. She was discharged from the emergency department on the same day, but carbon monoxide exposure had already had adverse effects on her fingernail beds. The fingernail tips were altered and appeared as if a bite had been taken out of their distal borders. The changes in the tips of her fingernails were significant, but they completely disappeared eight weeks later without any additional treatment. CONCLUSIONS: Worldwide, carbon monoxide poisoning is a potentially lethal condition that is preventable with educational programs and installation of carbon monoxide detectors in the home setting. Exposure to carbon monoxide frequently goes unrecognized until it is too late and causes silent death. To the best of the authors' knowledge, this is the first report in the literature of fingernail bed manifestations in a survivor of carbon monoxide poisoning.
Subject(s)
Carbon Monoxide Poisoning/therapy , Nails, Malformed/chemically induced , Nails, Malformed/therapy , Nails/drug effects , Oxygen Inhalation Therapy/methods , Adult , Emergency Medical Services/methods , Female , Humans , Treatment OutcomeSubject(s)
Dermatologic Agents/adverse effects , Eczema/drug therapy , Foot Dermatoses/drug therapy , Hand Dermatoses/drug therapy , Nail Diseases/chemically induced , Nails, Malformed/chemically induced , Tretinoin/adverse effects , Alitretinoin , Chronic Disease , Cyclosporine/therapeutic use , Drug Substitution , Eczema/diagnosis , Foot Dermatoses/diagnosis , Hand Dermatoses/diagnosis , Humans , Male , Middle Aged , Nail Diseases/diagnosis , Nails, Malformed/diagnosis , Time Factors , Treatment OutcomeSubject(s)
Nails, Malformed/diagnosis , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Cisplatin/administration & dosage , Cisplatin/adverse effects , Diagnosis, Differential , Esophagogastric Junction , Fluorouracil/administration & dosage , Fluorouracil/adverse effects , Humans , Male , Middle Aged , Nails, Malformed/chemically induced , Stomach Neoplasms/drug therapySubject(s)
Antineoplastic Agents/adverse effects , Lung Neoplasms/drug therapy , Nails, Malformed/chemically induced , Nails/drug effects , Taxoids/adverse effects , Antineoplastic Agents/therapeutic use , Cisplatin/therapeutic use , Deoxycytidine/analogs & derivatives , Deoxycytidine/therapeutic use , Docetaxel , Female , Humans , Lung Neoplasms/radiotherapy , Lung Neoplasms/secondary , Middle Aged , Nails, Malformed/diagnosis , Taxoids/therapeutic use , GemcitabineABSTRACT
A 39-year-old man with human immunodeficiency virus infection and Kaposi sarcoma on HAART therapy and doxorubicin presented in 2007 with a hyperpigmented tongue. Physical examination also showed hyperpigmented patches on the mucosal aspects of the lips and longitudinal dark bands on multiple nails. A skin biopsy specimen showed pigmentary alteration. Such hyperpigmentation has been described in numerous case reports and case series and has been reported to resolve within weeks to months of cessation of doxorubicin.
