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1.
Beijing Da Xue Xue Bao Yi Xue Ban ; 56(2): 293-298, 2024 Apr 18.
Article in Chinese | MEDLINE | ID: mdl-38595247

ABSTRACT

OBJECTIVE: The pain-relieving effect and safety of compound aminopyrine phenacetin tablets, tramcontin (tramadol hydrochloride sustained-release tablets) and dolantin in the early stage of autologous tendon reconstruction of the anterior cruciate ligament (ACL) of the knee joint were compared. METHODS: Retrospective analysis of postoperative pain and drug analgesia in 45 patients performed by the same group from November 2018 to February 2019. The random area group design was divided into two groups according to whether ACL rupture was combined with meniscal injury, group A was 24 patients with ACL reconstruction of knee joint and group B was 21 patients with ACL fracture combined with meniscus injury. The two groups were divided into three subgroups respectively according to the actual treatment of postoperative analgesic drugs received by the patients, including 4 cases of compound aminopyrine phenacetin tablets, 11 cases of oral tramcontin, 9 cases of intramuscular dolantin combined with phenergan in group A; 3 cases of compound aminopyrine phenacetin tablets, 10 cases of oral tramcontin, and 8 cases of intramuscular dolantin combined with phenergan in group B. When the early postoperative patients complain about pain and actively ask for analgesia. When the patients complained about pain after the operation and actively asked for analgesia, they were randomly given painkillers, tramcontin or dolantin combined with phenergan to relieve pain. Pain visual analogue scale (VAS) was used to evaluate pain relief and observe the occurrence of adverse reactions. RESULTS: There were no significant dif-ferences in gender, age, body mass index, and time of hospital stay between the two groups of patients (P > 0.05). In the patients who used tramcontin and dolantin combined with phenergan to relieve pain judging by VAS score before and 1 h after taking the drug, it was found that the pain situation of the patient was significantly relieved, and the difference before and after taking the drug had statistical significance (P < 0.05). Pairwise comparisons of the three drugs applied in the two groups showed significantly greater pain relief in the dolantin combined with phenergan group than in the remaining two drugs. There was no significant difference (P > 0.05). Dolantin was prone to nausea and vomiting, but the application of phenergan was also used to reduce side effects. In terms of adverse reactions, only 1 case of nausea occurred in the tramcontin group for simple ACL reconstruction, and none of the patients in the other groups showed serious complications and allergic reactions. CONCLUSION: Whether in cruciate ligament reconstruction alone or combined with meniscus molding or suture, compound aminopyrine phenacetin tablets, tramcontin, dolantin combined with phenergan can effectively relieve pain. Among the three drugs, dolantin caused the largest pain relief. At the same time, the combination of phenergan effectively reduced the adverse reactions, such as vomiting and nausea, and increased the drug safety.


Subject(s)
Anterior Cruciate Ligament Injuries , Anterior Cruciate Ligament Reconstruction , Humans , Aminopyrine , Analgesics , Anterior Cruciate Ligament Injuries/surgery , Knee Joint/surgery , Meperidine , Nausea/surgery , Pain, Postoperative/drug therapy , Phenacetin , Promethazine , Retrospective Studies , Treatment Outcome , Vomiting/surgery
2.
Colorectal Dis ; 25(12): 2306-2316, 2023 Dec.
Article in English | MEDLINE | ID: mdl-37880879

ABSTRACT

AIM: Rectal cancer is often treated surgically with an anterior resection (AR) or abdominoperineal excision (APE). However, for patients with locally advanced disease or local recurrence total pelvic exenteration (TPE) surgery can be performed. The magnitude of surgery varies, and little research has been done to consider how quality of life (QoL) may vary according to the extent of surgery. METHOD: A search was conducted on MEDLINE and PubMed for papers published from 2010 to 2021. Inclusion criteria consisted of observational studies comparing adult populations with rectal cancer undergoing APE, AR or TPE, reporting QoL using validated tools. Risk of bias was assessed using the Risk of Bias in Non-Randomized Studies of Interventions (ROBINS-I) tool. Outcomes of interest were global QoL, gastrointestinal (GI) symptoms (nausea and vomiting, diarrhoea, and constipation) and pain. RESULTS: Seven studies including 1402 patients were analysed. QoL following TPE generally improves over time, back to baseline or better. AR and APE groups have similar patterns of improvement between baseline and 12 months after surgery, although scores declined in some studies at 12 months. TPE scores are lower overall, and the pattern of improvement differs, with patients tending to have worse nausea and vomiting symptoms. AR and APE patients tend to experience more lower GI symptoms. CONCLUSION: It is not possible to draw firm conclusions based on the studies analysed. However, QoL returns to baseline following TPE, APE and AR. Preoperative QoL appears to be an indication of postoperative outcomes. Further observational studies are required.


Subject(s)
Hominidae , Pelvic Exenteration , Rectal Neoplasms , Adult , Humans , Animals , Quality of Life , Rectal Neoplasms/surgery , Vomiting , Nausea/surgery
3.
Obes Surg ; 33(8): 2317-2323, 2023 08.
Article in English | MEDLINE | ID: mdl-37347399

ABSTRACT

INTRODUCTION: Same-day discharge (SDD) after bariatric surgery is increasingly being performed and is safe with careful patient selection. However, detecting early complications during the first postoperative days can be challenging. We developed a postoperative care protocol for these patients and aimed to evaluate its effectiveness in detecting complications and monitoring patient recovery. METHODS: A single-center retrospective observational study was conducted with patients with who underwent Roux-en-Y Gastric Bypass (RYGB) with successful SDD. The study evaluated the effectiveness of the safety net that included simple remote monitoring with a pulsoximeter and thermometer, a phone consultation on postoperative day (POD) 1, and a physical consultation on POD 2-4. Furthermore, an analysis was performed on various factors including pain scores, painkiller usage, and incidences of nausea and vomiting on POD 1. RESULTS: In this study, 373 consecutive patients were included, of whom 19 (5.1%) were readmitted until POD 4. Among these, 12 patients (3.2%) reached out to the hospital themselves, while 7 (1.9%) were readmitted after phone or physical consultations. Ten of the readmitted patients had tachycardia. On POD 1, the mean numeric rating scale was 4 ± 2, and 96.6% of the patients used acetaminophen, 35.5% used naproxen, and 9.7% used oxynorm. Of the patients, 13.9% experienced nausea and 6.7% reported vomiting. CONCLUSION: A postoperative care protocol for SDD after RYGB, comprising simple remote monitoring along with a phone consultation on POD 1 and a physical checkup on POD 2-4, was effective in monitoring patient recovery and detecting all early complications.


Subject(s)
Gastric Bypass , Obesity, Morbid , Humans , Gastric Bypass/adverse effects , Gastric Bypass/methods , Nausea/surgery , Obesity, Morbid/surgery , Observational Studies as Topic , Patient Discharge , Postoperative Care , Postoperative Complications/epidemiology , Retrospective Studies , Vomiting
4.
Acta Anaesthesiol Scand ; 67(2): 221-229, 2023 02.
Article in English | MEDLINE | ID: mdl-36267030

ABSTRACT

BACKGROUND: Both the transversus abdominis plane (TAP) block and the anterior quadratus lumborum block (QLB) have been shown effective in reducing postoperative pain after laparoscopic inguinal hernia repair. Our hypothesis was that there is no difference in analgesic effect between the two blocks for this procedure. METHODS: In this prospective, double-blind, randomised controlled study, 60 adult patients undergoing laparoscopic inguinal hernia repair were equally randomly assigned to either a preoperative TAP block or an anterior QLB. The primary outcome was oral morphine equivalent (OME) consumption at 4 h postoperatively. Secondary outcomes were OME consumption at 24, 48 h and 7 days, pain scores at rest and when coughing, nausea, and level of sedation measured at 1, 2, 3, 24, and 48 h and 7 days postoperatively. RESULTS: Fifty-three patients completed the study. There was no significant difference in OME consumption at 4 h postoperatively, TAP group (10.3 ± 7.85 mg) (mean ± SD) versus the anterior QLB group (10.9 ± 10.85 mg) (p = .713). The pain scores were similar at rest and when coughing during the 7 day observation period, as were the level of sedation and incidence of nausea. There were no cases of serious side-effects or muscle weakness of the thigh on the same side as the block. CONCLUSION: There is no difference in OME consumption, pain, nausea or sedation between the TAP and the anterior QLB. Thus, the choice between the two blocks in a clinical setting of laparoscopic inguinal hernia repair should be based on other aspects, such as skills, practicalities, and potential risks.


Subject(s)
Hernia, Inguinal , Laparoscopy , Adult , Humans , Hernia, Inguinal/surgery , Prospective Studies , Pain, Postoperative/prevention & control , Morphine , Nausea/surgery , Abdominal Muscles , Laparoscopy/methods , Anesthetics, Local , Analgesics, Opioid
5.
J Am Coll Surg ; 235(1): 86-98, 2022 07 01.
Article in English | MEDLINE | ID: mdl-35703966

ABSTRACT

BACKGROUND: Laparoscopic hiatal hernia repair is commonly performed with a 1 to 2 night hospitalization. Our aim was to compare the feasibility and short-term outcomes of same-day surgery (SDS) laparoscopic hiatal hernia repair with an opioid-based anesthesia protocol (OBAP) vs an opioid-free anesthesia protocol (OFAP). STUDY DESIGN: Outcomes and pharmacy costs of repairs with OBAP were compared with OFAP. Values were expressed as median (interquartile range) and costs as means. RESULTS: There were 244 primary laparoscopic repairs. OBAP was used in 191 of 244 (78.3%) vs OFAP in 53 of 244 (21.7%). The length of stay was 1 day (0 to 2) vs 0 days (0 to 1), p = 0.006. There was no difference between the percentage of patients requiring analgesics and dosage between the 2 groups. SDS was planned in 157 and performed in 74 of 122 (60.7%) vs 33 of 35 (94.3%), p < 0.001. The age was 56 years (45 to 63) vs 60 years (56 to 68), p = 0.025. There were more type I hiatal hernia in SDS-OBAP and more type III and IV in SDS-OFAP, p = 0.031. American Society of Anesthesiologists Physical Status was II (II-III) vs III (II-III), p = 0.045. SDS was not performed in 50 of 157 (31.8%), 48 of 122 (39.3%) vs 2 of 35 (5.7%), p < 0.001. Out of 157 planned SDS, nausea/retching were causes of transition in 19 of 122 (15.6%) vs 0 of 35 (0%), p = 0.020. Multivariable logistic regression showed the odds of SDS were 8.21 times (95% CI 3.10 to 21.71; p < 0.001) greater in OFAP compared with OBAP, adjusting for sex, age, body mass index, American Society of Anesthesiologists Physical Status, type of hiatal hernia, type of procedure, and duration of the operation. Patients with opioid medication after SDS discharge were 74 of 74 (100%) vs 22 of 33 (66.7%), p < 0.001. CONCLUSIONS: Opioid-free anesthesia increases the feasibility of SDS hiatal hernia repair with less perioperative nausea and comparable pain control and pharmacy cost.


Subject(s)
Anesthesia , Hernia, Hiatal , Laparoscopy , Ambulatory Surgical Procedures , Analgesics, Opioid/therapeutic use , Hernia, Hiatal/surgery , Herniorrhaphy/methods , Humans , Laparoscopy/methods , Middle Aged , Nausea/surgery , Treatment Outcome
6.
BMJ Case Rep ; 12(6)2019 Jun 11.
Article in English | MEDLINE | ID: mdl-31189546

ABSTRACT

A 55-year-old woman developed a postoperative ileus with associated nausea and vomiting following an elective laparotomy. A wide bore nasogastric (NG) tube was inserted for gastric decompression and symptom relief. Aspiration of the tube was unsuccessful and the patient continued to vomit. Imaging to investigate the acute abdomen demonstrated the nasogastric tube to be correctly sited and within pooled gastric contents. Gentle initial attempts were made to unblock the NG but to no avail and therefore it was removed. On inspection it was discovered that the NG tube had no distal perforations to allow drainage, causing failure and increasing the patient's risk of aspiration. The aim of this report is draw attention to the importance of scrutinising all medical equipment prior to use to prevent avoidable and potentially serious patient harm.


Subject(s)
Decompression, Surgical/methods , Enteral Nutrition/adverse effects , Ileus/surgery , Intubation, Gastrointestinal/instrumentation , Postoperative Complications/surgery , Female , Humans , Ileus/etiology , Laparotomy/adverse effects , Middle Aged , Nausea/etiology , Nausea/surgery , Postoperative Complications/etiology , Prosthesis Failure , Vomiting/etiology , Vomiting/surgery
7.
PM R ; 11(4): 440-445, 2019 04.
Article in English | MEDLINE | ID: mdl-30779866

ABSTRACT

Individuals with spinal cord injury (SCI) have altered neurophysiology and present with symptoms that must be interpreted in the context of their specific neurologic injury. This is a case of a 16-year-old female adolescent with C5 American Spinal Injury Association Impairment Scale A SCI who presented with intractable nausea. Multiple etiologies for her nausea, including medication effect, metabolic and gastrointestinal disorders, autonomic dysreflexia, and mood disorder, were systematically ruled out. Due to the persistence of the patient's symptoms and suboptimal progression in her rehabilitation, a central nervous system etiology was investigated. Ultimately, atlantoaxial instability with odontoid compression on the medulla was identified and her refractory nausea resolved following an occiput to C2 fusion. To our knowledge, this is the first reported case of atlantoaxial instability causing intractable nausea due to brain stem compression in a patient with SCI. Level of Evidence: V.


Subject(s)
Atlanto-Axial Joint/physiopathology , Joint Instability/physiopathology , Medulla Oblongata/physiopathology , Nausea/physiopathology , Odontoid Process/physiopathology , Adolescent , Cervical Vertebrae/injuries , Decompression, Surgical , Female , Humans , Medulla Oblongata/diagnostic imaging , Medulla Oblongata/surgery , Nausea/surgery , Odontoid Process/diagnostic imaging , Odontoid Process/surgery , Spinal Cord Injuries/physiopathology , Tomography, X-Ray Computed
8.
F1000Res ; 7: 960, 2018.
Article in English | MEDLINE | ID: mdl-30345024

ABSTRACT

Background: Bronchogenic cysts are congenital malformations from abnormal budding of embryonic foregut and tracheobronchial tree. We present a case of bronchogenic cyst with severe back pain, epigastric distress and refractory nausea and vomiting.   Case Presentation: A 44-year-old Hispanic female presented with a 3-week history of recurrent sharp interscapular pain radiating to epigastrium with refractory nausea and vomiting. She underwent cholecystectomy 2-years ago. Computed tomography (CT) abdomen at that time showed a subcarinal mass measuring 5.4 X 5.0 cm. Subsequent endoscopic ultrasound diagnosed it as a bronchogenic cyst. Endobronchial ultrasound (EBUS) guided aspiration resulted in incomplete drainage and she was discharged after partial improvement. Current physical examination showed tachycardia and tachypnea with labs showing leukocytosis, elevated inflammatory markers, and hypokalemic metabolic alkalosis. CT chest showed an increased size of the bronchogenic cyst (9.64 X 7.7 cm) suggestive of possible partial cyst rupture or infected cyst. X-ray esophagram ruled out esophageal compression or contrast extravasation. Patient's symptoms were refractory to conservative management. The patient ultimately underwent right thoracotomy with cyst excision that resulted in complete resolution of symptoms. Conclusion: Bronchogenic cysts are the most common primary cysts of mediastinum with the prevalence of 6%. The most common symptoms are chest pain, dyspnea, cough, and stridor. Diagnosis is made by chest X-Ray and CT chest. Magnetic resonance imaging chest and EBUS are more sensitive and specific. Symptomatic cysts should be resected unless surgical risks are high. Asymptomatic cysts in younger patients should be removed due to low surgical risk and potential late complications. Watchful waiting has been recommended for asymptomatic adults or high-risk patients. This case presents mediastinal bronchogenic cyst as a cause of back, nausea and refractory vomiting. Immediate surgical excision in such cases should be attempted, which will lead to resolution of symptoms and avoidance of complications.


Subject(s)
Back Pain , Bronchogenic Cyst , Dyspepsia , Mediastinal Cyst , Nausea , Tomography, X-Ray Computed , Adult , Back Pain/diagnostic imaging , Back Pain/physiopathology , Back Pain/surgery , Bronchogenic Cyst/diagnostic imaging , Bronchogenic Cyst/physiopathology , Bronchogenic Cyst/surgery , Dyspepsia/diagnostic imaging , Dyspepsia/physiopathology , Dyspepsia/surgery , Female , Humans , Mediastinal Cyst/diagnostic imaging , Mediastinal Cyst/physiopathology , Mediastinal Cyst/surgery , Nausea/diagnostic imaging , Nausea/physiopathology , Nausea/surgery
9.
World Neurosurg ; 112: e608-e616, 2018 Apr.
Article in English | MEDLINE | ID: mdl-29374608

ABSTRACT

OBJECTIVE: To retrospectively analyze the clinical data of 6 patients with foramen magnum (FM) neurenteric (NE) cysts, and summarize the clinical characteristics and treatment experience for this rare disease in our single center. METHODS: Between January 2011 and December 2015, 6 patients with FM NE cyst were surgically treated at Xuan Wu Hospital of Capital Medical University. We summarize the treatment experience of these patients through a retrospective review of the clinical information, imaging features, surgical details, and follow-up outcomes. RESULTS: All 6 patients were female, ranging in age from 15 to 54 years (mean age, 36.8 ± 12.9 years). Occipital headache along with cranial nerve injury were the most common symptoms. Preoperative brain magnetic resonance imaging identified all lesions in the FM region, with an oblong or lobulated shape. The surgical approach was far lateral in 4 patients and suboccipital midline in 2 patients. Total lesion removal was completed in 4 patients, and subtotal excision was performed in the other 2 patients, in whom the cyst wall was intensely adherent to surrounding structures. In all 6 patients, the preoperative symptoms were significantly relieved after surgery. No recurrence was seen after a mean follow-up of 27.3 months (range, 3-70 months). CONCLUSIONS: Our present study identified a female predominance among patients with intracranial FM NE cyst. Surgical excision is the optimum treatment strategy for this rare disease. Our findings indicate that subtotal removal of an FM NE cyst may be associated with favorable outcomes, but strict long-term follow up is needed.


Subject(s)
Cranial Nerve Diseases/surgery , Foramen Magnum/surgery , Headache/surgery , Nausea/surgery , Neural Tube Defects/surgery , Neurosurgical Procedures , Adolescent , Adult , Cranial Nerve Diseases/etiology , Female , Headache/etiology , Humans , Middle Aged , Nausea/etiology , Neural Tube Defects/complications , Neural Tube Defects/diagnosis , Treatment Outcome
10.
World J Gastroenterol ; 23(24): 4467-4472, 2017 Jun 28.
Article in English | MEDLINE | ID: mdl-28706431

ABSTRACT

Primary pancreatic lymphoma (PPL) is an extremely rare form of extranodal malignant lymphoma. The most common histological subtype of PPL is diffuse large B cell lymphoma (DLBCL). In rare cases, PPL can also present as follicular lymphoma, small lymphocytic lymphoma, and T cell lymphoma either of non-Hodgkin's lymphoma or of Hodgkin's lymphoma. T-cell/histiocyte-rich large B-cell lymphoma (T/HRBCL) is an uncommon morphologic variant of DLBCL with aggressive clinical course, it is predominantly a nodal disease, but extranodal sites such as bone marrow, liver, and spleen can be involved. Pancreatic involvement of T/HRBCL was not presented before. Herein, we report a 48-year-old male who was hospitalized with complaints of jaundice, dark brown urine, pale stools, and nausea. The radiological evaluation revealed a pancreatic head mass and, following operative biopsy, the tumor was diagnosed as T/HRBCL. The patient achieved remission after six cycles of CHOP chemotherapy. Therefore, T/HRBCL can be treated similarly to the stage-matched DLBCL and both of them get equivalent outcomes after chemotherapy.


Subject(s)
Histiocytes/pathology , Lymphoma, Large B-Cell, Diffuse/diagnosis , Lymphoma, Large B-Cell, Diffuse/therapy , Pancreatic Neoplasms/diagnosis , Pancreatic Neoplasms/therapy , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Bile Ducts/diagnostic imaging , Bile Ducts/surgery , Biopsy , Chemotherapy, Adjuvant/methods , Cholangiopancreatography, Endoscopic Retrograde , Choledochostomy , Cyclophosphamide/therapeutic use , Diagnosis, Differential , Doxorubicin/therapeutic use , Gastroenterostomy , Hodgkin Disease/diagnosis , Humans , Jaundice/etiology , Jaundice/surgery , Jejunum/surgery , Liver Function Tests , Lymph Nodes/pathology , Lymphatic Metastasis , Lymphoma, Large B-Cell, Diffuse/complications , Lymphoma, Large B-Cell, Diffuse/pathology , Male , Mesentery/pathology , Middle Aged , Nausea/etiology , Nausea/surgery , Pancreas/diagnostic imaging , Pancreas/pathology , Pancreatic Neoplasms/complications , Pancreatic Neoplasms/pathology , Pancreatitis/diagnosis , Prednisone/therapeutic use , Stomach/surgery , Tomography, X-Ray Computed , Vincristine/therapeutic use
11.
Surg Obes Relat Dis ; 13(9): 1501-1505, 2017 Sep.
Article in English | MEDLINE | ID: mdl-28552743

ABSTRACT

BACKGROUND: "Candy cane" syndrome (a blind afferent Roux limb at the gastrojejunostomy) has been implicated as a cause of abdominal pain, nausea, and emesis after Roux-n-Y gastric bypass (RYGB) but remains poorly described. OBJECTIVES: To report that "candy cane" syndrome is real and can be treated effectively with revisional bariatric surgery SETTING: All patients underwent "candy cane" resection at University Hospitals of Cleveland. METHODS: All patients who underwent resection of the "candy cane" between January 2011 and July 2015 were included. All had preoperative workup to identify "candy cane" syndrome. Demographic data; pre-, peri-, and postoperative symptoms; data regarding hospitalization; and postoperative weight loss were assessed through retrospective chart review. Data were analyzed using Student's t test and χ2 analysis where appropriate. RESULTS: Nineteen patients had resection of the "candy cane" (94% female, mean age 50±11 yr), within 3 to 11 years after initial RYGB. Primary presenting symptoms were epigastric abdominal pain (68%) and nausea/vomiting (32%), particularly with fibrous foods and meats. On upper gastrointestinal study and endoscopy, the afferent blind limb was the most direct outlet from the gastrojejunostomy. Only patients with these preoperative findings were deemed to have "candy cane" syndrome. Eighteen (94%) cases were completed laparoscopically. Length of the "candy cane" ranged from 3 to 22 cm. Median length of stay was 1 day. After resection, 18 (94%) patients had complete resolution of their symptoms (P<.001). Mean body mass index decreased from 33.9±6.1 kg/m2 preoperatively to 31.7±5.6 kg/m2 at 6 months (17.4% excess weight loss) and 30.5±6.9 kg/m2 at 1 year (25.7% excess weight loss). The average length of latest follow-up was 20.7 months. CONCLUSION: "Candy cane" syndrome is a real phenomenon that can be managed safely with excellent outcomes with resection of the blind afferent limb. A thorough diagnostic workup is paramount to proper identification of this syndrome. Surgeons should minimize the size of the blind afferent loop left at the time of initial RYGB.


Subject(s)
Abdominal Pain/etiology , Gastric Bypass/adverse effects , Laparoscopy/adverse effects , Nausea/etiology , Abdominal Pain/surgery , Female , Humans , Male , Middle Aged , Nausea/surgery , Obesity, Morbid/surgery , Pain, Postoperative/etiology , Pain, Postoperative/surgery , Postoperative Complications/etiology , Postoperative Complications/surgery , Prospective Studies , Reoperation/statistics & numerical data , Retrospective Studies , Syndrome , Treatment Outcome
12.
Obes Surg ; 27(8): 1929-1937, 2017 08.
Article in English | MEDLINE | ID: mdl-28213666

ABSTRACT

BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) is increasingly being applied to treat obesity. LSG includes excision of the normal gastric pacemaker, which could induce electrical dysrhythmias impacting on post-operative symptoms and recovery, but these implications have not been adequately investigated. This study aimed to define the effects of LSG on gastric slow-wave pacemaking using laparoscopic high-resolution (HR) electrical mapping. METHODS: Laparoscopic HR mapping was performed before and after LSG using flexible printed circuit arrays (64-96 electrodes; 8-12 cm2; n = 8 patients) deployed through a 12 mm trocar and positioned on the gastric serosa. An additional patient with chronic reflux, nausea, and dysmotility 6 months after LSG also underwent gastric mapping while undergoing conversion to gastric bypass. Slow-wave activity was quantified by propagation pattern, frequency, velocity, and amplitude. RESULTS: Baseline activity showed exclusively normal propagation. Acutely after LSG, all patients developed either a distal unifocal ectopic pacemaker with retrograde propagation (50%) or bioelectrical quiescence (50%). Propagation velocity was abnormally rapid after LSG (12.5 ± 0.8 vs baseline 3.8 ± 0.8 mm s-1; p = 0.01), whereas frequency and amplitude were unchanged (2.7 ± 0.3 vs 2.8 ± 0.3 cpm, p = 0.7; 1.7 ± 0.2 vs 1.6 ± 0.6 mV, p = 0.7). In the patient with chronic dysmotility after LSG, mapping also revealed a stable antral ectopic pacemaker with retrograde rapid propagation (12.6 ± 4.8 mm s-1). CONCLUSION: Resection of the gastric pacemaker during LSG acutely resulted in aberrant distal ectopic pacemaking or bioelectrical quiescence. Ectopic pacemaking can persist long after LSG, inducing chronic dysmotility. The clinical and therapeutic significance of these findings now require further investigation.


Subject(s)
Electrophysiological Phenomena/physiology , Gastrectomy/adverse effects , Gastrointestinal Diseases/diagnosis , Gastrointestinal Motility/physiology , Laparoscopy/methods , Postoperative Complications/diagnosis , Adult , Biological Clocks/physiology , Electric Stimulation , Female , Gastrectomy/methods , Gastric Bypass/adverse effects , Gastric Bypass/methods , Gastroesophageal Reflux/diagnosis , Gastroesophageal Reflux/etiology , Gastroesophageal Reflux/physiopathology , Gastrointestinal Diseases/etiology , Gastrointestinal Diseases/physiopathology , Humans , Male , Middle Aged , Nausea/etiology , Nausea/physiopathology , Nausea/surgery , Obesity, Morbid/surgery , Postoperative Complications/etiology , Postoperative Complications/physiopathology , Stomach/physiopathology , Stomach/surgery
13.
J Neurol Surg A Cent Eur Neurosurg ; 77(5): 395-9, 2016 Sep.
Article in English | MEDLINE | ID: mdl-27168319

ABSTRACT

Background A considerable number of patients with cervical spondylosis complain about one or multiple atypical symptoms such as vertigo, palpitations, headache, blurred vision, hypomnesia, and/or nausea. It remains unclear whether surgical intervention for cervical spondylosis can also effectively alleviate those symptoms. The current study was performed to see if anterior cervical diskectomy and fusion (ACDF) offers such an extra benefit for patients with cervical spondylosis. Objective To investigate if patients who received ACDF for the treatment of cervical spondylotic myelopathy and/or radiculopathy can also achieve alleviation of certain atypical symptoms associated with cervical spondylosis after the surgery in the long run. Methods Sixty-seven patients who underwent ACDF for the treatment of cervical spondylotic myelopathy and/or radiculopathy were involved in this study. All these patients also complained about various associated atypical symptoms. They were followed up for 26 to 145 months after the surgery. Severity and frequency scores of the atypical symptoms before the surgery and at last follow-up were compared by paired t tests. Results Most patients reported significantly alleviated symptoms at the last follow-up compared with before the surgery. The severity of vertigo, headache, nausea, and palpitations were significantly alleviated at the last follow-up (with p values of p < 0.001, p = 0.001, p = 0.022, p = 0.004, respectively). There were no significant changes in the severity of tinnitus (p = 0.182), blurred vision (p = 0.260), and hypomnesia (p = 0.821). Conclusion ACDF can significantly alleviate vertigo, headache, nausea, and palpitations in most patients with cervical spondylotic myelopathy and/or radiculopathy, but it is not effective in alleviating symptoms such as tinnitus, blurred vision, and hypomnesia. It can be considered for alleviating atypical symptoms when other treatment options prove ineffective.


Subject(s)
Cervical Vertebrae/surgery , Diskectomy/methods , Spinal Fusion/methods , Spondylosis/surgery , Adult , Aged , Female , Headache/etiology , Headache/surgery , Humans , Male , Middle Aged , Nausea/etiology , Nausea/surgery , Retrospective Studies , Spondylosis/complications , Tinnitus/etiology , Tinnitus/surgery , Treatment Outcome , Vertigo/etiology , Vertigo/surgery , Vision Disorders/etiology , Vision Disorders/surgery
14.
J Gastrointest Surg ; 19(3): 411-7, 2015 Mar.
Article in English | MEDLINE | ID: mdl-25575765

ABSTRACT

INTRODUCTION: Gastroparesis is a functional disorder resulting in debilitating nausea, esophageal reflux, and abdominal pain and is frequently refractory to medical treatment. Therapies such as pyloroplasty and neurostimulators can improve symptoms. When medical and surgical treatments fail, palliative gastrectomy is an option. We examined outcomes after gastrectomy for postoperative, diabetic, and idiopathic gastroparesis. METHODS: A prospective database was queried for gastrectomies performed for gastroparesis from 1999 to 2013. Primary outcomes were improvements in pre- versus postoperative symptoms at last follow-up, measured on a five-point scale. Secondary outcome was operative morbidity. RESULTS: Thirty-five patients underwent laparoscopic total or near-total gastrectomies for postoperative (43 %), diabetic (34 %), or idiopathic (23 %) gastroparesis. Antiemetics and prokinetics afforded minimal relief for one third of patients. There were no mortalities. Six patients suffered a leak, all treated with surgical reintervention. With a median follow-up of 6 months, nausea improved or resolved in 69 %. Chronic abdominal pain improved or resolved in 70 %. Belching and bloating resolved for 79 and 89 %, respectively (p < 0.01). CONCLUSIONS: Regardless of etiology, medically refractory gastroparesis can be a devastating disease. Near-total gastrectomy can ameliorate or relieve nausea, belching, and bloating. Chronic abdominal pain commonly resolved or improved with resection. Despite attendant morbidity, gastrectomy can effectively palliate symptoms of gastroparesis.


Subject(s)
Diabetes Complications/surgery , Gastrectomy/methods , Gastroparesis/surgery , Postoperative Complications/surgery , Abdominal Pain/surgery , Diabetes Complications/complications , Eructation/surgery , Female , Gastroesophageal Reflux/surgery , Gastroparesis/drug therapy , Gastroparesis/etiology , Humans , Laparoscopy , Male , Middle Aged , Nausea/surgery , Retreatment , Severity of Illness Index , Treatment Outcome
16.
J Gastrointest Surg ; 18(3): 491-6, 2014 Mar.
Article in English | MEDLINE | ID: mdl-24234246

ABSTRACT

BACKGROUND: The role of gastrectomy in the face of incurable gastric cancer is evolving. We sought to evaluate our experience with incomplete (i.e., R2) gastrectomy in advanced gastric cancer. METHODS: We reviewed 210 locally advanced or metastatic gastric cancers (1992-2008). Patient characteristics and outcomes were compared between three groups: gastrectomy (N = 99), exploration without resection (N = 66), and no surgery (N = 45). RESULTS: Clinicopathologic characteristics were similar between groups. Symptoms successfully resolved after gastrectomy in 48 % with a complication rate of 32 % and mortality of 6 %. Overall median survival for all patients was 6.2 months: 10.0 months after gastrectomy, 4.1 months after exploration without resection, and 5.3 months for no surgery (p < 0.001). Perioperative complications were the only predictor of symptom resolution following resection (OR = 0.175). Resolution of symptoms (p < 0.001, Hazards Ratio (HR) = 0.09) and preoperative nausea/vomiting (p = 0.017, HR = 0.55) improved survival, while linitis plastica (p = 0.035, HR = 4.05) and spindle cell morphology (p = 0.011, HR = 1.98) were predictors of poor survival in patients undergoing resection. CONCLUSIONS: Gastrectomy in the setting of advanced gastric cancer may be useful in up to half of patients with an acceptable perioperative mortality rate. Symptom resolution offers a potential survival advantage but is dependent upon a complication-free course, so should only be considered selectively.


Subject(s)
Gastrectomy , Palliative Care , Stomach Neoplasms , Abdominal Pain/etiology , Abdominal Pain/surgery , Anastomotic Leak/etiology , Female , Gastrectomy/adverse effects , Gastrectomy/mortality , Gastric Outlet Obstruction/etiology , Gastric Outlet Obstruction/surgery , Humans , Male , Nausea/etiology , Nausea/surgery , Neoplasm Metastasis , Neoplasm Staging , Stomach Neoplasms/complications , Stomach Neoplasms/mortality , Stomach Neoplasms/pathology , Stomach Neoplasms/surgery , Survival Rate , Vomiting/etiology , Vomiting/surgery , Weight Loss
18.
Obes Surg ; 23(4): 480-5, 2013 Apr.
Article in English | MEDLINE | ID: mdl-23239032

ABSTRACT

BACKGROUND: Laparoscopic Roux-en-Y gastric bypass (RYGB) is an effective treatment for morbid obesity. Failure of weight loss has been reported in 10 to 30% of RYGB patients. Silastic ring RYGB was introduced to minimize failure rate, however, with higher complication rate. The aim of our study is to evaluate the safety of utilizing pericardial patch as a ring on RYGB patients. METHODS: Between March 2010 and June 2011, a total of 189 patients underwent pericardial patch ring RYGB at the Bariatric and Laparoscopy Center. A retrospective review of a prospectively collected database was performed for all pericardial patch ring RYGB patients, noting the outcomes and complications of the procedure. RESULTS: Pericardial patch ring RYGB patients demonstrated a mean percentage of excess weight loss of 57.4% at a mean follow-up of 11 months. Out of 164 patients with follow-up, five (3.0%) patients required endoscopic balloon dilation due to dysphagia, abdominal pain, and/or gastric outlet obstruction. All patients did well after the procedure. Three (1.8%) patients underwent diagnostic laparoscopy for abdominal pain. Of these patients, one (0.6%) had dilated and enlarged blind limb, and two (1.2%) patients had partial small bowel obstruction. No patient was readmitted or reoperated due to pericardial patch ring. CONCLUSIONS: Longer follow-up is needed to prove the true efficacy of this procedure in reducing weight gain. Pericardial patch ring RYGB seems to be a safe alternative for banded RYGB of other materials.


Subject(s)
Abdominal Pain/surgery , Gastric Bypass/adverse effects , Gastric Bypass/methods , Nausea/surgery , Obesity, Morbid/surgery , Pericardium/transplantation , Abdominal Pain/etiology , Adolescent , Adult , Body Mass Index , Female , Humans , Length of Stay/statistics & numerical data , Male , Middle Aged , Nausea/etiology , Obesity, Morbid/complications , Reoperation/statistics & numerical data , Retrospective Studies , Treatment Outcome , Weight Gain , Weight Loss
19.
Auton Neurosci ; 133(2): 175-7, 2007 May 30.
Article in English | MEDLINE | ID: mdl-17291834

ABSTRACT

The carotid sinus syndrome (CSS) is characterized by repetitive syncope due to prolonged heart rate slowing or a profound drop in systolic blood pressure. CSS is due to an inappropriate response of a hypersensitive carotid sinus following pressure on or stretching of the neck. We report on a patient with excessive gagging and vomiting elicited by pressure on the right side of the neck as an aberrant presentation of the carotid sinus syndrome. Her incapacitating symptoms were abolished by a surgical carotid denervation.


Subject(s)
Baroreflex/physiology , Carotid Sinus/surgery , Reflex, Abnormal/physiology , Syncope/complications , Syncope/physiopathology , Vomiting/surgery , Bradycardia/etiology , Bradycardia/physiopathology , Carotid Sinus/innervation , Carotid Sinus/physiopathology , Denervation/methods , Female , Glossopharyngeal Nerve/physiopathology , Glossopharyngeal Nerve/surgery , Humans , Middle Aged , Nausea/etiology , Nausea/physiopathology , Nausea/surgery , Neurosurgical Procedures/methods , Treatment Outcome , Vagus Nerve/physiopathology , Vagus Nerve/surgery , Visceral Afferents/physiopathology , Visceral Afferents/surgery , Vomiting/etiology , Vomiting/physiopathology
20.
Acta méd. (Porto Alegre) ; 27: 138-148, 2006.
Article in Portuguese | LILACS | ID: lil-441013

ABSTRACT

As náuseas e os vômitos em pós-operatório das mais variadas cirurgias são complicações extremamente freqüentes e desconfortáveis para o paciente. Porém muitas vezes, não é considerada uma alteração importante por, na maior parte das vezes, não ter repercussões maiores e por ser vista como uma complicação prevista tanto na cirurgia quanto da anestesia.Em contrapartida, sabe-se que em pacientes selecionados a ocorrência desses sintomas pode ter conseqüências importantes, aumentando a morbidade e a mortalidade pós-operatórias. Desse modo, nessa revisão, os autores visam auxiliar os profissionais da área médica a identificar fatores de risco que possam propiciar náuseas e vômitos no pós-operatório de pacientes que serão submetidos à anestesia e procedimento cirúrgico. A partir disso, pretende-se, de modo sistemático, orientar o manejo profilático e terapêutico para esses sintomas de acordo com o perfil de cada paciente, além de evitar, quando possível, fatores que possam contribuir para o desencadeamento destes.


Subject(s)
Humans , Nausea/surgery , Vomiting/surgery
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