ABSTRACT
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Subject(s)
Humans , Female , Middle Aged , Fluorodeoxyglucose F18 , Brain Neoplasms , Breast Neoplasms/complications , Breast Neoplasms , Neoplasm Metastasis/pathology , Neoplasm Metastasis , Neoplasms, Ductal, Lobular, and Medullary/complications , Neoplasms, Ductal, Lobular, and Medullary/pathology , Neoplasms, Ductal, Lobular, and MedullaryABSTRACT
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Subject(s)
Female , Humans , Middle Aged , Adenocarcinoma/complications , Adenocarcinoma/surgery , Adenocarcinoma , Neoplasms, Ductal, Lobular, and Medullary/complications , Carcinoma, Pancreatic Ductal/complications , Carcinoma, Pancreatic Ductal/surgery , Carcinoma, Pancreatic Ductal , Gastrectomy/methods , Gastrectomy/trends , Carcinoma, Pancreatic Ductal/physiopathology , Surgical Wound Dehiscence/complications , Surgical Wound Dehiscence/surgery , Diagnosis, Differential , Quality of LifeABSTRACT
Aim. Our study has aimed to establish the prevalence and pathological nature of fluorine-18-fluorodeoxyglucose (18F-FDG) breast incidental uptake (BIU) in patients studied for non-malignant breast tumours and then to compare our data obtained in three Italian nuclear medicine centres with those available in literature. Material and methods. We retrospectively evaluated 42,927 18F-FDG-PET/CT scans performed on patients studied in three Italian Nuclear Medicine Centres. All patients underwent 18F-FDG-PET/CT for oncologic purposes not related to breast disease. Results. Among 42,927 scans, a BIU was identified in 79 (0.18%) patients, 75 (95%) female and 4 (5%) male with an average age of 62 ± 17 years. Twenty-five out of 35 (71.5%) BIUs were malignant and 10/35 (28.5%) benign. Among the 25/35 incidentalomas that were malignant, 12/25 (48%) were infiltrating ductal carcinoma, 5/25 (20%) ductal carcinoma (infiltrating and in situ), 4/25 (16%) lobular carcinoma, 2/25 (8%) ductal carcinoma in situ and 2/25 (8%) were metastases from the primary tumour under investigation. Of the 10 BIUs that were benign in the histological examination, after further investigations it was found that 9/10 (90%) were fibroadenomas and 1/10 (10%) was a benign lesion not better specified. The lesion to liver or to blood-pool SUVmax ratio in malignant lesions is significantly higher than in benign ones. Conclusions. Our multicenter study demonstrates that, although they are uncommon, BIUs show a high percentage of malignancy and therefore requires further research (AU)
Objetivo. Objetivo de nuestro estudio fue establecer la prevalencia y el carácter patológico de la captación incidental en la mama (CIM) de 18F-FDG en pacientes evaluados para tumores malignos de origen no-mamario y luego comparar nuestros datos obtenido en tres centros Italianos de Medicina Nuclear con los que están disponibles en literatura. Material y métodos. Hemos evaluado retrospectivamente 42.927 estudios 18F-FDG-PET/TAC de pacientes en tres centros Italianos de Medicina Nuclear; todos los pacientes se han sometidos a una exploración 18F-FDG-PET/TAC por fines oncológicos no relacionados con la patología mamaria. Resultados. Entre 42.927 exploraciones, una CIM fue identificada en 79 (0.18%) pacientes, 75 (95%) mujeres y 4 (5%) hombres, con una edad media de 62 ± 17 años. Veinticinco de 35 (71.5%) CIM fueron malignas y 10/35 (28.5%) benignas. Entre los incidentalomas malignos, 12/25 (48%) eran carcinomas ductales infiltrantes, 5/25 (20%) carcinomas ductales (infiltrantes e in situ), 4/25 (16%) carcinomas lobulares, 2/25 (8%) carcinomas ductales in situ y 2/25 (8%) eran metástasis de tumour primario objeto de investigación. Entre 10 CIM que fueron identificados como benignos en el examen histológico después de investigación adicional, 9/10 (90%) fueron fibroadenomas y 1/10 (10%) fue una lesión benigna no mejor especificada. El ratio del SUVmáx de la lesión en comparación con el hígado o con el pool vascular es significativamente mayor en las lesiones malignas que en las benignas. Conclusiones. Nuestro estudio multicéntrico demuestra que, aunque son poco frecuentes, las CIM muestran un alto porcentaje de malignidad, por lo tanto las CIM necesitan investigación adicional (AU)
Subject(s)
Humans , Female , Adult , Middle Aged , Aged , Aged, 80 and over , Breast Neoplasms , Fluorodeoxyglucose F18 , Nuclear Medicine/methods , Nuclear Medicine/standards , Incidental Findings , Retrospective Studies , Neoplasms, Ductal, Lobular, and Medullary/complications , Neoplasms, Ductal, Lobular, and Medullary/diagnosis , Neoplasms, Ductal, Lobular, and Medullary , Fibroadenoma/complications , FibroadenomaABSTRACT
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Subject(s)
Male , Middle Aged , Humans , Aneurysm, False/complications , Aneurysm, False/surgery , Aneurysm, False , Internal Mammary-Coronary Artery Anastomosis/methods , Internal Mammary-Coronary Artery Anastomosis/trends , Internal Mammary-Coronary Artery Anastomosis , Mammary Arteries/pathology , Mammary Arteries , Sentinel Lymph Node Biopsy/methods , Sentinel Lymph Node Biopsy , Aneurysm, False/physiopathology , Axillary Artery/pathology , Axillary Artery , Anticoagulants/therapeutic use , Neoplasms, Ductal, Lobular, and Medullary/complications , Neoplasms, Ductal, Lobular, and Medullary/surgery , Neoplasms, Ductal, Lobular, and Medullary , Carcinoma, Ductal, Breast/complicationsABSTRACT
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Subject(s)
Humans , Male , Adult , Hamartoma/complications , Hamartoma/diagnosis , Breast Neoplasms, Male/complications , Breast Neoplasms, Male/diagnosis , Breast/anatomy & histology , Breast/pathology , Breast Neoplasms, Male/physiopathology , Breast Neoplasms, Male , Neoplasms, Ductal, Lobular, and Medullary/complications , Carcinoma, Lobular/complications , Carcinoma, Lobular/diagnosisSubject(s)
Humans , Male , Adult , Breast Neoplasms, Male/complications , Breast Neoplasms, Male/diagnosis , Breast Neoplasms, Male/drug therapy , Biomarkers, Tumor/isolation & purification , Breast Neoplasms, Male/physiopathology , Breast Neoplasms, Male , Neoplasms, Ductal, Lobular, and Medullary/complications , Carcinoma, Ductal, Breast/complications , Carcinoma, Ductal, Breast/drug therapy , Carcinoma, Ductal, Breast , Cyclophosphamide/therapeutic useABSTRACT
Differential diagnosis of solid pancreatic lesions remains as an important clinical challenge, mainly for the differentiation between mass forming chronic pancreatitis, autoimmune pancreatitis and pancreatic adenocarcinoma. Endoscopic ultrasound (EUS), computed tomography (CT) and magnetic resonance imaging (MRI) can all provide valuable and complementary information in this setting. Among them, EUS has the unique ability to obtain specimens for histopathological diagnosis and can therefore play a crucial role in the evaluation patients with inconclusive findings on initial examinations. Nowadays, new developed techniques associated to EUS, like elastography and contrast enhancement, have shown promising results for the differential diagnosis of these pancreatic lesions(AU)
Subject(s)
Humans , Male , Female , Diagnosis, Differential , Endoscopy/methods , Endoscopy , Pancreatitis/complications , Pancreatitis/diagnosis , Neoplasms, Ductal, Lobular, and Medullary/complications , Neoplasms, Ductal, Lobular, and Medullary/diagnosis , Carcinoma, Pancreatic Ductal/complications , Carcinoma, Pancreatic Ductal/diagnosis , Pancreatitis , Carcinoma, Pancreatic Ductal , Magnetic Resonance Imaging/methods , Magnetic Resonance ImagingSubject(s)
Humans , Female , Breast Neoplasms/complications , Breast Neoplasms/surgery , Neoplasms, Ductal, Lobular, and Medullary/complications , Neoplasms, Ductal, Lobular, and Medullary/surgery , Carcinoma, Ductal, Breast/complications , Brachial Plexus/pathology , /methods , Biopsy, Needle/methodsABSTRACT
La incidencia de metástasis endobronquiales secundarias a tumores sólidos es baja. Los tumores primarios que con más frecuencia producen metástasis endobronquiales son la mama, el colon y los tumores renales. Normalmente se presentan como una manifestación tardía de la enfermedad con un pronóstico malo y por su forma inespecífica de presentación precisan diagnóstico diferencial con los tumores pulmonares primarios (AU)
Endobronchial metastases secondary to extrapulmonary solid malignant tumours are rare. The most frequent primary tumours associated with endobronchial involvement are breast, colon and renal cell carcinoma. Endobronchial metastases usually appear later with a poorer prognosis and require differential diagnosis from a primary lung cancer (AU)
Subject(s)
Humans , Female , Adult , Dyspnea/complications , Dyspnea/diagnosis , Dyspnea/drug therapy , Breast Neoplasms/complications , Breast Neoplasms/diagnosis , Neoplasm Metastasis/diagnosis , Neoplasm Metastasis/physiopathology , Spirometry/methods , Radiography, Thoracic/methods , Bronchoscopy/methods , Neoplasms, Multiple Primary/complications , Diagnosis, Differential , Neoplasms, Ductal, Lobular, and Medullary/complications , Neoplasms, Ductal, Lobular, and Medullary/diagnosis , Breast Neoplasms/drug therapy , Breast Neoplasms/radiotherapySubject(s)
Humans , Female , Middle Aged , Neoplasm Metastasis/diagnosis , Rectal Neoplasms/complications , Rectal Neoplasms , Rectum/pathology , Rectum , Signal Processing, Computer-Assisted/instrumentation , Neoplasms, Ductal, Lobular, and Medullary/complications , Neoplasms, Ductal, Lobular, and Medullary/diagnosis , Carcinoma, Lobular/complications , Carcinoma, Lobular/diagnosis , Rectum/cytology , /instrumentationABSTRACT
El porcentaje de mujeres menores de 35 años afectas decáncer de mama es pequeño en comparación con otros subgruposde edad. Constituye, sin embargo, un conjunto de pacientescon unas particularidades especiales.Se presentan los datos de una encuesta multicéntrica, decarácter retrospectivo, sobre 225 mujeres con cáncer demama tratadas entre los años 1984 y 2007. Destaca la presentaciónclínica como nódulo palpable y la elevada proporciónde mastectomía como técnica quirúrgica como resultadosmás significativos. El carcinoma ductal infiltrante (73%) fue eltipo histológico más frecuente, siendo la mayoría de los tumoresde grado intermedio o alto, con una elevada proporción decomponente intraductal extenso (34,6%) e invasión linfovascular(42,4%). En el momento de la recogida de datos, el 77%de las mismas estaban en seguimiento clínico, libres de enfermedad.Los resultados de este estudio inicial invitan a considerar diferenciadamenteeste subgrupo de la enfermedad, que debeser tratado dentro de un grupo multidisciplinar (Unidad deMama)(AU)
The subgroup of breast cancer patients younger than 35years comprises a small percentage of all the women affectedby this neoplasm, although, it offers some particular aspects.We present the results of a multicentric query on 225 youngpatients treated of breast cancer. We underline the presenceof a palpable mass as the most frequent clinical presentationand the high percentage of mastectomy as the most highlightedresults. Ductal infiltrating carcinoma was the most frequenthistologic type (73%). The majority of tumors exhibited intermediateo high grade features. There was a high percentageof extensive intraductal component (34,6%) and lymphovascularinvasion (42,4%). At the moment, 77% of patients werealive and disease free.These preliminary results should consider a differentiatedapproach to this subgroup of young women, who should betreated multidisciplinary in a breast unit(AU)
Subject(s)
Humans , Female , Adult , Breast Neoplasms/epidemiology , Neoplasms, Ductal, Lobular, and Medullary/complications , Carcinoma, Ductal, Breast/complications , Carcinoma, Ductal, Breast/diagnosis , Carcinoma, Ductal, Breast/epidemiology , Prognosis , Follow-Up Studies , Socioeconomic Survey , Data Collection , Retrospective Studies , Breast Neoplasms/drug therapy , Breast Neoplasms/radiotherapy , Anthracyclines/therapeutic use , BiomarkersABSTRACT
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Subject(s)
Humans , Male , Middle Aged , Hemangioma/diagnosis , Hemangioma/pathology , Arteriovenous Malformations/diagnosis , Hemangioma, Capillary/surgery , Hemangioma, Capillary/therapy , Neoplasms, Ductal, Lobular, and Medullary/complications , Neoplasms, Ductal, Lobular, and Medullary/diagnosis , Methotrexate/adverse effects , Cryotherapy/methods , Electrocoagulation/methods , Hemangioma, Capillary/pathology , Neoplasms, Ductal, Lobular, and Medullary/pathology , Stromal Cells/cytology , Stromal Cells/pathology , Endometrial Stromal Tumors/epidemiology , Tomography, Emission-Computed/methodsABSTRACT
Objetivo: Se presenta un caso de adenocarcinoma ductal prostático, anteriormente conocido como carcinoma endometrioide y se revisa la literatura. Métodos: Paciente de 75 años que acude a la consulta por sintomatología de obstrucción urinaria, PSA de 8,1 ng/ml., sin otra clínica acompañante. El tacto rectal y la ecografía abdominopélvica evidencian una próstata pequeña y pétrea. Se realiza resección transuretral desobstructiva y la anatomía patológica revela carcinoma ductal del utrículo prostático. Resultados: A los 9 años del diagnóstico no presenta signos de diseminación. Conclusiones: De hallazgo casual en el estudio anatomo-patológico, el adenocarcinoma ductal del utrículo prostático es una rara neoformación, cuya incidencia entre todos los carcinomas prostáticos ha sido citada entre 0,2-0,8%, si bien resulta interesante hacer una revisión sobre el tema para fomentar su estudio. Se revisan la clínica, diagnóstico y tratamiento de dicho carcinoma (AU)
Objective: A case of ductal carcinoma of the prostatic utricle is described, previously known as endometrial carcinoma, and literature is reviewed. Methods: 75 years old patient who consults for lower urinary tract obstructive symptoms, with a PSA of 8.1 ng/ml., without more symptoms. Digital rectal examination and ultrasound showed a small and stony prostate. Deobstructive transurethral resection of the prostate was performed and the biopsy revealed ductal carcinoma of the utricle. Results: Nine years after diagnosis signs of dissemination are not present. Conclusions: As incidental finding in the biopsy, ductal carcinoma of the utricle is a rare tumor, the incidence of which among all prostatic carcinomas has been cited as 0.2-0.8%. We report a review about this topic for improving its knowledge. Symptoms, pathological findings and treatment of this carcinoma have been reviewed (AU)
Subject(s)
Humans , Male , Middle Aged , Carcinoma/complications , Carcinoma/diagnosis , Carcinoma/surgery , Neoplasms, Ductal, Lobular, and Medullary/complications , Neoplasms, Ductal, Lobular, and Medullary/diagnosis , Carcinoma, Ductal/complications , Carcinoma, Ductal/diagnosis , Saccule and Utricle/pathology , Saccule and Utricle , Prostate/pathology , Prostate , Prostatic Neoplasms/diagnosis , Prostatic Neoplasms/pathologyABSTRACT
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Subject(s)
Female , Middle Aged , Humans , Mammography/methods , Carcinoma, Ductal, Breast/complications , Carcinoma, Ductal, Breast/diagnosis , Breast Neoplasms/complications , Breast Neoplasms/diagnosis , Neoplasm Metastasis/diagnosis , Neoplasm Metastasis/physiopathology , Neoplasms, Ductal, Lobular, and Medullary/complications , Neoplasms, Ductal, Lobular, and Medullary/diagnosis , Carcinoma, Ductal, Breast , Neoplasms, Ductal, Lobular, and MedullaryABSTRACT
El tejido mamario ectópico está sujeto a las mismas influencias hormonales y riesgos de patología, incluyendo carcinomas, que las mamas. La incidencia de carcinoma en tejido ectópico es aproximadamente un 0,3% de todos los cánceres de mama y la localización más frecuente es en axila. El tratamiento debe seguir las mismas recomendaciones que en el cáncer de mama con igual estadio TNM (AU)
Ectopic breast tissue is subject to the same hormonal influences and risk of disease, including carcinoma, as the breast. The incidence of carcinoma in ectopic tissue is approximately 0.3% of all breast cancer and the most frequent localization is the axilla. Treatment should follow the recommendations for breast cancer with the same tumor-node-metastases (TNM) stage (AU)
Subject(s)
Female , Humans , Mammography/methods , Ultrasonography, Mammary/methods , Mastectomy/methods , Carcinoma, Ductal, Breast/complications , Carcinoma, Ductal, Breast/diagnosis , Carcinoma, Ductal, Breast/surgery , Breast Neoplasms/complications , Breast Neoplasms/diagnosis , Breast Neoplasms/surgery , Neoplasms, Ductal, Lobular, and Medullary/complications , Biopsy, Fine-Needle , Lymphatic Metastasis/pathology , Lymphatic Metastasis/physiopathology , Diagnosis, Differential , Breast Neoplasms/drug therapy , Breast Neoplasms/radiotherapyABSTRACT
Presentamos el caso de una mujer de 32 años que acudió a nuestra consulta con múltiples nódulos en el brazo izquierdo y mama homolateral de 15 años de evolución. Estas lesiones tenían una coloración azulada y eran dolorosas. Pocos años atrás le habían extirpado en el brazo izquierdo otras tres lesiones similares con el diagnóstico histopatológico de espiradenoma. Todos los nódulos estaban dispuestos siguiendo un trayecto lineal y bajo una lesión maculopapulosa eritematosa que clínicamente parecía corresponder a un nevo epidérmico. Los casos de espiradenomas múltiples son muy raros y más aún los espiradenomas múltiples que adoptan una disposición lineal
We report the case of a 32-year old woman who presented with multiple nodules in the left arm and breast that had been present for 15 years. These nodules had a bluish colour and were occasionally painful. She had gone under excision of three other nodules on the left arm with the histopathological diagnosis of spiradenoma. All of the nodules were disposed in a linear arrangement and underneath a maculo-papular erythematous lesion which clinically seemed to be an epidermal nevus. The case described in the literature of multiple spiradenomas are vey rare and multiple linear spiradenomas are even rarer
Subject(s)
Female , Adult , Humans , Adenoma, Sweat Gland/diagnosis , Hyperpigmentation/diagnosis , Sweat Glands/pathology , Skin Neoplasms/diagnosis , Skin Neoplasms/surgery , Sweat Gland Neoplasms/diagnosis , Sweat Glands/surgery , Adenoma, Sweat Gland/complications , Sweat Glands , Nevus/complications , Nevus/diagnosis , Hyperpigmentation/complications , Hyperpigmentation/physiopathology , Sweat Gland Neoplasms/complications , Neoplasms, Ductal, Lobular, and Medullary/complications , Neoplasms, Ductal, Lobular, and Medullary/diagnosisABSTRACT
Primary non-Hodgkin lymphoma of the breast is a rare disease. Primary mucosa-associated lymphoid tissue lymphoma is even rarer, and bilateral involvement is exceptional. We describe a case of primary bilateral breast mucosa-associated lymphoid tissue lymphoma with bilateral atypical ductal hyperplasia and bilateral localized amyloidosis in a 64-year-old woman with a history of arthritis and systemic lupus erythematosus and its clinical, histologic, and immunohistochemical features. Microscopic examination of the breast lesion showed dense periductal and perilobular small and plasmacytoid lymphocytes with eosinophilic amyloid in the vessels and the stroma. Bilateral single foci of atypical ductal hyperplasia were also noted. Fine needle aspiration showed small and large lymphocytes and plasma cells. Molecular analysis demonstrated a heavy chain immunoglobulin H gene rearrangement. Flow cytometry studies showed an abnormal B-cell population. The combined histologic, paraffin immunohistochemistry, flow cytometry, and molecular results were considered diagnostic for low-grade mucosa-associated lymphoid tissue lymphoma. The patient underwent bilateral local breast radiation without other organ or site involvement.
