ABSTRACT
Mixed epithelial and stromal tumor of the kidney is a newly categorized lesion, with few reported cases. We report a rare case of a 45-year-old woman with a palpable abdominal mass and elevated serum level of serum cancer antigen 125, who was not receiving hormones or contraceptive agents. Abdominal magnetic resonance imaging revealed a large multilocular cystic tumor that arose in the left central kidney. Nephrectomy was performed under the initial impression of cystic renal cell carcinoma; however, a diagnosis of mixed epithelial and stromal tumor was confirmed according to pathological and immunohistochemical findings. Serum level of cancer antigen 125 returned to normal after 1 month postoperatively and no recurrence was found in the following 18 months.
Subject(s)
Carcinoma, Renal Cell/pathology , Kidney Neoplasms/pathology , Mixed Tumor, Malignant/pathology , Nephroma, Mesoblastic/pathology , CA-125 Antigen/blood , Carcinoma, Renal Cell/blood , Carcinoma, Renal Cell/surgery , Diagnosis, Differential , Epithelial Cells/metabolism , Epithelial Cells/pathology , Female , Humans , Immunohistochemistry , Kidney Neoplasms/blood , Kidney Neoplasms/surgery , Magnetic Resonance Imaging , Middle Aged , Mixed Tumor, Malignant/blood , Mixed Tumor, Malignant/surgery , Nephrectomy , Nephroma, Mesoblastic/blood , Nephroma, Mesoblastic/surgery , Polycystic Kidney Diseases/pathology , Stromal Cells/metabolism , Stromal Cells/pathology , Treatment OutcomeABSTRACT
Urine and serum samples of rats bearing three different experimental tumours (hepatocellular carcinoma, myelomonocytic leukemia and mesoblastic nephroma) were investigated for mutagenicity with the Ames Salmonella test. Enhancement of mutagenic activity in TA98 and TA100 was observed only in the case of urine samples obtained from animals bearing nephromas. Mutagenicity increased with increasing time after implantation of tumours. There was no coincidence between urinary and serum mutagenicity under the experimental conditions employed. Further studies are needed to determine the origins, and chemical and genotoxic characteristics of urinary mutagens. In addition, the question as to whether any mutagenic substances can be detected in fractions of plasma/serum should also be experimentally addressed.
