Comparison of clinical outcomes following early rehabilitation in 3 cases of nephrotic syndrome with different treatment courses.

There have been few published reports regarding rehabilitation for nephrotic syndrome. We compared the clinical outcomes of three cases of nephrotic syndrome with different treatment courses during 5 weeks of early rehabilitation.We report on three cases of nephrotic syndrome. Case 1 was a 67-year-old male who showed good progress after steroid treatment. Quadriceps torque and exercise capacity were increased after intervention. Case 2, a 78-year-old male, demonstrated resistance to steroid treatment. Quadriceps torque was decreased and exercise capacity was increased after intervention. Case 3 was an 83-year-old male who received nutrition therapy and diuretics without steroid treatment. Quadriceps torque and exercise capacity were decreased post-intervention.Early rehabilitation should be considered even if the steroid treatment course is different; furthermore, it is necessary to carefully consider the optimal exercise load in patients with nephrotic syndrome for whom regardless of whether or not steroid treatment is used.

Evaluation of the safety, effectiveness, and health-related QOL impact of early rehabilitation in patients with nephrotic syndrome.

BACKGROUND: The aim of this study was to evaluate the safety, effectiveness, and health-related QOL impact of early rehabilitation in patients with nephrotic syndrome. METHODS: Subjects consisted of 23 patients with nephrotic syndrome who had previously received steroid treatment. Patients worked performed quadriceps resistance training and aerobic training 5 days per week for 5 weeks. Urinary protein, albumin (Alb), creatinine (Cre), and blood urea nitrogen (BUN) were monitored once every week over a 5-week period based on medical records. The 36-item short form health survey (SF-36) score was used to evaluate health-related QOL. RESULTS: There was no significant difference in quadriceps force and no significant effect of age as shown by ANCOVA. Anaerobic threshold (AT) and peak oxygen consumption (peak VO2) both increased significantly. AT was affected by the degree of change in body weight according to ANCOVA. Cre and BUN were not significantly altered. Urinary protein showed a significant decrease and Alb was significantly increased. Only physical function (PF) in the SF-36 showed a significant improvement following the intervention. CONCLUSION: Our data indicate that early rehabilitation involving quadriceps resistance training and aerobic training for nephrotic syndrome is safe and effective.

[The restoration of cardiovascular system function in patients with chronic glomerulonephritis after the use in staged medical rehabilitation of measured therapeutic physical exercise]. / Vidnovlennia funktsiï sertsevo-sudynnoï systemy u khvorykh na khronichnyi hlomerulonefryt pislia vykorystannia v etapnii medychnii reabilitatsiï dozovanoï LFK.

As many as 195 patients were studied presenting with mixed, nephrotic, and hematuric varieties of chronic glomerulonephritis (ChG), aged 6-15 years, including 118 children from the test-groups who were given a combined therapy involving differentiated rest-and-movement regimens (DRMR) and graded therapeutical physical training (GTPT) and 77 controls who received none of the above treatments. The examination involved clinical as well as functional tests (the unit "Cardiocid"-aided ECG, EchoCG on the "Combison-420-5"), with the renal function being evaluated as recommended by Ota Shiuk. Commonly seen in those being admitted into hospital was nephrogenous hypertension as were abnormal changes in myocardium associated with automatism malfunction, inadequate conductivity, and impaired myocardial contractile ability. Clinical and functional tests as a whole suggested to us a latent cardiac insufficiency in those children presenting with faulty kidney function. Use of DRMR and GTPT in a complex of therapeutic and rehabilitative measures in a continuous staged medical rehabilitation project makes for improvement of the function of the cardiovascular system in all of the varieties of the condition particularly so in hematuric and nephrotic forms of ChG, as evidenced by ECG and EchoCG in a 5-yr follow-up.

[The treatment procedure and medical rehabilitation of children with the nephrotic form of glomerulonephritis]. / Taktika lecheniia i meditsinskaia reabilitatsiia detei s nefroticheskoi formoi glomerulonefrita.

The article deals with the analysis of the results of radionuclide studies in 624 children with the nephrotic form of glomerulonephritis according to the effect of pathogenetic therapy in the immediate and late-term periods. The authors determined the values characterizing the renal hemodynamics and the functional and metabolic condition of the kidneys and allowing the probable outcome of the disease to be appraised. The severity of the functional disorders in the period of marked clinical manifestations of glomerulo-nephritis and the changes of the values during treatment allows the tactics of the therapeutic measures to be determined. The persistence of renal hemodynamic disorders in the follow-up of patients with a complete clinico-laboratory remission is shown, which dictates the necessity for increasing the time of medical rehabilitation in the nephrotic form of glomerulonephritis in children.