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J Vet Med Sci ; 72(11): 1495-9, 2010 Nov.
Article in English | MEDLINE | ID: mdl-20585192

ABSTRACT

The cerebellar lesions of three dogs with canine neuroaxonal dystrophy (NAD), one dog with cerebellar cortical abiotrophy (CCA), and 4 dogs with neuronal ceroid-lipofuscinosis (NCL) were examined to understand their pathogeneses. Purkinje cell loss was most severe in the vermis of a dog with CCA, and granule cell loss was most prominent in the cerebellar hemisphere of dogs with NCL. Immunohistochemically, CD3-and HLA-DR-positive cells were most frequent in the dogs with NCL, and moderate in dogs with NAD, but not in a dog with CCA. The number of cleaved caspase 3-positive cells was prominent in a dog with CCA, but no significant in the dogs with NAD. The results indicate different pathway of neuronal loss of these canine neuronal disorders.


Subject(s)
Dog Diseases/pathology , Neuroaxonal Dystrophies/veterinary , Neuronal Ceroid-Lipofuscinoses/veterinary , Spinocerebellar Degenerations/veterinary , Animals , Caspase 3/metabolism , Cerebellar Cortex/enzymology , Cerebellar Cortex/pathology , Cerebellum/pathology , Dogs , Female , Male , Neuroaxonal Dystrophies/enzymology , Neuroaxonal Dystrophies/mortality , Neuroaxonal Dystrophies/pathology , Neuronal Ceroid-Lipofuscinoses/mortality , Neuronal Ceroid-Lipofuscinoses/pathology , Orchiectomy/veterinary , Purkinje Cells/pathology , Spinocerebellar Degenerations/pathology
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