ABSTRACT
A human neurofibrosarcoma was removed at surgery from a patient with neurofibromatosis and implanted into the subrenal capsule of female nude mice (nu/nu). A solid tumor grew and was transferred to 78 additional mice for this study. The animals were randomly assigned to one of four groups: 1) control, 27 animals; 2) oral heparin (200 or 500 U/ml), 17 animals; 3) oral hydrocortisone (0.3 mg/ml), 10 animals; or 4) oral heparin (200, 500, or 1000 U/ml) with hydrocortisone (0.3 mg/ml), 24 animals. After 10 days of treatment, the animals were sacrificed and the tumor size and degree of neovascularization were compared to the pretreatment data. Heparin treatment alone stimulated angiogenesis and resulted in tumor growth greater than in the control group (p less than 0.001). Administration of hydrocortisone alone caused a minimal reduction in tumor growth and had a minimal effect on angiogenesis (p less than 0.05 vs. control group). In contrast, heparin administered with hydrocortisone inhibited both angiogenesis and tumor growth (p less than 0.001 vs. control group). These studies suggest that angiogenesis modulators are worthy of further study as feasible means of treating human neurofibrosarcoma.
Subject(s)
Heparin/therapeutic use , Hydrocortisone/therapeutic use , Neurofibromatosis 1/blood supply , Animals , DNA, Neoplasm/analysis , Disease Models, Animal , Drug Therapy, Combination , Female , Humans , Mice , Mice, Nude , Neoplasm Transplantation , Neovascularization, Pathologic/pathology , Neurofibromatosis 1/drug therapy , Neurofibromatosis 1/pathologySubject(s)
Aneurysm/etiology , Chiropractic , Head and Neck Neoplasms/blood supply , Manipulation, Orthopedic/adverse effects , Neck/blood supply , Neurofibromatosis 1/blood supply , Arteries/injuries , Head and Neck Neoplasms/diagnostic imaging , Humans , Male , Middle Aged , Neurofibromatosis 1/diagnostic imaging , RadiographyABSTRACT
This presentation demonstrates the fluorescein angiographic characteristics of the cilio-optic vein. These congenitally enlarged vessels appear at the disc edge and dip into the optic nerve to anastomose with branches of the central retinal vein. Fluorescein angiography shows lamellar filling of the vessels in the early choroidal phase. In one patient, these findings are demonstrated bilaterally with the use of bilateral simultaneous angiography. A second type of communication is presented, a retinociliary vein which drains the retina into the choroidal circulation. In both types presented, a branching hypofluorescent pattern extends from the disc vessel into the choroid. Our patients have evidence of a phakomatosis: neurofibromatosis or Sturge-Weber syndrome. This anomalous disc vessel should not be confused with optociliary shunt, disc neovascularization, cilioretinal artery, or arteriovenous shunt.
