1.
Farmaco Sci
; 33(2): 118-25, 1978 Feb.
Article
in English
| MEDLINE
| ID: mdl-204511
ABSTRACT
The alpha-adrenolytic activity of 1-methyl-10-methoxydihydrolysergol 2-(3,5-dimethyl)pyrrolcarboxylate (XV, formula II) is, both in vitro and parenterally, quite similar to that of dihydroergotamine. By oral route the new compound is more active, and longer lasting than dihydroergotamine.
Subject(s)
Ergolines/chemical synthesis , Nicergoline/chemical synthesis , Sympatholytics/chemical synthesis , Administration, Oral , Animals , Delayed-Action Preparations , Dihydroergotamine/pharmacology , Guinea Pigs , Injections, Intravenous , Male , Nicergoline/administration & dosage , Nicergoline/analogs & derivatives , Receptors, Adrenergic, alpha/drug effects , Structure-Activity Relationship
2.
Farmaco Sci
; 30(10): 789-801, 1975 Oct.
Article
in English
| MEDLINE
| ID: mdl-241664
ABSTRACT
The synthesis and the pharmacological activities of 24 analogues of the alpha-adrenergic blocking drug, nicergoline (I b), are reported. The majority of the new compounds were found to be less active than (I b): the structure-activity relationships are presented and discussed.
