[Study of plasma and hepatic hydrolysis of nitroxinil derivatives]. / Etude de l'hydrolyse plasmatique et hépatique de dérivés du Nitroxinil.

Seven esters derivatives of Nitroxinil were prepared and their structures were assigned by IR and 1H-NMR spectroscopy. The rate of plasma and hepatic hydrolysis were evaluated in vitro in sheep and rabbit. In view of this profile of activity, pivaloyl derivative merits evaluation, in vivo.

[Distribution and retention of nitroxinil in the tissues and fluids of large and small ruminants treated with fasciolide]. / Prouchvaniia vurkhu razpredelenieto i zadurzhaneto na nitroksinil v tukani i technosti na edri i drebni prezhivni zhivotni, tretirani s fastsiolid.

Nitroxynil distribution and the period of its retention in the organism of sheep and calves subcutaneously treated with therapeutical doses of the Bulgarian patent medicine fasciolid which contains N-methylglucaminic-nitro-xynil salt were followed. Comparative studies were carried out using the patent medicine dovenix "Specia". The polarographic method, based on nitro-group reduction over a dripping mercury electrod was applied for nitroxynil determination. It was established that fasciolid and dovenix applied to sheep and cattle in a prophylactic-therapeutic dose did not differ significantly in their distribution and retention in the organism.