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Ann Pharm Fr ; 54(5): 223-7, 1996.
Article in French | MEDLINE | ID: mdl-8953797

ABSTRACT

Seven esters derivatives of Nitroxinil were prepared and their structures were assigned by IR and 1H-NMR spectroscopy. The rate of plasma and hepatic hydrolysis were evaluated in vitro in sheep and rabbit. In view of this profile of activity, pivaloyl derivative merits evaluation, in vivo.


Subject(s)
Liver/metabolism , Nitroxinil/analogs & derivatives , Nitroxinil/blood , Prodrugs , Animals , Hydrolysis , In Vitro Techniques , Nitroxinil/metabolism , Rabbits , Sheep
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