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2.
Biogr Mem Fellows R Soc ; 52: 1-13, 2006.
Article in English | MEDLINE | ID: mdl-18543469

ABSTRACT

Julie Axelrod was a laboratory technician until the age of 42, when he finally achieved his PhD and independence. He worked at the National Institutes of Health for most of his career. Among his early pioneering research achievements in applying chemical and biochemical approaches to neuroscience were the discoveries of the painkiller acetaminophen (Tylenol, Paracetamol) and the liver microsomal drug-metabolizing enzymes, and the establishment of catechol-O-methyltransferase as an important enzyme in catecholamine metabolism. He shared the Nobel Prize in Physiology or Medicine in 1970 for his discovery that the reuptake of noradrenaline (norepinephrine) into the nerve endings from which it was released represented a novel method of neurotransmitter inactivation. An important corollary was the finding that antidepressant drugs acted as inhibitors of this uptake process. Subsequent work in his laboratory on the control of melatonin biosynthesis in the pineal gland provided new insights into the way in which the nervous system controls circadian rhythms, and offered an early model system in which to study the rapid control of mammalian gene expression. Axelrod continued actively in research until shortly before his death, and trained many students who have gone on to become leaders of the new field of biochemical neuropharmacology.


Subject(s)
Acetaminophen/history , National Institutes of Health (U.S.) , Nobel Prize , Norepinephrine , Acetaminophen/pharmacokinetics , History, 20th Century , History, 21st Century , Melatonin/history , Melatonin/pharmacokinetics , National Institutes of Health (U.S.)/history , Norepinephrine/history , Norepinephrine/metabolism , Norepinephrine/pharmacokinetics , Norepinephrine/physiology , Pineal Gland/physiology , Research/history , United States
3.
Sleep ; 25(1): 68-87, 2002 Feb 01.
Article in English | MEDLINE | ID: mdl-11833857

ABSTRACT

The results of a series of studies on total and selective sleep deprivation in the rat are integrated and discussed. These studies showed that total sleep deprivation, paradoxical sleep deprivation, and disruption and/or deprivation of non-rapid eye movement (NREM) sleep produced a reliable syndrome that included death, debilitated appearance, skin lesions, increased food intake, weight loss, increased energy expenditure, decreased body temperature during the late stages of deprivation, increased plasma norepinephrine, and decreased plasma thyroxine. The significance of this syndrome for the function of sleep is not entirely clear, but several changes suggested that sleep may be necessary for effective thermoregulation.


Subject(s)
Brain/physiopathology , Sleep Deprivation/history , Animals , Body Temperature Regulation/physiology , Circadian Rhythm/physiology , Electroencephalography/history , Energy Metabolism/physiology , Grooming , History, 20th Century , Norepinephrine/blood , Norepinephrine/history , Rats , Skin Diseases/etiology , Skin Diseases/history , Sleep Deprivation/physiopathology , Sleep Stages/physiology , Stress, Physiological/history , Stress, Physiological/psychology , Thyroxine/blood
6.
Pharmacopsychiatry ; 28 Suppl 1: 24-37, 1995 Sep.
Article in English | MEDLINE | ID: mdl-7480108

ABSTRACT

After intraventricular injection of norepinephrine-H3, the concentration of norepinephrine, of normetanephrine and of the deaminated catechols in rat brains was determined, following action of imipramine, desmethylimipramine, chlorpromazine, lithium chloride or cocaine. Following administration of imipramine, desmethylimipramine, and chlorpromazine, norepinephrine concentration decreased significantly at first, had distinctly increased 4.5 hours after imipramine and desmethylimipramine but was normal once again after chlorpromazine. Normetanephrine concentration increased after imipramine and desmethylimipramine but was unchanged after chlorpromazine. Under the effect of these drugs, the deaminated catechols showed no changes compared with control values. Cocaine resembled the antidepressants, but the amount of deaminated compounds was reduced. Lithium chloride, on the other hand, increased the concentration of deaminated catechols under certain conditions, reduced normetanephrine concentration but did not influence norepinephrine concentration. In addition to the animal experiments, the following data of six patients with an "endogenous" depression were recorded over a period of several weeks: the clinical findings by means of the Hamilton Depression Rating Scale, and the excretion of normetanephrine and of vanillylmandelic acid (VMA) in the urine before, during and after treatment with imipramine. The therapy led to a significant reduction of VMA; however, this reduction cannot be correlated with an improvement in the clinical findings. On the other hand, excretion of normetanephrine is apparently not dependent on the administration of imipramine but seems to reflect the clinical state, since improvement of the depression was regularly combined with an increased excretion of normetanephrine.


Subject(s)
Depressive Disorder/history , Norepinephrine/history , Psychotropic Drugs/history , Animals , Depressive Disorder/drug therapy , Depressive Disorder/metabolism , History, 20th Century , Humans , Norepinephrine/metabolism , Psychotropic Drugs/pharmacology , Psychotropic Drugs/therapeutic use , Rats
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