ABSTRACT
AIM: Extranodal natural killer cell/T-cell lymphoma of nasal-type (NKTCL) is an aggressive human lymphoma, but its predicted biomarkers after chemotherapy are less known. The aim of this study is to find some potential predicted biomarkers in cerebrospinal fluid (CSF) of NKTCL patients with ethmoidal sinus metastasis (NESM). MATERIALS AND METHODS: The CSF samples were obtained from NKTCL patients with NESM before and after chemotherapy from Cancer Center of West China Hospital. Comparative proteomic profiling using label-free method was performed to characterize the fold change of proteins in NESM patients. KEY FINDING: In this study, 102 proteins with <1% false discovery rate in CSF of NKTCL with NESM patients were quantified. Furthermore, significantly reduced IGFBP2, SERP1NC1, AMBP and GPX3, as well as dramatically increased CPE levels were observed in the CSF of NKTCL patients after cytarabine chemotherapy. SIGNIFICANCE: IGFBP2, SERP1NC1, AMBP, GPX3 and CPE together or alone have a potential to be predicted indicators of NKTCL with NESM in response to chemotherapy.
Subject(s)
Biomarkers, Tumor/cerebrospinal fluid , Cerebrospinal Fluid/metabolism , Ethmoid Sinus/pathology , Lymphoma, Extranodal NK-T-Cell/cerebrospinal fluid , Nose Neoplasms/cerebrospinal fluid , Proteomics/methods , Adult , Antineoplastic Agents/therapeutic use , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , China , Cytarabine/therapeutic use , Female , Gene Expression Profiling , Gene Expression Regulation, Neoplastic , Humans , Lymphoma, Extranodal NK-T-Cell/pathology , Male , Mass Spectrometry , Middle Aged , Neoplasm Metastasis , Nose Neoplasms/pathology , Prognosis , Tandem Mass SpectrometryABSTRACT
BACKGROUND: Lymphomas that infiltrate the nervous system in children correspond to those of precursor B cells, such as lymphoblastic and Burkitt's lymphoma. In adults, infiltration occurs in mature B-cell lymphomas, such as mantle cell lymphoma, and, rarely, in Hodgkin's lymphoma or peripheral NK/T-cell lymphomas. CASE: We report the case of a 48-year-old man, who two years before death was diagnosed with extranodal nasal NK/T-cell lymphoma nasal in the left nostril. He received radiotherapy and a year later presented tumor activity. He also presented infiltration to the bone marrow and underwent chemotherapy. Afterward, he presented paresthesia and paresis of the lower extremities, difficulty walking, loss of sphincter control, and seizures. Infiltration to the central nervous system was revealed by computed axial tomography, and cytologic study of cerebrospinal fluid revealed malignant lymphoid cells; he then received intrathecal chemotherapy. He died 3 months later. CONCLUSION: In Mexico, extranodal nasal NK/T-cell lymphoma occurs frequently. It is highly destructive and tightly related with the Epstein-Barr virus. Infiltration to the central nervous system is rare, and the neoplastic cells can be confused with other tumors, such as metastatic carcinomas.
