Obesity Indices and Ventilatory Function Responses to High-Level Laser Therapy in Subjects with Abdominal Obesity.

Objective: The aim of this study is to investigate the effectiveness of pulsed Nd:YAG high-intensity laser therapy (HILT) on body weight (Wt), body-mass index (BMI), waist circumference (WC), forced vital capacity (FVC), and forced expiratory volume in 1 sec (FEV1) in young adults with abdominal obesity (AO). Materials and methods: Thirty-seven young adult males (age 19-25 years) with BMI >30 kg/m2 and WC >102 cm participated in this 12-week, randomized controlled study and were randomly allocated into either Group I [received pulsed Nd:YAG HILT plus moderate-intensity aerobic exercise training (AET) program] or Group II (received placebo pulsed Nd:YAG HILT plus the same AET program). The variables were evaluated pre- and poststudy. Results: Poststudy mean values and percentages of changes were calculated for Wt [83.7 ± 6.58 kg (-6.14%) and 88.71 ± 5.09 kg (-4.29%)], BMI [29.27 ± 1.06 kg/m2 (-6.14%) and 30.09 ± 1.23 kg/m2 (-4.24%)], WC [105.44 ± 5.84 cm (-3.78%) and 109.42 ± 4.9 cm (-1.74%)], FVC [4.79 ± 0.4 L (+13.6%) and 4.39 ± 0.66 L (+5.89%)], and FEV1 [4.04 ± 0.22 L (+16.4%) and 3.82 ± 0.39 L (+8.8%)] for Group I and Group II, respectively. Between groups, there were significant differences in mean values of Wt (p = 0.014), BMI (p = 0.04), WC (p = 0.03), FVC (p = 0.03), and FEV1 (p = 0.04) at the end of the study, but in favor of Group I. Conclusions: Utilizing the pulsed Nd:YAG HILT as an adjunctive therapeutic modality proved to be effective in improving the anthropometric indices and ventilatory functions in subjects with AO.

Visceral Adipose Tissue Modulates Radiosensitivity in Oesophageal Adenocarcinoma.

Oesophageal adenocarcinoma (OAC) is an exemplar model of obesity-associated cancer. Response to neoadjuvant chemoradiotherapy (NA CRT) is a clinical challenge. We examined if visceral adipose tissue and obesity status alter radiosensitivity in OAC. The radioresistant (OE33R) and radioresponsive (OE33P) OAC isogenic model was cultured with adipose tissue conditioned media from three patient cohorts: non-cancer patients, surgery only OAC patients and NA CRT OAC patients. Cell survival was characterised by clonogenic assay, metabolomic profiling by nuclear magnetic resonance spectroscopy and adipokine receptor gene expression by qPCR. A retrospective in vivo study compared tumour response to NA CRT in normal weight (n=53) versus overweight/obese patients (n=148). Adipose conditioned media (ACM) from all patient cohorts significantly increased radiosensitivity in radioresistant OE33R cells. ACM from the NA CRT OAC cohort increased radiosensitivity in OE33P cells. Metabolomic profiling demonstrated separation of the non-cancer and surgery only OAC cohorts and between the non-cancer and NA CRT OAC cohorts. Gene expression profiling of OE33P versus OE33R cells demonstrated differential expression of the adiponectin receptor-1 (AR1), adiponectin receptor-2 (AR2), leptin receptor (LepR) and neuropilin receptor-1 (NRP1) genes. In vivo overweight/obese OAC patients achieved an enhanced tumour response following NA CRT compared to normal weight patients. This study demonstrates that visceral adipose tissue modulates the cellular response to radiation in OAC.

Quantification of adipose volume reduction with a prospective study analyzing the application of external radiofrequency energy and high voltage ultrashort pulse duration electrical fields.

To date, there have been no objective measurements of subcutaneous volume loss following treatments with a noninvasive radiofrequency (RF)-based device. Twenty female patients were treated with a suction-coupled bipolar RF device using external RF energy combined with pulsed electromagnetic RF energy for subcutaneous fat reduction. Parameters followed included weight, Vectra measurements of abdominal circumference and torso volume, and high-definition ultrasound measurements of fat thickness. Measurements were taken before treatment and three times following treatment. Analysis of the measured parameters showed that mean circumference reduction of 2.30 cm was noted at three months post-treatment. Independent volumetric analysis showed a mean subcutaneous volume reduction of 428 cc three months following RF treatment. High-resolution ultrasound fat thickness was reduced by a mean of 39.6% three months following the final BodyFX treatment. Independent and paired-sample t-tests showed a p value of < 0.05. Repeated measures of analysis of covariance (ANCOVA) adjusted for differences in age, as well as height and weight (proxy for body mass index) to minimize individual differences and control for extraneous variables that may affect the pre- and post-treatment results were analyzed. No confounding variables were found. All analyses were conducted using IBM SPSS 21.0.

Cryolipolysis versus laser lipolysis on adolescent abdominal adiposity.

BACKGROUND: Noninvasive body contouring is one of the fastest growing segments of the cosmetic aesthetic industry. There is increased public demand for procedures with fewer side effects and shorter recovery times. Cryolipolysis and Laser lipolysis have been used as treatments for localized body contouring. OBJECTIVE: To compare the effect of Cryolipolysis versus Laser lipolysis on adolescent's abdominal adiposity. DESIGN: Randomized, controlled trial. SUBJECTS: Forty-five obese adolescents of both sexes ranged in age from 13 to 16 years participated in this study were to be categorized into three groups of equal number (each group 15 subjects) randomly selected from population. METHODS: Participants were randomly assigned to three groups. Group A was received (Cryolipolysis and diet), Group B was received (Laser lipolysis and diet), Group C was received (only diet) all groups were observed for 8 weeks. Weight and height scale for (change in weight), tape measurement for (waist-hip ratio), skinfold caliper, and MRI. RESULTS: There was no significant difference between three groups post-treatment in BMI and body weight P-value were (0.2, 0.42, 0.67), respectively. There was a significant improvement for Cryolipolysis group in waist-hip ratio, Suprailiac skin fold, and subcutaneous adipose tissue than other groups P-value (0.001). CONCLUSIONS: Cryolipolysis has a favorable effect than Laser lipolysis in the reduction of waist-hip ratio, skin folds at Suprailiac level and subcutaneous adipose tissue (SAT), there is no significant difference between them in the reduction of BMI and body weight. All groups did not have an effect on VAT.